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Dr. Hans Raj Bhat

Assistant Professor, Department of Pharmaceutical Sciences
  • Email - hansrajbhat@dibru.ac.in
  • Phone No. - 0373-2370254
  • Department of Pharmaceutical Sciences
  • Designation - Assistant Professor

Profile

Education:

  1. Bachelor’s Degree: B. Pharm Mohanlal Sukhadia University, Udaipur, Rajasthan 2005
  2. Master’s Degree: M.Pharm Dibrugarh University, Assam, 2008
  3. Ph.D.: Pharmaceutical Sciences Dibrugarh University, Assam, 2014
  4. Other:
    1. GATE 2006 IIT Kharagpur
    2. GATE 2007 IIT Kanpur

Professional Experience: 14.7 Years

 

Areas of Interest/ Specialization:

  • Medicinal Chemistry, Antimalarial Drug Development, Antibacterial Activity, Anti Cancer activity

 

Project undertaken: 

Founding Agency

Project Title

Grant No.

PI/Co-PI
DST

Design, Microwave Assisted Syntheisis and Antmalanal Evaluation of Hybrid Para-Amino- Benzoic Acid-I,3,5-triazine derivatives

EMR/2017/000708

Co-PI
DU

Design, synthesis and anti-Alzheimer activity evaluation of tri-substituted 1,3,5 -triazine derivatives

DU/3183-84

PI
AICTE Design, synthesis and antimalarial evaluation of hybrid pyrazoline substituted 1,3,5-triazine derivatives

8-21/FDC/RPS

(NER)/POLICY-1

/2020-21		 PI

 

Ph.D Scholars:

S.No.

Name

Topic

Status

1.

Ms. Ashmita Saha

Design, microwave assisted synthesis and antimalarial evaluation of hybrid para-amino benzoic acid-1,3,5-triazine derivatives.

On going

 

2.

Ms. Ayesha Aktar

Novel 2,4,6-trisubstituted 1,3,5-triazine derivatives conjugated with para-glutamic acid as potent antifolate for malaria pf-DHFR inhibition.

 Thesis Submitted

3.

Ms. Pooja Patowary

Design, Synthesis and Anti- Alzheimer's Evaluation of Coumarin Derivatives

On going

(24/09/2020)

4.

Ms. Tutumoni Kalita  

Design, synthesis and anti-alzheimer evaluation of novel triazine derivatives

On going (07/03/2022)
5 Mr. Farak Ali Evaluation of Anti-Alzheimer activity in substituted Hydroxymethyl phthalimide 1,3,5-triazine derivatives On going (10/04/2023)

                                                     

                                                                                          

 

Publications

Research Publications:

Article Published:

