Dr. Sanchaita Rajkhowa

Assistant Professor, Centre for Biotechnology and Bioinformatics
  • Centre for Biotechnology and Bioinformatics
  • Designation - Assistant Professor

Profile

About Me:

I am a computational researcher  with specialization in Molecular Modeling and Computational Biology. My area of research focuses mainly on Computer aided Drug Design. My research field includes: 

  • Computer-aided drug design,
  • Density functional Theory,
  • Molecular Modeling,
  • Hybrid Quantum Mechanics/Molecular Mechanics,
  • Molecular dynamics
  • Computational Systems Biology

Contact info

Sanchaita's Profile: linkedin.com/in/sanchaita-rajkhowa-b7b67a24 

Important links

Google Scholar: https://scholar.google.com/citations?user=OQsXSNQAAAAJ

ResearchGate: https://www.researchgate.net/profile/Sanchaita-Rajkhowa

ORCID: https://orcid.org/0000-0002-4834-2654

Education:

  1. Ph.D. under Prof. Ramesh C. Deka, Department of Chemical Sciences (Tezpur University)
  2. Master’s Degree : M.Sc. in Bioinformatics (Dibrugarh University)
  3. Bachelor’s Degree : B.Sc. in Zoology (D.H.S.K. College, Dibrugarh)

Awards and Achievements:

    Awarded DST sponsored INSPIRE Fellowship for securing 1st Rank at Post Graduation level, 2011-2016.

Research Experiences:

  1. Worked as an independent postdoctoral fellow in the lab of Dr. Anupam Nath Jha, Department of Molecular Biology and Biotechnology, Tezpur University from Oct 2018 to Apr 2019.
  2. Worked as DBT Studentship in BIF, Department of Biotechnology, CSIR-North East Institute of Science and Technology (NEIST), Jorhat from October 2010-January 2011.
  3. Worked as an intern in CSIR-North East Institute of Science and Technology (NEIST), Jorhat, under the project named “Computer aided drug for targeting Catalase-Peroxidase of Mycobacterium tuberculosis”, from January 2010 - June 2010.

Invited Lecture/Speaker/Resource Person/Talk:

  • Invited as a Resource Person in the National Workshop on "QSAR/QSPR: Applications in Drug Designing" held from 14th to 16th February, 2015 at Department of Molecular Biology and Biotechnology, Tezpur University

 

Publications

Research Publications:

2017

  1. Rajkhowa S, Borah SM, Jha AN, Deka RC.  Design of Plasmodium falciparum PI(4)KIIIβ Inhibitor using Molecular Dynamics and Molecular Docking Methods. ChemistrySelect, 2017; 2(5): 1783-1792. (Impact factor = 1.811)

2016

  1. Saikia N, Rajkhowa S, Deka RC.  Si-Doped single-walled carbon nanotubes interacting with isoniazid-a density functional and molecular docking study. RSC Advances, 2016; 6(97): 94651-94660. (Impact factor = 3.07)
  2. Borah PK, Chakraborty  S, Jha AN, Rajkhowa  S, Duary RK.  In silico approaches and proportional odds model towards identifying selective adam17 inhibitors from anti-inflammatory natural molecules.  Journal of Molecular Graphics and Modelling, 2016; 70: 129-139. (Impact factor = 2.079)

2015

  1. Rajkhowa S, Jha AN, Deka RC.  Anti-tubercular drug development: computational strategies to identify potential compounds.  Journal of Molecular Graphics and Modelling, 2015; 62: 56-68. (Impact factor = 2.079)

2014

  1. Rajkhowa S, Deka RC. DFT based QSAR/QSPR models in the development of novel anti-tuberculosis drugs targeting Mycobacterium tuberculosis. Current Pharmaceutical Design, 2014; 20(27): 4455-73. (Impact factor = 2.412)

2013

  1. Rajkhowa S, Hussain I, Hazarika KK, Deka RC. Quantitative Structure-Activity Relationships of the Antimalarial Agent Artemisinin and some of its Derivatives - A DFT Approach. Combinatorial Chemistry & High Throughput Screening, 2013; 16(8): 590-602. (Impact factor = 1.205)
  2. Saikia N, Rajkhowa S, Deka RC. Density functional and molecular docking studies towards investigating the role of single-wall carbon nanotubes as nanocarrier for loading and delivery of pyrazinamide antitubercular drug onto pncA protein. Journal of Computer Aided Molecular Design, 2013; 27(3): 257-76. (Impact factor = 2.683) 