  • Saha A, Choudhury AAK, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, Singh UP, Bhat HR (2023) In silico screening, synthesis, and antimalarial evaluation of PABA substituted 1,3,5-triazine derivatives as Pf-DHFR inhibitors. Exp Parasitol. 250:108546. (IF-2.13)doi: 10.1016/j.exppara.2023.108546.
  • Gupta A, Bhat HR, Singh UP (2023) Discovery of novel hybrids of Morpholino-1,3,5-triazine-pyrimidine as an anti-diabetic agent in High-fat, Low-dose Streptozotocin-induced diabetes in Wistar rats: An in-vitro, in-silico and in-vivo study. J. Mol. Struct. (IF-3.80) ISSN (online): 0022-2860. DOI: https://doi.org/10.1016/j.molstruc.2023.136478
  • Gupta A, Bhat HR, Singh UP (2023) Discovery of novel 1,3,5-triazine derivatives as an anti-diabetic agent in Wistar rats via inhibition of DPP-4. Future Med Chem. 15(10):829-852  (IF-4.76) ISSN (print): 1756-8919. DOI: 10.4155/fmc-2022-0312
  • Gupta A, Bhat HR, Singh UP (2023) Discovery of Imeglimin-inspired novel 1,3,5-triazine derivatives as an antidiabetic agent in Streptozotocin-induced Diabetes in Wistar rats via inhibition of DPP-4. RSC Med. Chem., 14, 1512-1536 DOI: https://doi.org/10.1039/D3MD00085K  (IF-3.47) ISSN (print): 2632-8682
  • Kumari S, Ali S, Rahman O, Kumar A, Bhat HR, Ghosh SK, Shakya A (2023) Ethnobotany and Phytopharmacology of Avena sativa: A Qualitative Review. Sciences of Phytochemistry, 2(1): 56-74. e-ISSN 2830-7259.
  • Saha A, Choudhury AAK, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, Singh UP, Bhat HR. (2023) Molecular docking and antimalarial evaluation of hybrid para-aminobenzoic acid 1,3,5 triazine via inhibition of Pf-DHFR. j biomol struct dyn.  (IF-5.23) DOI: 10.1080/07391102.2023.2208207. ISSN:1538-0254 
  • Jamir L, Ghosh SK, Bhat HR, Chaudhary SK, Shakya A. (2023) Preclinical assessment of safety profile of hydro-alcoholic extract of Entada phaseoloides L. Merr seed kernels. S. Afr. J. Bot. 156: 223-233. (IF-3.11) ISSN: 0254-6299 https://doi.org/10.1016/j.sajb.2023.03.020
  • Ansari SH, Sahu S, Shakya A, Ghosh SK, Singh UP, Bhat HR (2023) Design, Synthesis, Antibacterial Activity and SAR Study of Some Novel Aminoquinoline-triazine Conjugates. Letter in drug Design and discovery. 20(3): 304-316. DOI:  10.2174/1570180819666220420084401. (IF-1.15) ISSN: 1573-4099.  
  • Adhikari N, Choudhury AAK, Shakya A, Ghosh SK, Patgiri SJ, Singh UP, Bhat HR. (2023) Design and development of novel N-(4-aminobenzoyl)-L-glutamic acid conjugated 1,3,5-triazine derivatives as Pf-DHFR inhibitor: An in-silico and in-vitro study. J Biochem Mol Toxicol. e23290. (IF-3.64) ISSN: 1099-0461. DOI: 10.1002/jbt.23290
  • Sarma R, Shakya A, Karmakar A, Ghosh SK, Bhat HR, Ghimire N, and Rahman Obaidur R. (2023) A Review Of Preclinical Tools To Validate Anti-Diarrheal Agents, Current Reviews in Clinical and Experimental Pharmacology 2023; 18: 1-14. ISSN: 2772-4336 https://dx.doi.org/10.2174/2772432818666221121113622
  • Sarma R, Ghimire N, Rahman O, Jamir L, Chaudhary SK, Singh, S, Bhat, HR, Ghosh, SK, Shakya A. (2022) Subchronic toxicity study of the characterized hydroalcoholic extract of Paederia foetida (L.) leaves in swiss albino mice. South African Journal of Botany, 151, (A), 544-554. (IF-3.11)  ISSN:0254-6299, https://doi.org/10.1016/j.sajb.2022.10.037.
  • Adhikari N, Choudhury AAK, Shakya A, Ghosh SK, Patgiri SJ, Singh UP, Bhat HR. (2022) Molecular docking and antimalarial evaluation of novel N-(4-aminobenzoyl)-l-glutamic acid conjugated 1,3,5-triazine derivatives as Pf-DHFR inhibitors. 3 Biotech. 12(12):347 (IF-2.89) ISSN: 2190-5738) DOI: 10.1007/s13205-022-03400-2.
  • Gahtori A, Pargaien A, Ghosh SK, Bhat HR, Kumar V, Singh UP, Gahtori P. (2022) Implicit, Intrinsic, Extrinsic, and Host Factors Attributing the COVID-19 Pandemic. Part 3-Host Factor GDP: A Systematic Analysis. Research Square, DOI: https://doi.org/10.21203/rs.3.rs-1498170/v1
  • Ali F, Alom S, Shakya A, Ghosh SK, Singh UP, Bhat HR (2022) Implication of in-silico studies in Search of Novel Inhibitors Against SARS-CoV-2. Archiv der Pharmazie. (IF-3.75) doi: 10.1002/ardp.202100360
  • Shakya A, Chikhale RV, Bhat HR, Alasmary FA, Almutairi TM, Ghosh SK, Alhajri HM, Alissa SA, Nagar S, Islam MA. (2021) Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors. Mol Divers.1–14.(IF-2.94)doi: 10.1007/s11030-021-10209-3.
  • Pande A, Manchanda M, Bhat HR, Bairy PS, Gahtori P (2021) Molecular Insights into a Mechanism of Resveratrol Action Using Hybrid Computational Docking/CoMFA and Machine LearningApproach. j biomol struct dyn. 8, 1-15 (IF-3.22)  ISSN: 1538-0254 https://doi.org/10.1080/07391102.2021.1910572
  • Kashyap A., Choudhury AA, Saha A, Adhikari N, Ghosh S.K., Shakya A., Patgiri SJ, Bhattacharyya DR, Singh UP, Bhat HR. (2021) Microwave assisted synthesis of hybrid PABA-1,3,5-triazine derivatives as antimalarial agent. J Biochem Mol Toxicol. 35(9):e22860. doi: 10.1002/jbt.22860.  (IF-3.64) ISSN: 1099-0461
  • Mandal MK, Ghosh S, Naesens L, Bhat HR, Singh UP (2021) Facile synthesis, antimicrobial and antiviral evaluation of novel substituted phenyl 1,3-thiazolidin-4-one sulphonyl derivatives. Bioorg chem. 114:105153. doi: 10.1016/j.bioorg.2021.105153. (IF-5.27)
  • Singh S, Mandal MK, Masih A, Saha A, Ghosh SK, Bhat HR, Singh UP (2021) 1,3,5-Triazine: A versatile pharmacophore with diverse biological activities. Archiv der Pharmazie. 354(6):e2000363. (IF-3.75) doi.org/10.1002/ardp.202000363           
  • Gogoi P, Shakya A, Ghosh, SK, Gogoi N, Gahtori P, Singh N, Bhattacharyya DR, Singh UP, Bhat HR (2021) In Silico Study, Synthesis and Evaluation of Antimalarial Activity of Hybrid Dimethoxy Pyrazole 1,3,5-Triazine Derivatives. J Biochem Mol Toxicol. 35(3): e22682 (IF-3.60) ISSN: 1099-0461 https://doi.org/10.1002/jbt.22682
  • Masih A, Agnihotri AK, Srivastava JK, Pandey N, Bhat HR, Singh UP. (2021) Discovery of novel pyrazole derivatives as a potent anti‐inflammatory agent in RAW264.7 cells via inhibition of NF‐ĸB for possible benefit against SARS‐CoV‐2. J Biochem Mol Toxicol. 35(3): e22656 (IF-3.60) ISSN: 1099-0461. https://doi.org/10.1002/jbt.22656
  • Masih A, Singh S, Agnihotri AK, Shrivastava JK, Bhat HR, Singh UP. (2021) Discovery of novel 1,3,5-triazine as adenosine A2A receptor antagonist for benefit in Parkinson’s Disease. J Biochem Mol Toxicol. 35(3):e22659 (IF-3.60) ISSN: 1099-0461 https://doi.org/10.1002/jbt.22659
  • Mandal MK, Ghosh S, Bhat HR, Naesens L, Singh UP (2020) Synthesis and biological evaluation of substituted phenyl azetidine-2-one sul-phonyl derivatives as potential antimicrobial and antiviral agents. Bioorg chem. 104: 104320. (IF-4.83) ISSN: 0045-2068 https://doi.org/10.1016/j.bioorg.2020.104320
  • Shakya A, Chaudhary SK, Bhat HR, Ghosh SK. (2020) Acute and sub-chronic toxicity studies of Benincasa hispida (Thunb.) cogniaux fruit extract in rodents. Regul Toxicol Pharmacol. 118:104785. (IF-2.65) ISSN: 0273-2300 doi: 10.1016/j.yrtph.2020.104785.
  • Masih A, Singh S, Agnihotri AK, Shrivastava JK, Bhat HR, Singh UP. (2020) Design and development of 1,3,5-triazine-thiadiazole hybrids as potent adenosine A2A receptor (A2AR) antagonist for benefit in Parkinson's Disease. Neurosci Lett. (IF-2.2) ISSN: 0304-3940. https://doi.org/10.1016/j.neulet.2020.135222
  • Masih A, Shrivastava JK, Bhat HR, Singh UP. (2020) Potent antibacterial activity of dihydydropyrimidine-1,3,5-triazines via inhibition of DNA gyrase and antifungal activity with favourable metabolic profile. Chem Biol Drug Des. 2020; doi: 10.1111/cbdd.13695. (IF-2.54) ISSN: 1747-0277
  • Adhikari N, Kashyap A., Shakya A., Ghosh S.K., Bhattacharyya D.R., Bhat H.R., Singh U.P. (2020) Microwave assisted synthesis, docking and antimalarial evaluation of hybrid PABA-substituted 1,3,5-triazine derivatives. J.Heterocycl. Chem. 57 (6), 2389-2399. (IF-1.48) ISSN: 1943-5193.
  • Bhat H.R., Masih A., Shakya A., Ghosh S.K., Singh U.P. (2020) Design, synthesis, anticancer, antibacterial and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives. J.Heterocycl. Chem. 57 (1), 390-399. https://doi.org/10.1002/jhet.3791 (IF-1.48) ISSN: 1943-5193
  • Das A.,  Shakya A.,  Ghosh S.K.,  Singh U.P.,  Bhat H.R. (2020) A Review of Phytochemical and Pharmacological Studies of Inula Species. Curr Bioact Compd. 16(5), 557-567. DOI : 10.2174/1573407215666190207093538. ISSN:1875-6646
  • Shakya A., Chaudary S.K., Garabadu D.,  Bhat H.R.,  Kakoti B.B., Ghosh S.K. (2020) A Comprehensive Review on Preclinical Diabetic Models. Curr DiabetesRev.16(2):104-116.ISSN:1875-6417 doi : 10.2174/1573399815666190510112035
  • Das A., Ghosh S.K., Bhat H.R., Kalita J., Kashyap A., Adhikari N. (2020) In silico study, synthesis and antimalarial evaluation of hybrid phenyl thiazole 1,3,5-triazine derivatives. Curr Bioact Compd. 16(5), 639-653. ISSN:1875-6646. DOI : 10.2174/1573407215666190308154139
  • Zothantluanga J.H., Lalnunpuii H.S., Bhat H.R., Shakya A. (2019) Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach. Science vision. 19 (4), 120–133. ISSN: 0975-6175(print) https://doi.org/10.33493/scivis.19.04.02
  • Shakya A., Bhat H.R., Ghosh S.K. (2019) Assessment of Neurobehavioral Properties of Hydroalcoholic Extract of Benincasa hispida (Thunb.) Cogn. Fruit Pulp in Mice. Journal of Biologically Active Products from Nature. 2019; 9(4), 299-310. [ISSN: 2231-1866].
  • Shakya, A., Chaudary, S.K., Bhat, H.R., Gogoi, N., Ghosh, S.K. (2019) A Rapid HPTLC Method to Estimate Quercetin in Benincasa hispida (Thunb.) Cogn. Fruit Pulp. Journal of Planar Chromatography. 2019; 32(6), 467-474. [ISSN: 1789-0993; (IF: 0.826).
  • Shakya A., Gogoi N., Chaudhary S.K., Bhat H.R., Ghosh S.K. (2019) Development and Validation of a High-Performance Thin-Layer Chromatography Method for the Quantification of Rutin in the Fruit Pulp of Benincasa hispida (Thunb.) Cogniaux. JPC-J PLANAR CHROMAT. 32 5, 371–377. ISSN: 0933-4173 (IF-0.8)
  • Sahu S., Ghosh S.K., Gahtori P., Singh U.P., Bhattacharyya D.R., Bhat H.R. (2019) In silicoADMET study, Docking, Synthesis and Antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHFR inhibitor. Pharmacology report. DOI: 1016/j.pharep.2019.04.006. ISSN: 1734-1140  (IF-2.787)
  • Das A., Chaudary S.K., Bhat H.R., Shakya A. (2018) cuphea carthagenensis: a review of its ethnobotany, pharmacology and phytochemistry. Bulletin of Arunachal Forest Research, Vol. 33(2), xx-xx: 2018. ISSN (print): 0970-9487.
  • Singh, U.P., Bhat H.R. (2018) Discovery of 1,3,5-triazine-thiazoles (DDTR-502) as potent A2A antagonist/MAO-B inhibitor for the treatment of Parkinson’s disease. Parkinsonism & Related Disorders. 46(2), e39-e40. ISSN: 1353-8020 (IF-4.48) .
  • Shakya A., Bhat H.R., Ghosh S.K. (2017) Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent.Curr Drug Discov Technol.ISSN: 1570-1638. Doi: 10.2174/1570163814666170727130003
  • Kashyap A., Adhikari N., Das A., Shakya A., Ghosh S.K., Singh U.P., Bhat H.R. (2017)Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives.Curr Drug Discov Technol.ISSN: 1570-1638. DOI: 10.2174/1570163814666170911144036
  • Shrivastava J.K., Pillai G.G., Bhat H.R., Verma A.,Singh U.P. (2017) Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase. Nature Sci. Rep. 7: 5851. doi:10.1038/s41598-017-05934-5.  ISSN 2045-2322 (IF-5.22)
  • Singh U.P., Shrivastava J.K., Verma A., Bhat H.R. (2017)Targeting immune and non-immuno synovitis by 1,3,5-TRIAZINE-THIAZOLE via dual inhibition of NF-KB and EGFR-TKS for possible benefit in rheumatoid arthritis. Annals of the Rheumatic Diseases. 76(2) 1072-1073.ISSN:0003-4967 (IF-12.811)
  • Singh U.P., Shrivastava J.K., Verma A., Bhat H.R. (2017)Discovery of 1,3,5-triazine-monastrol based novel EGFR-tyrosine kinase inhibitor against human lung carcinoma.Annals of Oncology. 28(2): ii9-ii13. ISSN:1569-8041 (IF-9.26)
  • Singh UP, Srivastava JK, Bhat HR (2017) Novel monastrol derivatives exert potent anti-breast cancer activity via inhibition of ubiquitin conjugating enzyme Rad6B.European Journal of Cancer.72(1): S36–S37.ISSN: 0959-8049 (IF-6.16).
  • Singh UP, Bhat HR (2017) PUB081 Discovery of 1,3,5-Triazine Based Novel EGFR-Tyrosine Kinase Inhibitor against Human Lung Carcinoma. Journal of Thoracic Oncology.12 (1): S1494–S1495. ISSN: 1556-0864 (IF-5.04).
  • Bhat, HR , Singh, UP,  Yadav, PS,  Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2016) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., 2016; 9: S625-S631. (IF- 3.61) ISSN: 1878-5352
  • Singh UP, Srivastava JK, Bhat HR (2016) Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against Non-small cell lung cancer (NSCLC). Annals of Oncology 27(9):50. (IF- 9.26) ISSN: 1569-8041
  • Sahu S, Ghosh SK, Kalita J, Dutta M, Bhat HR (2016) Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS. Exp Parasitol.163:38-45. (IF- 1.85) ISSN: 1090-2449.
  • Singh UP, Srivastava JK, Bhat HR (2015) Structure-based optimization and discovery of novel 1,3,5-triazine derivatives as bacterial translation inhibitor with favourable metabolic fate. Antimicrob Resist Infect Control., 2015; 4(Suppl 1): I2.
  • Srivastava JK, Awatade NT, Bhat HR, Kmit A, Mendes K, Ramos M, Amaral MD, Singh UP (2015) Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity. RSC Adv., 5, 88710-88718.
  • Bhat HR, Singh UP, Thakur A, Ghosh SK, Gogoi K, Prakash A, Singh RK (2015) Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoquinoline-1,3,5-triazine derivatives. Exp Parasitol.157, 59-67. DOI:10.1016/j.exppara. 2015.06.016 (IF- 1.85)