Book Chapters:

2021

  1. Das A, Pathak U, Rajkhowa S, Jha AN. Plasmodium falciparum: Experimental and Theoretical Approaches in Last 20 Years, in Current Topics and Emerging Issues in Malaria Elimination, IntechOpen Publishers, 2021 (DOI: 10.5772/intechopen.96529).
  2. Rajkhowa S, Hazarika Z,  Jha AN. Systems biology and bioinformatics approaches in leishmaniasis, in Applications of Nanobiotechnology for Neglected Tropical Diseases, Elsevier Academic Press, 2021, 509-548. ISBN: 978-0-12-821100-7 (doi: https://doi.org/10.1016/B978-0-12-821100-7.00018-2).

2020

  1. Hazarika Z, Rajkhowa S, Jha AN. Role of Force Fields in Protein Function Prediction, in Homology Molecular Modeling-Perspectives and Applications, IntechOpen Publishers, 2020, 31-51. Print ISBN: 978-1-83962-805-4, eBook (PDF) ISBN: 978-1-83962-811-5 (DOI: 10.5772/intechopen.93901).

2019

  1. Rajkhowa S, Jha AN. Molecular Dynamics Simulations - a Tool to Investigate the Interactions between Biomolecules and Nanoparticles, in An Introduction to Molecular Dynamics,  Nova Science Pub Inc, 2019, 65-108. ISBN-13: 978-1536160543.

2017

  1. Rajkhowa S, Deka RC. Protein-Ligand Docking Methodologies and Its Application in Drug Discovery, in Methods and Algorithms for Molecular Docking-based Drug Design and Discovery, IGI Globals, 2017, 196-219. ISBN13: 9781522501152 (DOI: 10.4018/978-1-5225-0115-2).

Conference Poster/Abstract/Oral Presentation
Oral:

  1. Oral presentation titled “Structure-based Drug Discovery using Plasmodium falciparum PI(4)KIIIβ as target” in the National conference on “Contemporary Developments in Chemical Sciences-2015” at Department of Chemical Sciences, Tezpur university, from 23rd - 24th November, 2015.
  2. Oral presentation titled “In-silico Screening of Anti-tubercular Drug Triclosan and its Derivatives Targeting InhA Protein” in the National seminar on “Recent Advances in Biotechnology research in North East India: Challenges and Prospects” at Department of Molecular Biology and Biotechnology, Tezpur University from 27th- 29th November, 2014.


Poster:

  1. Poster Presentation entitled “Interaction mechanism of Withanone and Withaferin-A from Withania somnifera with Lysozyme, Serum Albumin and Haemoglobin – A Molecular Dynamics Approach” presented at “The 19th International Conference on Bioinformatics (InCoB)” organized by APBioNET, from Nov 25-29, 2020.
  2. Poster presentation titled “Toward Plasmodium falciparum PI(4)KIIIβ Inhibitor Design” at the SERB-DST sponsored National Seminar on Emerging Global Trends in Pharmaceutical Nanotechnology, from November 23-24, 2018, organized by Department of Pharmaceutical Sciences, Dibrugarh University.
  3. Poster presentation titled “Molecular docking, molecular dynamics simulation studies and Quantitative Structure-Activity Relationships of the Anti-tubercular compound Triclosan and some of its derivatives – A Density Functional Theory Approach”, at 8th Mid-Year CRSI National Symposium in Chemistry held at CSIR-North East Institute of Science and Technology, Jorhat and Tezpur University from 10th – 12th July, 2014.
  4. Poster presentation titled “DFT, docking and molecular dynamics analysis of the crystal structure of mycobacterial InhA protein”, at International Symposium on Chemistry with Computers held at IIIT Hyderabad and IICT Hyderabad from January 18th – 19th, 2014.
  5. Poster presentation titled “Cross-docking study of a few InhA proteins with triclosan and some of its derivatives” at Theoretical Chemistry Symposium 2012 organized by Department of Chemistry, Indian Institute of Technology, Guwahati (IITG), from 19th – 22nd  December, 2012.
  6. Poster presentation titled “Quantitative Structure-Activity Relationships of the Antimalarial Agent Artemisinin and some of its Derivatives - A DFT Approach”, at the National seminar on “Current trends in Computational Chemistry” organized by Department of Chemistry, North Eastern Hill University, NEHU, from 16th -17th  March 2012.

Workshop and winter school:

  1. Attended workshop entitled "Massive Open Online Courses (MOOCs) organized by EMRC, Dibrugarh University on 28th and 29th January 2021.
  2. Attended workshop entitled “Visualisation and Analysis of Complex Networks in Biology - An introduction to Biological Networks, their types and applications” organized by organized by APBioNET, held on 27th November, 2020.
  3. Lecture workshop on Computational Chemistry organized by Department of Chemistry, Dibrugarh University, from 19th – 21st November 2018.
  4. DST – SERB Winter School on Modeling Chemical and Biological (Re) activity organised IIIT Hyderabad from January 2 – 22, 2014.
  5. Workshop on Data Deluge in Biology: Use of High-Performance Grid & Cloud Computing, organized during 19-20th Dec 2013 at Jorhat Medical College & Hospital campus.
  6. Workshop on ‘Basic Techniques in Bioinformatics’ 12th -14th October, 2011 organized by Bioinformatics facility, Department of Biotechnology, IIT, Guwahati.
  7. National workshop on ‘Recent Advances in In-Silico Drug Design and X-Ray Crystallography’ organized by Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong from July 25th - 30th, 2011.

Faculty Development Programmes Attended:

  1. Attended e-FDP Programme on Data Science organized by Intershala, from 5th June 2020 – 17th July 2020.
  2. Attended e-FDP Programme on Importance of Cross-disciplinary Research in the Post Covid-19 Scenerio: Social Perspectives organized by Royal Global University, Guwahati, from 16th June 2020 – 23rd June 2020.

Courses Taken

1. Bioinformatics and Biostatistics 

2. IPR, Biosafety and Bioethics

3. Research Methodology

4. Drug Discovery-I (Principles of Drug Design)

5. Drug Discovery-II (Computer Aided-Drug Design)

6. Drug Discovery – III (Advanced Computer Aided Drug Design)

 

 

 

 

Profile

Profile

About Me:

I am a computational researcher  with specialization in Molecular Modeling and Computational Biology. My area of research focuses mainly on Computer aided Drug Design. My research field includes: 

  • Computer-aided drug design,
  • Density functional Theory,
  • Molecular Modeling,
  • Hybrid Quantum Mechanics/Molecular Mechanics,
  • Molecular dynamics
  • Computational Systems Biology

Contact info

Sanchaita's Profile: linkedin.com/in/sanchaita-rajkhowa-b7b67a24 

Important links

Google Scholar: https://scholar.google.com/citations?user=OQsXSNQAAAAJ

ResearchGate: https://www.researchgate.net/profile/Sanchaita-Rajkhowa

ORCID: https://orcid.org/0000-0002-4834-2654

Education:

  1. Ph.D. under Prof. Ramesh C. Deka, Department of Chemical Sciences (Tezpur University)
  2. Master’s Degree : M.Sc. in Bioinformatics (Dibrugarh University)
  3. Bachelor’s Degree : B.Sc. in Zoology (D.H.S.K. College, Dibrugarh)

Awards and Achievements:

    Awarded DST sponsored INSPIRE Fellowship for securing 1st Rank at Post Graduation level, 2011-2016.

Research Experiences:

  1. Worked as an independent postdoctoral fellow in the lab of Dr. Anupam Nath Jha, Department of Molecular Biology and Biotechnology, Tezpur University from Oct 2018 to Apr 2019.
  2. Worked as DBT Studentship in BIF, Department of Biotechnology, CSIR-North East Institute of Science and Technology (NEIST), Jorhat from October 2010-January 2011.
  3. Worked as an intern in CSIR-North East Institute of Science and Technology (NEIST), Jorhat, under the project named “Computer aided drug for targeting Catalase-Peroxidase of Mycobacterium tuberculosis”, from January 2010 - June 2010.