  • Singh JK, Dubey P, Singh S, Bhat HR, Kumawat MK, Singh UP, (2015) Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 (DPP-4) inhibitor targeting S1 pocket for the treatment of type 2 diabetes along with antibacterial activity. RSC Adv ,5, 14095-14102. (IF- 3.70)
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi K, Prakash A, Singh RK (2015) Synthesis, docking, in vitro and in vivo antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives against wild and mutant malaria parasites, Chemical Biology & Drug Design, DOI: 10.1111/cbdd.12490. (IF- 2.50)
  • Singh B, Bhat HR, Kumawat MK, Singh UP (2014) Structure-guided discovery of 1,3,5-triazine-pyrazole conjugates as antibacterial and antibiofilm agents against pathogens causing human diseases with favourable metabolic fate. Bioorganic & Medicinal Chemistry Letters, 24, 3321-3325, DOI: 10.1016/j.bmcl.2014.05.103 (IF- 2.42)
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi K, Prakash A, Singh RK. (2014). 4-Aminoquinoline-1,3,5-triazine: Design, synthesis, in vitro antimalarial activity and docking studies.ChemInform Abstract, 45, DOI: 10.1002/chin.201404181
  • Pathak P, Thakur A, Bhat HR, Singh UP (2014) Hybrid 4-Aminoquinoline-1,3,5-triazine Derivatives: Design, Synthesis, Characterization, and Antibacterial Evaluation, Journal of Heterocyclic Chemistry, DOI 10.1002/jhet.2210 (IF- 0.78)
  • Singh UP, Bhat HR, Verma A, Kumawat MK, Singh RK (2013) Phenylhydrazone bearing pyrazole and pyrimidine scaffolds: Design and discovery of novel class of Non-nucleoside Reverse Transcriptase Inhibitor (NNRTIs) and antibacterial agent. RSC Adv., 3:17335-17348. DOI: 10.1039/C3RA41604F (IF- 3.70)
  • Singh UP, Bhat HR, Kumawat MK, Singh RK. (2013) Utilisation of Home Laundry Effluent (HLE) as a catalyst for the expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones. SpringerPlus., 2:466. DOI:10.1186/2193-1801-2-466.
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi Kabita, Prakash A, Singh RK. (2013). 4-Aminoquinoline-1,3,5-triazine:Design, synthesis, in vitro antimalarial activity and docking studies. New J. Chem.,37: 2654-2662. DOI: 10.1039/C3NJ00317E.(IF-3.15)
  • Bhat H.R., Kumar P., Ghosh S.K., Singh U.P. (2013) Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route. Med Chem Res., 22:5056-5065. DOI:10.1007/s00044-013-0521-8 (IF-1.62)
  • Kumar S, Bhat HR, Kumawat MK, Singh UP. (2013) Design and one-pot synthesis of hybrid thiazolidin-4-one-1,3,5-triazines as potent antibacterial agent against human disease causing pathogens. New J. Chem., 37:581-584. DOI: 10.1039/C2NJ41028A (IF-3.15)
  • Bhat H.R., Singh U.P., Gahtori P., Ghosh S.K., Gogoi K., Prakash A., Singh R.K. (2013) Antimalarial activity and docking studies of novel bifunctional hybrids derived from 4-aminoquinoline and 1,3,5- triazine against wild and mutant malaria parasites as pf-DHFR inhibitor. RSC Adv., 3:2942-2952. DOI: 10.1039/C2RA21915H (IF- 3.70)
  • Singh UP, Bhat HR, Gahtori P, Singh RK. (2013) Hybrid thiazole-1,3,5-triazines target cytosolic Leucyl-tRNA synthetase for antifungal action revealed by molecular docking studies. In Silico Pharmacology, 1: 3. DOI:10.1186/2193-9616-1-3
  • Singh UP, Bhat HR, Singh RK. (2013) Ceric ammonium nitrate catalysed expeditious one-pot synthesis of 1,3-thiazine as IspE kinase inhibitor of Gram-negative bacteria using polyethylene glycol (PEG-400) as an efficient recyclable reaction medium. C.R.Chim., 16:462-468. DOI: 10.1016/j.crci.2012.11.019 . (IF-1.48)
  • Bhat H.R., Gupta, S.K., Singh U.P. (2012) Discovery of potent, novel antibacterial hybrid conjugates from4-aminoquinoline and 1,3,5-triazine: design, synthesis and antibacterial evaluation. RSC Adv.,2: 12690–12695. DOI: 10.1039/C2RA22353H (IF- 3.70)
  • Dubey V, Pathak M, Bhat HR, Singh UP (2012) Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge.Chem Biol Drug Des., 80(4):598-604. DOI:10.1111/j.1747-0285.2012.01433.x. (IF- 2.50)
  • Singh UP, Pathak M, Dubey V, Bhat HR, Gahtori P, Singh RK. (2012) Design, Synthesis, Antibacterial Activity, and Molecular Docking Studies of Novel Hybrid 1,3-Thiazine-1,3,5-Triazine Derivatives as Potential Bacterial Translation Inhibitor.Chem Biol Drug Des., 80:572-83. DOI:10.1111/j.1747-0285.2012.01430.x (IF- 2.50)
  • Singh, U.P., Bhat, H.R., Gahtori, P. (2012) Antifungalactivity, SAR and physicochemicalcorrelation of some thiazole-1,3,5-triazinederivatives. Journal de Mycologie Médicale. 22:134–141. (IF- 0.4)
  • Gahtori P, Ghosh SK, Parida P, Prakash A, Gogoi K, Bhat HR, Singh UP. (2012) Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: a novel and potential antifolate lead for Pf-DHFR-TS inhibition.Exp Parasitol. 130:292-299.(IF- 1.85)
  • Gahtori, P., Ghosh, S.K., Singh, B., Singh, U.P., Bhat, H.R., Uppal, A., (2012) Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-striazines. Saudi Pharm J., 20:35–43.   (IF- 1.00)
  • Bhat HR, Ghosh SK, Prakash A, Gogoi K, Singh UP. (2012) In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives. Lett Appl Microbiol., 54:483-486. (IF- 1.74)
  • Ghosh, S.k; Saha, A; Hazarika, B; Singh, UP; Bhat, HR; Gahtori, P. (2012) Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di- and Tri-Substituted 1,3,5-Triazines. Letters in Drug Design & Discovery., 9:329-335. (IF- 0.96)
  • Yadav PS, Kumar, V, Singh UP, Bhat, HR, Mazumder B (2012) Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol. Saudi Pharm J.,21:77-84.
  • Bhat, HR, Singh, UP, Yadav, PS, Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2011) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., doi.org/10.1016/j.arabjc.2011.07.001. (IF- 2.68)
  • Singh UP, Singh RK, Bhat HR, Subhashchandra YP, Kumar V, Kumawat MK, et al. (2011) Synthesis and antibacterial evaluation of series of novel tri-substituted-s-triazine derivatives. Med Chem Res., 20:1603-1610. (IF- 1.62)
  • Kumar V, Yadav PS, Singh UP, Bhat HR, Zaman K, Ali M (2011) Isolation of new racemicsugar (D/L galacturonic acid) from leaves of Paederia foetida Linn. Nature Preceedings. DOI: 10.1038/npre.2011.5752.1
  • Kumar V, Yadav PS, Singh UP, Bhat HR, Rana A, Kamaruz ZM (2010)Pharmacognostical evaluation of Cuscuta reflexa Roxb.Phcog J., 2:74-82.
  • Kumar V., Yadav P.S., Singh U.P., Bhatt H.R., Zaman K. (2009) Pharmacognostical and Phytochemical study on Leaves of Peaderia foetida linn. International Journal of PharmTech Research1; 3:918-920.
  • Kumar P., Bhat H.R., DasA. (2008) Synthesis of N-[4'-(4''-substituted Phenyl)-thiazol-2'-yl]-[1,3,5]-triazine-2-amine series as novel antibacterial agents Indian J. Pharm. Sci., 7(2) 107-111. DOI: 10.4103/0250-474X.51960 (IF-0.29)