Invited Lecture/Speaker/Resource Person/Talk:

  • Invited as a Resource Person in the National Workshop on "QSAR/QSPR: Applications in Drug Designing" held from 14th to 16th February, 2015 at Department of Molecular Biology and Biotechnology, Tezpur University

 

Publications

Publications

 

Research Publications:

2017

  1. Rajkhowa S, Borah SM, Jha AN, Deka RC.  Design of Plasmodium falciparum PI(4)KIIIβ Inhibitor using Molecular Dynamics and Molecular Docking Methods. ChemistrySelect, 2017; 2(5): 1783-1792. (Impact factor = 1.811)

2016

  1. Saikia N, Rajkhowa S, Deka RC.  Si-Doped single-walled carbon nanotubes interacting with isoniazid-a density functional and molecular docking study. RSC Advances, 2016; 6(97): 94651-94660. (Impact factor = 3.07)
  2. Borah PK, Chakraborty  S, Jha AN, Rajkhowa  S, Duary RK.  In silico approaches and proportional odds model towards identifying selective adam17 inhibitors from anti-inflammatory natural molecules.  Journal of Molecular Graphics and Modelling, 2016; 70: 129-139. (Impact factor = 2.079)

2015

  1. Rajkhowa S, Jha AN, Deka RC.  Anti-tubercular drug development: computational strategies to identify potential compounds.  Journal of Molecular Graphics and Modelling, 2015; 62: 56-68. (Impact factor = 2.079)

2014

  1. Rajkhowa S, Deka RC. DFT based QSAR/QSPR models in the development of novel anti-tuberculosis drugs targeting Mycobacterium tuberculosis. Current Pharmaceutical Design, 2014; 20(27): 4455-73. (Impact factor = 2.412)

2013

  1. Rajkhowa S, Hussain I, Hazarika KK, Deka RC. Quantitative Structure-Activity Relationships of the Antimalarial Agent Artemisinin and some of its Derivatives - A DFT Approach. Combinatorial Chemistry & High Throughput Screening, 2013; 16(8): 590-602. (Impact factor = 1.205)
  2. Saikia N, Rajkhowa S, Deka RC. Density functional and molecular docking studies towards investigating the role of single-wall carbon nanotubes as nanocarrier for loading and delivery of pyrazinamide antitubercular drug onto pncA protein. Journal of Computer Aided Molecular Design, 2013; 27(3): 257-76. (Impact factor = 2.683) 

Book Chapters:

2021

  1. Das A, Pathak U, Rajkhowa S, Jha AN. Plasmodium falciparum: Experimental and Theoretical Approaches in Last 20 Years, in Current Topics and Emerging Issues in Malaria Elimination, IntechOpen Publishers, 2021 (DOI: 10.5772/intechopen.96529).
  2. Rajkhowa S, Hazarika Z,  Jha AN. Systems biology and bioinformatics approaches in leishmaniasis, in Applications of Nanobiotechnology for Neglected Tropical Diseases, Elsevier Academic Press, 2021, 509-548. ISBN: 978-0-12-821100-7 (doi: https://doi.org/10.1016/B978-0-12-821100-7.00018-2).

2020

  1. Hazarika Z, Rajkhowa S, Jha AN. Role of Force Fields in Protein Function Prediction, in Homology Molecular Modeling-Perspectives and Applications, IntechOpen Publishers, 2020, 31-51. Print ISBN: 978-1-83962-805-4, eBook (PDF) ISBN: 978-1-83962-811-5 (DOI: 10.5772/intechopen.93901).

2019

  1. Rajkhowa S, Jha AN. Molecular Dynamics Simulations - a Tool to Investigate the Interactions between Biomolecules and Nanoparticles, in An Introduction to Molecular Dynamics,  Nova Science Pub Inc, 2019, 65-108. ISBN-13: 978-1536160543.

2017

  1. Rajkhowa S, Deka RC. Protein-Ligand Docking Methodologies and Its Application in Drug Discovery, in Methods and Algorithms for Molecular Docking-based Drug Design and Discovery, IGI Globals, 2017, 196-219. ISBN13: 9781522501152 (DOI: 10.4018/978-1-5225-0115-2).