 

Abstracts Published in Proceedings’:

  • Bhat H.R., Ghosh S.K., Shakya A., Singh U.P., Patgiri S.J. Hybrid pyrazole s-triazine derivatives: Design, synthesis and antimalarial evaluation. Two days International Seminar on Emerging trends in Chemical Science (ETCS-23) at Department of Chemistry, H.V.M. (P.G.) College, Raisi, Haridwar, U.K., March 17, 18, 2023.
  • Dutta S., Choudhary A., Ghosh S.K., Bhat H.R. LDL-C Target in CVS disease is promised by inclisiran. Two days 2nd National Seminar on Novel Innovations in Biomedical Sciences (NIBS)-2023. at Department of Pharmacy, NEMCARE group of institutions, Gauhati, Assam, March 14, 15, 2023. NIBS/23/PP/005
  • Kalita T., Ghosh S.K., Bhat H.R. In silico screening of novel triazine derivatives as possible anti-alzheimer’s agents. Two days 2nd National Seminar on Novel Innovations in Biomedical Sciences (NIBS)-2023. at Department of Pharmacy, NEMCARE group of institutions, Gauhati, Assam, March 14, 15, 2023. NIBS/23/PP/067
  • Bhat H.R., Devanath B., Shakya A., Ghosh S.K., Singh U.P. Design, Synthesis, and In-Vitro Antimalarial Activity Evaluation of Hybrid Pyridine-Pyrazole s-triazine Derivatives. Two days National Seminar on “Integration of Traditional Herbal Medicines of NE India in Clinical Practice: Importance, Challenges and Future" at Department of Pharmaceutical Sciences, Dibrugarh University and RIWATCH, India. November 04-05, 2022.
  • Islama M.A., Bhat HR. “A Systematic Review on Medicinal Plants as Nootropic agents” Two days National Seminar on “Integration of Traditional Herbal Medicines of NE India in Clinical Practice: Importance, Challenges and Future" at Department of Pharmaceutical Sciences, Dibrugarh University and RIWATCH, India. November 04-05, 2022.
  • Choudhary A., Debnath B., Bhat H.R.” Antimalarial drugs derived from plant sources and its current scenerio” Two days National Seminar on “Integration of Traditional Herbal Medicines of NE India in Clinical Practice: Importance, Challenges and Future" at Department of Pharmaceutical Sciences, Dibrugarh University and RIWATCH, India. November 04-05, 2022.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Patgiri S. J. Global Indian Scientists & Technocrats Fest (GIST) (IISF-2021) at Panaji, Goa. Ministry of Earth Sciences, New Delhi, India. December 10-13, 2021 
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Patgiri S. J. Design, synthesis of pyrazole substituted 1,3,5-triazine derivatives as antimalarial. International Virtual Conference on “Advance in chemical Sciences (ACS 2021)” at Harsh PG College, Haridwar, India. December 21-22, 2021.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. in-vitro antimalarial evaluation and synthesis of pyrazole substituted s-triazine derivatives. International Virtual Conference on “Recent Advances in Organic, Medicinal and Biological Chemistry” at Vellore Institute of Technology, Chennai, India. July 8-9, 2020; P-55.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. Design, Synthesis and In-Vitro Antimalarial Evaluation of 1,3,5-triazine derivatives. Young Scientists' Conference (YSC) (IISF-2019) at Kolkata. Ministry of Earth Sciences, New Delhi, India. November 05-07, 2019.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. Design, Synthesis and Antimalarial Evaluation of hybrid dimethoxy pyrazole s-triazine derivatives. National Seminar on ‘Current Research in Drug Discovery and Development’ Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. November 13-14, 2019: P-07.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. Hybrid 4-Aminoquinoline 1,3,5-triazine: Synthesis and in-vitro Antimalarial Evaluation. National Seminar on ‘Emerging Global Trends in Pharmaceutical Nanotechnology’ Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. November 23-24, 2018: P-07.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Kashyap A., Bhattacharya D.R. Design, Synthesis and Antimalarial activity Evaluation of 4-Aminoquinoline s-traizine derivative. Young Scientists' Conference (YSC) (IISF-2018) at Lucknow. Ministry of Earth Sciences, New Delhi, India. October 05-06, 2018.
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antibacterial Evaluation of hybrid 4-aminoquinoline Triazine Derivatives. National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 19.
  • Shakya, A., Bhat, H.R., Ghosh, S.K. A Report on Phytotherapeutic aspect of Benincasa hispida (Thunb.) National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 40
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antibacterial Evaluation of hybrid 4-aminoquinoline Triazine Derivatives. National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 19.
  • Shakya, A., Bhat, H.R., Ghosh, S.K. A Report on Phytotherapeutic aspect of Benincasa hispida (Thunb.) National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 40.
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antimalarial Evaluation of Tri-substituted 1,3,5-Triazine Derivatives. International symposium on contemporary facets in organic synthesis 2017 (CFOS2017) at IIT Roorkee, India. December 22-24, 2017.
  • Shakya, A., Mahanta, S., Bhat, H.R., Ghosh, S.K. Protective effect of the Acmella paniculata against ethanol induced liver and stomach pathologies: a preclinical study. Conference proceedings of 7th Euro-India International Conference on Holistic Medicine (ICHM-2017): Kottayam, Kerala, India. September 15-17, 2017.
  • Shakya, A., Mahanta, S., Bhat, H.R., Ghosh, S.K. Protective effect of the Acmella paniculata against ethanol induced liver and stomach pathologies: a preclinical study. 7th Euro-India International Conference on Holistic Medicine (ICHM-2017): Kottayam, Kerala, India. September 15-17, 2017.
  • Bhat H.R., SinghU.P., Ghosh S.K.Synthesis and antibacterial and antifungal evaluation of Novel 4-Aminoquinoline semicarbazide conjugates.National Conferences onEmerging Trends in Pharmaceutical & Biotechnological Research at Anand college of pharmacy Agra, India, November 06-07, 2015.
  • Singh U.P., Srivastava J.K., Bhat H.R. Discovery of Novel Diaryltriazines (DATAs) as Non-nucleoside Reverse Transcriptase inhibitors via Extension into the Entrance channel of HIV-1 Reverse Transcriptase. international conferences on 15th European Aids Conference, Barcelona, Spain 21-24 October 2015. PE10/1 PP. 180.
  • Verma A., Bhat H.R., Singh U.P., Design and Discovery of potent Hybrid 1,3,5-triazines-1,3-Thiazine Analogs Clubbed via Amide Bridge: A Novel Lead for next generation NNRTI. International conferences on 15th European Aids Conference, Barcelona, Spain 21-24 October 2015. PE10/2 PP. 181.
  • Oral Presentation on the topic of “Design, synthesis and antimalarial activity of Hydrid 4-aminoquinoline 1,3,5-triazine derivatives” International workshop on the topic “Discovery of new drugs against Malaria” at International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi from 27th January to 6th February 2015.
  • Bhat H.R., Singh U.P., Gahtori P., Ghosh S.K., Prakash A., Kavita K., Singh R.K. Hybrid 4-aminoquinoline-1,3,5-triazine derivatives: Design, synthesis, in-vitro antimalarial activity and docking studies against wild & mutant malaria parasites. National conferences on chemistry at the interface of innovative researches in sciences & technology at university of Allahabad. India, Feb 27-28, 2014, P-41, 42.
  • Singh B., Bhat H.R., Kumawat M.K., Singh U.P. Structure-guided synthesis of 1,3,5-triazine–pyrazole conjugates as potent antibacterial and antibiofilm inhibitory activity against pathogens causing human diseases with favorable metabolic fate.National conferences on chemistry at the interface of innovative researches in sciences & technology at university of Allahabad. India, Feb 27-28, 2014, P- 40.
  • Bhat H.R., Singh U.P., Yadav P.K., Ghosh S.K., Prakash A., Mahanta J. Synthesis and Molecular Docking Studies of Hybrid 4-aminoquinoline s-triazines. International Conference on MedChem 2011 at IICT/NIPER Hyderabad. India, Feb 25 and 26, 2011, P-14
  • Singh U.P., Bhat H.R., Pathak M.K., Dubey V., Yadav P.K., Singh R.K., (2011) Molecular Docking Studies of Hybrid 1,3-thiazine-s-1,3,5-triazene Derivatives Against r-RNA: Novel Bacterial Translation Inhibitors. International Conference on MedChem 2011 at IICT/NIPER Hyderabad. India, Feb 25 and 26, 2011, P-12
  • Singh U.P., Bhat H.R., Kumar V., Yadav P. S., Chetia D., Ghosh S. K. “Herpes simplex virus - Antiviral drug resistance” National Conference on Emerging Trends in Pharmaceutical Sciences, Jammu University, Shrinagar, Jammu, 8-9 March 2009.
  • Bhat H.R., Kumar V., Gahtori P., Das A., Chetia D., PrakashA., MahantaJ. Synthesis and Antimalarial activity evaluation of some analogues of 7-chloro-N-[3-(4,6-diamino-1,3,5-triazin-2-ylamino) propyl]quinoline-4-amine derivatives. Antimicrobial Resistance: From Emerging Threat to Reality from 23rd-25th March, 2009, at Allahabad Agricultural Institute-Deemed University, Sponsored by WHO, ICAR, ICMR, DST, NABARD, Govt. of India.
  • Gahtori P., Bhat H.R., Ghosh S.K., Singh B. Antimalarial Drug Resistance need of multiple drug therapy.Antimicrobial Resistance: From Emerging Threat to Reality from 23rd-25th March, 2009, at Allahabad Agricultural Institute-Deemed University, Sponsored by WHO, ICAR, ICMR, DST, NABARD, Govt. of India
  • Kumar V., Bhat H.R., Zaman K. In vitro antioxidant properties of Paederia foetida Linn leaf extract. National Seminar on Recent Advances in Chemical Sciences, Dibrugarh University, Dibrugarh 26-27 March 2009.
  • Kumar V., Bhat H.R., Kumar V. Drugs For Sprotsman. National Seminar On Emerging Trends In Noval Drug Delivery System. H.R. Institute Of Pharmacy, Ghaziabad, 27-28 March 2009.
  • Bhat H.R., Kumar V., Gahtori P., Das A., Chetia D., Prakash A., Mahanta J. Synthesis and Antimalarial activity evaluation of 2, 4, 6-trisubstituted traizine derivative. National Conference on Recent Trends in Pharmaceutical Sciences, Anand college of pharmacy Agra 14-15 November, 2009.
  • Yadav P.S., Kumar V., Singh U.P., Bhat H.R., Ahmed D., Mazumder B. Physicochemical characterisation and in-vitro dissolution studies of solid dispersion of Ketoprofen with PVP K30 and D-Mannitol. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Kumar V., Yadav P.S., Singh U.P., Bhat H.R., Ahmed D. Review: Method for Evaluation of in-vitro and in-vivo Antioxidant Activity. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Ahmed D., Singh U.P., Kumar V., Yadav P.S., Bhat H.R., Effect of Rosiglitazone, Atorvastatin and Glimipride on Glycemic control and Lipid Profile on STZ induced NIDDM rats. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Kaithwas G., Singh U.P., Yadav P.S., Kumar V., Bhat H.R., Ahmed D. Diagnosis of Filarial Parasites. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Bhat H.R., Singh U.P., Yadav P.S., Kumar V., Gahtori P., Das A., Chetia D., Prakash A., Mahanta J. Synthesis and Antimalarial activity evaluation of some analogues of 7-chloro-N-[3-(4,6-diamino-1,3,5-triazin-2-ylamino) propyl] quinoline-4-amine derivatives. (Accepted for poster presentation,4th international Symposium on Current trends in drug discovery research Lucknow 17-21 Feb. 2010)
  • Singh U.P., Bhat H.R., Yadav P.S., Kumar V, Kumawat M.K., Gahtori P. synthesis and antibacterical evaluation of series of noval tri-substituted s-triazine derivatives. (Accepted for poster presentation, 4th international Symposium on Current trends in drug discovery research Lucknow 17-21 Feb. 2010)

·          Singh UP, Srivastava JK, Bhat HR (2016) Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against Non-small cell lung cancer (NSCLC). Annals of Oncology 27(9):50. (IF- 9.26) ISSN: 1569-8041

·          Bhat, HR , Singh, UP,  Yadav, PS,  Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2016) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., 2016; 9: S625-S631. (IF- 3.61) ISSN: 1878-5352

·          Sahu S, Ghosh SK, Kalita J, Dutta M, Bhat HR (2016) Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS. Exp Parasitol.163:38-45. (IF- 1.85) ISSN: 1090-2449.

Sponsored Projects

Book Chapter Published

  1. Bhattacharjee B., Deka B., Shivavedi N., Bhat H.R., Sinha S.K., Ghosh S.K., Shakya A. (2023). Neuroprotective Role of Medicinal Plants from North Eastern Region of India. Singh S.P.,Birla H., Keswani C. (eds) Traditional Medicine for Neuronal Health. Bentham science. Page No. 103-128. Doi: 10.2174/97898150401971230101
  2. Deka, B., Bhattacharjee B., Shivavedi N., Singh G.K., Bhat H.R., Ghosh S.K., Shakya A. (2023). Parkinson's Disease: A Phytotherapeutic Prospective. Traditional Medicine for Neuronal Health. Singh S.P.,Birla H., Keswani C. (eds) Traditional Medicine for Neuronal Health. Bentham science page No. 1-23. Doi: 10.2174/97898150401971230101
  3. Shakya, A., Sarma, R., Ghimire, N., Ghosh, S.K., Bhat, H.R., Rahman, O. (2022). Therapeutic Drug Monitoring and Toxicology of Immunosuppressant. In: Amponsah, S.K., Pathak, Y.V. (eds) Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-031-12398-6_12.

 

Profile

Profile

Education:

  1. Bachelor’s Degree: B. Pharm Mohanlal Sukhadia University, Udaipur, Rajasthan 2005
  2. Master’s Degree: M.Pharm Dibrugarh University, Assam, 2008
  3. Ph.D.: Pharmaceutical Sciences Dibrugarh University, Assam, 2014
  4. Other:
    1. GATE 2006 IIT Kharagpur
    2. GATE 2007 IIT Kanpur

Professional Experience: 14.7 Years

 

Areas of Interest/ Specialization:

  • Medicinal Chemistry, Antimalarial Drug Development, Antibacterial Activity, Anti Cancer activity

 

Project undertaken: 

Founding Agency

Project Title

Grant No.

PI/Co-PI
DST

Design, Microwave Assisted Syntheisis and Antmalanal Evaluation of Hybrid Para-Amino- Benzoic Acid-I,3,5-triazine derivatives

EMR/2017/000708

Co-PI
DU

Design, synthesis and anti-Alzheimer activity evaluation of tri-substituted 1,3,5 -triazine derivatives

DU/3183-84

PI
AICTE Design, synthesis and antimalarial evaluation of hybrid pyrazoline substituted 1,3,5-triazine derivatives

8-21/FDC/RPS

(NER)/POLICY-1

/2020-21		 PI

 

Ph.D Scholars:

S.No.

Name

Topic

Status

1.

Ms. Ashmita Saha

Design, microwave assisted synthesis and antimalarial evaluation of hybrid para-amino benzoic acid-1,3,5-triazine derivatives.

On going

 

2.

Ms. Ayesha Aktar

Novel 2,4,6-trisubstituted 1,3,5-triazine derivatives conjugated with para-glutamic acid as potent antifolate for malaria pf-DHFR inhibition.

 Thesis Submitted

3.

Ms. Pooja Patowary

Design, Synthesis and Anti- Alzheimer's Evaluation of Coumarin Derivatives

On going

(24/09/2020)

4.

Ms. Tutumoni Kalita  

Design, synthesis and anti-alzheimer evaluation of novel triazine derivatives

On going (07/03/2022)
5 Mr. Farak Ali Evaluation of Anti-Alzheimer activity in substituted Hydroxymethyl phthalimide 1,3,5-triazine derivatives On going (10/04/2023)

                                                     

                                                                                          

 

Publications

Publications

 

Research Publications:

Article Published:

  • Saha A, Choudhury AAK, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, Singh UP, Bhat HR (2023) In silico screening, synthesis, and antimalarial evaluation of PABA substituted 1,3,5-triazine derivatives as Pf-DHFR inhibitors. Exp Parasitol. 250:108546. (IF-2.13)doi: 10.1016/j.exppara.2023.108546.
  • Gupta A, Bhat HR, Singh UP (2023) Discovery of novel hybrids of Morpholino-1,3,5-triazine-pyrimidine as an anti-diabetic agent in High-fat, Low-dose Streptozotocin-induced diabetes in Wistar rats: An in-vitro, in-silico and in-vivo study. J. Mol. Struct. (IF-3.80) ISSN (online): 0022-2860. DOI: https://doi.org/10.1016/j.molstruc.2023.136478
  • Gupta A, Bhat HR, Singh UP (2023) Discovery of novel 1,3,5-triazine derivatives as an anti-diabetic agent in Wistar rats via inhibition of DPP-4. Future Med Chem. 15(10):829-852  (IF-4.76) ISSN (print): 1756-8919. DOI: 10.4155/fmc-2022-0312
  • Gupta A, Bhat HR, Singh UP (2023) Discovery of Imeglimin-inspired novel 1,3,5-triazine derivatives as an antidiabetic agent in Streptozotocin-induced Diabetes in Wistar rats via inhibition of DPP-4. RSC Med. Chem., 14, 1512-1536 DOI: https://doi.org/10.1039/D3MD00085K  (IF-3.47) ISSN (print): 2632-8682
  • Kumari S, Ali S, Rahman O, Kumar A, Bhat HR, Ghosh SK, Shakya A (2023) Ethnobotany and Phytopharmacology of Avena sativa: A Qualitative Review. Sciences of Phytochemistry, 2(1): 56-74. e-ISSN 2830-7259.
  • Saha A, Choudhury AAK, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, Singh UP, Bhat HR. (2023) Molecular docking and antimalarial evaluation of hybrid para-aminobenzoic acid 1,3,5 triazine via inhibition of Pf-DHFR. j biomol struct dyn.  (IF-5.23) DOI: 10.1080/07391102.2023.2208207. ISSN:1538-0254 
  • Jamir L, Ghosh SK, Bhat HR, Chaudhary SK, Shakya A. (2023) Preclinical assessment of safety profile of hydro-alcoholic extract of Entada phaseoloides L. Merr seed kernels. S. Afr. J. Bot. 156: 223-233. (IF-3.11) ISSN: 0254-6299 https://doi.org/10.1016/j.sajb.2023.03.020
  • Ansari SH, Sahu S, Shakya A, Ghosh SK, Singh UP, Bhat HR (2023) Design, Synthesis, Antibacterial Activity and SAR Study of Some Novel Aminoquinoline-triazine Conjugates. Letter in drug Design and discovery. 20(3): 304-316. DOI:  10.2174/1570180819666220420084401. (IF-1.15) ISSN: 1573-4099.  
  • Adhikari N, Choudhury AAK, Shakya A, Ghosh SK, Patgiri SJ, Singh UP, Bhat HR. (2023) Design and development of novel N-(4-aminobenzoyl)-L-glutamic acid conjugated 1,3,5-triazine derivatives as Pf-DHFR inhibitor: An in-silico and in-vitro study. J Biochem Mol Toxicol. e23290. (IF-3.64) ISSN: 1099-0461. DOI: 10.1002/jbt.23290
  • Sarma R, Shakya A, Karmakar A, Ghosh SK, Bhat HR, Ghimire N, and Rahman Obaidur R. (2023) A Review Of Preclinical Tools To Validate Anti-Diarrheal Agents, Current Reviews in Clinical and Experimental Pharmacology 2023; 18: 1-14. ISSN: 2772-4336 https://dx.doi.org/10.2174/2772432818666221121113622
  • Sarma R, Ghimire N, Rahman O, Jamir L, Chaudhary SK, Singh, S, Bhat, HR, Ghosh, SK, Shakya A. (2022) Subchronic toxicity study of the characterized hydroalcoholic extract of Paederia foetida (L.) leaves in swiss albino mice. South African Journal of Botany, 151, (A), 544-554. (IF-3.11)  ISSN:0254-6299, https://doi.org/10.1016/j.sajb.2022.10.037.
  • Adhikari N, Choudhury AAK, Shakya A, Ghosh SK, Patgiri SJ, Singh UP, Bhat HR. (2022) Molecular docking and antimalarial evaluation of novel N-(4-aminobenzoyl)-l-glutamic acid conjugated 1,3,5-triazine derivatives as Pf-DHFR inhibitors. 3 Biotech. 12(12):347 (IF-2.89) ISSN: 2190-5738) DOI: 10.1007/s13205-022-03400-2.
  • Gahtori A, Pargaien A, Ghosh SK, Bhat HR, Kumar V, Singh UP, Gahtori P. (2022) Implicit, Intrinsic, Extrinsic, and Host Factors Attributing the COVID-19 Pandemic. Part 3-Host Factor GDP: A Systematic Analysis. Research Square, DOI: https://doi.org/10.21203/rs.3.rs-1498170/v1
  • Ali F, Alom S, Shakya A, Ghosh SK, Singh UP, Bhat HR (2022) Implication of in-silico studies in Search of Novel Inhibitors Against SARS-CoV-2. Archiv der Pharmazie. (IF-3.75) doi: 10.1002/ardp.202100360
  • Shakya A, Chikhale RV, Bhat HR, Alasmary FA, Almutairi TM, Ghosh SK, Alhajri HM, Alissa SA, Nagar S, Islam MA. (2021) Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors. Mol Divers.1–14.(IF-2.94)doi: 10.1007/s11030-021-10209-3.
  • Pande A, Manchanda M, Bhat HR, Bairy PS, Gahtori P (2021) Molecular Insights into a Mechanism of Resveratrol Action Using Hybrid Computational Docking/CoMFA and Machine LearningApproach. j biomol struct dyn. 8, 1-15 (IF-3.22)  ISSN: 1538-0254 https://doi.org/10.1080/07391102.2021.1910572
  • Kashyap A., Choudhury AA, Saha A, Adhikari N, Ghosh S.K., Shakya A., Patgiri SJ, Bhattacharyya DR, Singh UP, Bhat HR. (2021) Microwave assisted synthesis of hybrid PABA-1,3,5-triazine derivatives as antimalarial agent. J Biochem Mol Toxicol. 35(9):e22860. doi: 10.1002/jbt.22860.  (IF-3.64) ISSN: 1099-0461
  • Mandal MK, Ghosh S, Naesens L, Bhat HR, Singh UP (2021) Facile synthesis, antimicrobial and antiviral evaluation of novel substituted phenyl 1,3-thiazolidin-4-one sulphonyl derivatives. Bioorg chem. 114:105153. doi: 10.1016/j.bioorg.2021.105153. (IF-5.27)
  • Singh S, Mandal MK, Masih A, Saha A, Ghosh SK, Bhat HR, Singh UP (2021) 1,3,5-Triazine: A versatile pharmacophore with diverse biological activities. Archiv der Pharmazie. 354(6):e2000363. (IF-3.75) doi.org/10.1002/ardp.202000363           
  • Gogoi P, Shakya A, Ghosh, SK, Gogoi N, Gahtori P, Singh N, Bhattacharyya DR, Singh UP, Bhat HR (2021) In Silico Study, Synthesis and Evaluation of Antimalarial Activity of Hybrid Dimethoxy Pyrazole 1,3,5-Triazine Derivatives. J Biochem Mol Toxicol. 35(3): e22682 (IF-3.60) ISSN: 1099-0461 https://doi.org/10.1002/jbt.22682
  • Masih A, Agnihotri AK, Srivastava JK, Pandey N, Bhat HR, Singh UP. (2021) Discovery of novel pyrazole derivatives as a potent anti‐inflammatory agent in RAW264.7 cells via inhibition of NF‐ĸB for possible benefit against SARS‐CoV‐2. J Biochem Mol Toxicol. 35(3): e22656 (IF-3.60) ISSN: 1099-0461. https://doi.org/10.1002/jbt.22656
  • Masih A, Singh S, Agnihotri AK, Shrivastava JK, Bhat HR, Singh UP. (2021) Discovery of novel 1,3,5-triazine as adenosine A2A receptor antagonist for benefit in Parkinson’s Disease. J Biochem Mol Toxicol. 35(3):e22659 (IF-3.60) ISSN: 1099-0461 https://doi.org/10.1002/jbt.22659
  • Mandal MK, Ghosh S, Bhat HR, Naesens L, Singh UP (2020) Synthesis and biological evaluation of substituted phenyl azetidine-2-one sul-phonyl derivatives as potential antimicrobial and antiviral agents. Bioorg chem. 104: 104320. (IF-4.83) ISSN: 0045-2068 https://doi.org/10.1016/j.bioorg.2020.104320
  • Shakya A, Chaudhary SK, Bhat HR, Ghosh SK. (2020) Acute and sub-chronic toxicity studies of Benincasa hispida (Thunb.) cogniaux fruit extract in rodents. Regul Toxicol Pharmacol. 118:104785. (IF-2.65) ISSN: 0273-2300 doi: 10.1016/j.yrtph.2020.104785.
  • Masih A, Singh S, Agnihotri AK, Shrivastava JK, Bhat HR, Singh UP. (2020) Design and development of 1,3,5-triazine-thiadiazole hybrids as potent adenosine A2A receptor (A2AR) antagonist for benefit in Parkinson's Disease. Neurosci Lett. (IF-2.2) ISSN: 0304-3940. https://doi.org/10.1016/j.neulet.2020.135222
  • Masih A, Shrivastava JK, Bhat HR, Singh UP. (2020) Potent antibacterial activity of dihydydropyrimidine-1,3,5-triazines via inhibition of DNA gyrase and antifungal activity with favourable metabolic profile. Chem Biol Drug Des. 2020; doi: 10.1111/cbdd.13695. (IF-2.54) ISSN: 1747-0277
  • Adhikari N, Kashyap A., Shakya A., Ghosh S.K., Bhattacharyya D.R., Bhat H.R., Singh U.P. (2020) Microwave assisted synthesis, docking and antimalarial evaluation of hybrid PABA-substituted 1,3,5-triazine derivatives. J.Heterocycl. Chem. 57 (6), 2389-2399. (IF-1.48) ISSN: 1943-5193.
  • Bhat H.R., Masih A., Shakya A., Ghosh S.K., Singh U.P. (2020) Design, synthesis, anticancer, antibacterial and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives. J.Heterocycl. Chem. 57 (1), 390-399. https://doi.org/10.1002/jhet.3791 (IF-1.48) ISSN: 1943-5193
  • Das A.,  Shakya A.,  Ghosh S.K.,  Singh U.P.,  Bhat H.R. (2020) A Review of Phytochemical and Pharmacological Studies of Inula Species. Curr Bioact Compd. 16(5), 557-567. DOI : 10.2174/1573407215666190207093538. ISSN:1875-6646
  • Shakya A., Chaudary S.K., Garabadu D.,  Bhat H.R.,  Kakoti B.B., Ghosh S.K. (2020) A Comprehensive Review on Preclinical Diabetic Models. Curr DiabetesRev.16(2):104-116.ISSN:1875-6417 doi : 10.2174/1573399815666190510112035