Conference Poster/Abstract/Oral Presentation
Oral:

  1. Oral presentation titled “Structure-based Drug Discovery using Plasmodium falciparum PI(4)KIIIβ as target” in the National conference on “Contemporary Developments in Chemical Sciences-2015” at Department of Chemical Sciences, Tezpur university, from 23rd - 24th November, 2015.
  2. Oral presentation titled “In-silico Screening of Anti-tubercular Drug Triclosan and its Derivatives Targeting InhA Protein” in the National seminar on “Recent Advances in Biotechnology research in North East India: Challenges and Prospects” at Department of Molecular Biology and Biotechnology, Tezpur University from 27th- 29th November, 2014.


Poster:

  1. Poster Presentation entitled “Interaction mechanism of Withanone and Withaferin-A from Withania somnifera with Lysozyme, Serum Albumin and Haemoglobin – A Molecular Dynamics Approach” presented at “The 19th International Conference on Bioinformatics (InCoB)” organized by APBioNET, from Nov 25-29, 2020.
  2. Poster presentation titled “Toward Plasmodium falciparum PI(4)KIIIβ Inhibitor Design” at the SERB-DST sponsored National Seminar on Emerging Global Trends in Pharmaceutical Nanotechnology, from November 23-24, 2018, organized by Department of Pharmaceutical Sciences, Dibrugarh University.
  3. Poster presentation titled “Molecular docking, molecular dynamics simulation studies and Quantitative Structure-Activity Relationships of the Anti-tubercular compound Triclosan and some of its derivatives – A Density Functional Theory Approach”, at 8th Mid-Year CRSI National Symposium in Chemistry held at CSIR-North East Institute of Science and Technology, Jorhat and Tezpur University from 10th – 12th July, 2014.
  4. Poster presentation titled “DFT, docking and molecular dynamics analysis of the crystal structure of mycobacterial InhA protein”, at International Symposium on Chemistry with Computers held at IIIT Hyderabad and IICT Hyderabad from January 18th – 19th, 2014.
  5. Poster presentation titled “Cross-docking study of a few InhA proteins with triclosan and some of its derivatives” at Theoretical Chemistry Symposium 2012 organized by Department of Chemistry, Indian Institute of Technology, Guwahati (IITG), from 19th – 22nd  December, 2012.
  6. Poster presentation titled “Quantitative Structure-Activity Relationships of the Antimalarial Agent Artemisinin and some of its Derivatives - A DFT Approach”, at the National seminar on “Current trends in Computational Chemistry” organized by Department of Chemistry, North Eastern Hill University, NEHU, from 16th -17th  March 2012.

Workshop and winter school:

  1. Attended workshop entitled "Massive Open Online Courses (MOOCs) organized by EMRC, Dibrugarh University on 28th and 29th January 2021.
  2. Attended workshop entitled “Visualisation and Analysis of Complex Networks in Biology - An introduction to Biological Networks, their types and applications” organized by organized by APBioNET, held on 27th November, 2020.
  3. Lecture workshop on Computational Chemistry organized by Department of Chemistry, Dibrugarh University, from 19th – 21st November 2018.
  4. DST – SERB Winter School on Modeling Chemical and Biological (Re) activity organised IIIT Hyderabad from January 2 – 22, 2014.
  5. Workshop on Data Deluge in Biology: Use of High-Performance Grid & Cloud Computing, organized during 19-20th Dec 2013 at Jorhat Medical College & Hospital campus.
  6. Workshop on ‘Basic Techniques in Bioinformatics’ 12th -14th October, 2011 organized by Bioinformatics facility, Department of Biotechnology, IIT, Guwahati.
  7. National workshop on ‘Recent Advances in In-Silico Drug Design and X-Ray Crystallography’ organized by Department of Biotechnology and Bioinformatics, North Eastern Hill University, Shillong from July 25th - 30th, 2011.

Faculty Development Programmes Attended:

  1. Attended e-FDP Programme on Data Science organized by Intershala, from 5th June 2020 – 17th July 2020.
  2. Attended e-FDP Programme on Importance of Cross-disciplinary Research in the Post Covid-19 Scenerio: Social Perspectives organized by Royal Global University, Guwahati, from 16th June 2020 – 23rd June 2020.
Courses Taken
Current Courses
Sponsored Projects