  • Das A., Ghosh S.K., Bhat H.R., Kalita J., Kashyap A., Adhikari N. (2020) In silico study, synthesis and antimalarial evaluation of hybrid phenyl thiazole 1,3,5-triazine derivatives. Curr Bioact Compd. 16(5), 639-653. ISSN:1875-6646. DOI : 10.2174/1573407215666190308154139
  • Zothantluanga J.H., Lalnunpuii H.S., Bhat H.R., Shakya A. (2019) Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach. Science vision. 19 (4), 120–133. ISSN: 0975-6175(print) https://doi.org/10.33493/scivis.19.04.02
  • Shakya A., Bhat H.R., Ghosh S.K. (2019) Assessment of Neurobehavioral Properties of Hydroalcoholic Extract of Benincasa hispida (Thunb.) Cogn. Fruit Pulp in Mice. Journal of Biologically Active Products from Nature. 2019; 9(4), 299-310. [ISSN: 2231-1866].
  • Shakya, A., Chaudary, S.K., Bhat, H.R., Gogoi, N., Ghosh, S.K. (2019) A Rapid HPTLC Method to Estimate Quercetin in Benincasa hispida (Thunb.) Cogn. Fruit Pulp. Journal of Planar Chromatography. 2019; 32(6), 467-474. [ISSN: 1789-0993; (IF: 0.826).
  • Shakya A., Gogoi N., Chaudhary S.K., Bhat H.R., Ghosh S.K. (2019) Development and Validation of a High-Performance Thin-Layer Chromatography Method for the Quantification of Rutin in the Fruit Pulp of Benincasa hispida (Thunb.) Cogniaux. JPC-J PLANAR CHROMAT. 32 5, 371–377. ISSN: 0933-4173 (IF-0.8)
  • Sahu S., Ghosh S.K., Gahtori P., Singh U.P., Bhattacharyya D.R., Bhat H.R. (2019) In silicoADMET study, Docking, Synthesis and Antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHFR inhibitor. Pharmacology report. DOI: 1016/j.pharep.2019.04.006. ISSN: 1734-1140  (IF-2.787)
  • Das A., Chaudary S.K., Bhat H.R., Shakya A. (2018) cuphea carthagenensis: a review of its ethnobotany, pharmacology and phytochemistry. Bulletin of Arunachal Forest Research, Vol. 33(2), xx-xx: 2018. ISSN (print): 0970-9487.
  • Singh, U.P., Bhat H.R. (2018) Discovery of 1,3,5-triazine-thiazoles (DDTR-502) as potent A2A antagonist/MAO-B inhibitor for the treatment of Parkinson’s disease. Parkinsonism & Related Disorders. 46(2), e39-e40. ISSN: 1353-8020 (IF-4.48) .
  • Shakya A., Bhat H.R., Ghosh S.K. (2017) Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent.Curr Drug Discov Technol.ISSN: 1570-1638. Doi: 10.2174/1570163814666170727130003
  • Kashyap A., Adhikari N., Das A., Shakya A., Ghosh S.K., Singh U.P., Bhat H.R. (2017)Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives.Curr Drug Discov Technol.ISSN: 1570-1638. DOI: 10.2174/1570163814666170911144036
  • Shrivastava J.K., Pillai G.G., Bhat H.R., Verma A.,Singh U.P. (2017) Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase. Nature Sci. Rep. 7: 5851. doi:10.1038/s41598-017-05934-5.  ISSN 2045-2322 (IF-5.22)
  • Singh U.P., Shrivastava J.K., Verma A., Bhat H.R. (2017)Targeting immune and non-immuno synovitis by 1,3,5-TRIAZINE-THIAZOLE via dual inhibition of NF-KB and EGFR-TKS for possible benefit in rheumatoid arthritis. Annals of the Rheumatic Diseases. 76(2) 1072-1073.ISSN:0003-4967 (IF-12.811)
  • Singh U.P., Shrivastava J.K., Verma A., Bhat H.R. (2017)Discovery of 1,3,5-triazine-monastrol based novel EGFR-tyrosine kinase inhibitor against human lung carcinoma.Annals of Oncology. 28(2): ii9-ii13. ISSN:1569-8041 (IF-9.26)
  • Singh UP, Srivastava JK, Bhat HR (2017) Novel monastrol derivatives exert potent anti-breast cancer activity via inhibition of ubiquitin conjugating enzyme Rad6B.European Journal of Cancer.72(1): S36–S37.ISSN: 0959-8049 (IF-6.16).
  • Singh UP, Bhat HR (2017) PUB081 Discovery of 1,3,5-Triazine Based Novel EGFR-Tyrosine Kinase Inhibitor against Human Lung Carcinoma. Journal of Thoracic Oncology.12 (1): S1494–S1495. ISSN: 1556-0864 (IF-5.04).
  • Bhat, HR , Singh, UP,  Yadav, PS,  Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2016) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., 2016; 9: S625-S631. (IF- 3.61) ISSN: 1878-5352
  • Singh UP, Srivastava JK, Bhat HR (2016) Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against Non-small cell lung cancer (NSCLC). Annals of Oncology 27(9):50. (IF- 9.26) ISSN: 1569-8041
  • Sahu S, Ghosh SK, Kalita J, Dutta M, Bhat HR (2016) Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS. Exp Parasitol.163:38-45. (IF- 1.85) ISSN: 1090-2449.
  • Singh UP, Srivastava JK, Bhat HR (2015) Structure-based optimization and discovery of novel 1,3,5-triazine derivatives as bacterial translation inhibitor with favourable metabolic fate. Antimicrob Resist Infect Control., 2015; 4(Suppl 1): I2.
  • Srivastava JK, Awatade NT, Bhat HR, Kmit A, Mendes K, Ramos M, Amaral MD, Singh UP (2015) Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity. RSC Adv., 5, 88710-88718.
  • Bhat HR, Singh UP, Thakur A, Ghosh SK, Gogoi K, Prakash A, Singh RK (2015) Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoquinoline-1,3,5-triazine derivatives. Exp Parasitol.157, 59-67. DOI:10.1016/j.exppara. 2015.06.016 (IF- 1.85)
  • Singh JK, Dubey P, Singh S, Bhat HR, Kumawat MK, Singh UP, (2015) Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 (DPP-4) inhibitor targeting S1 pocket for the treatment of type 2 diabetes along with antibacterial activity. RSC Adv ,5, 14095-14102. (IF- 3.70)
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi K, Prakash A, Singh RK (2015) Synthesis, docking, in vitro and in vivo antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives against wild and mutant malaria parasites, Chemical Biology & Drug Design, DOI: 10.1111/cbdd.12490. (IF- 2.50)
  • Singh B, Bhat HR, Kumawat MK, Singh UP (2014) Structure-guided discovery of 1,3,5-triazine-pyrazole conjugates as antibacterial and antibiofilm agents against pathogens causing human diseases with favourable metabolic fate. Bioorganic & Medicinal Chemistry Letters, 24, 3321-3325, DOI: 10.1016/j.bmcl.2014.05.103 (IF- 2.42)
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi K, Prakash A, Singh RK. (2014). 4-Aminoquinoline-1,3,5-triazine: Design, synthesis, in vitro antimalarial activity and docking studies.ChemInform Abstract, 45, DOI: 10.1002/chin.201404181
  • Pathak P, Thakur A, Bhat HR, Singh UP (2014) Hybrid 4-Aminoquinoline-1,3,5-triazine Derivatives: Design, Synthesis, Characterization, and Antibacterial Evaluation, Journal of Heterocyclic Chemistry, DOI 10.1002/jhet.2210 (IF- 0.78)
  • Singh UP, Bhat HR, Verma A, Kumawat MK, Singh RK (2013) Phenylhydrazone bearing pyrazole and pyrimidine scaffolds: Design and discovery of novel class of Non-nucleoside Reverse Transcriptase Inhibitor (NNRTIs) and antibacterial agent. RSC Adv., 3:17335-17348. DOI: 10.1039/C3RA41604F (IF- 3.70)
  • Singh UP, Bhat HR, Kumawat MK, Singh RK. (2013) Utilisation of Home Laundry Effluent (HLE) as a catalyst for the expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones. SpringerPlus., 2:466. DOI:10.1186/2193-1801-2-466.
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi Kabita, Prakash A, Singh RK. (2013). 4-Aminoquinoline-1,3,5-triazine:Design, synthesis, in vitro antimalarial activity and docking studies. New J. Chem.,37: 2654-2662. DOI: 10.1039/C3NJ00317E.(IF-3.15)
  • Bhat H.R., Kumar P., Ghosh S.K., Singh U.P. (2013) Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route. Med Chem Res., 22:5056-5065. DOI:10.1007/s00044-013-0521-8 (IF-1.62)
  • Kumar S, Bhat HR, Kumawat MK, Singh UP. (2013) Design and one-pot synthesis of hybrid thiazolidin-4-one-1,3,5-triazines as potent antibacterial agent against human disease causing pathogens. New J. Chem., 37:581-584. DOI: 10.1039/C2NJ41028A (IF-3.15)
  • Bhat H.R., Singh U.P., Gahtori P., Ghosh S.K., Gogoi K., Prakash A., Singh R.K. (2013) Antimalarial activity and docking studies of novel bifunctional hybrids derived from 4-aminoquinoline and 1,3,5- triazine against wild and mutant malaria parasites as pf-DHFR inhibitor. RSC Adv., 3:2942-2952. DOI: 10.1039/C2RA21915H (IF- 3.70)
  • Singh UP, Bhat HR, Gahtori P, Singh RK. (2013) Hybrid thiazole-1,3,5-triazines target cytosolic Leucyl-tRNA synthetase for antifungal action revealed by molecular docking studies. In Silico Pharmacology, 1: 3. DOI:10.1186/2193-9616-1-3
  • Singh UP, Bhat HR, Singh RK. (2013) Ceric ammonium nitrate catalysed expeditious one-pot synthesis of 1,3-thiazine as IspE kinase inhibitor of Gram-negative bacteria using polyethylene glycol (PEG-400) as an efficient recyclable reaction medium. C.R.Chim., 16:462-468. DOI: 10.1016/j.crci.2012.11.019 . (IF-1.48)
  • Bhat H.R., Gupta, S.K., Singh U.P. (2012) Discovery of potent, novel antibacterial hybrid conjugates from4-aminoquinoline and 1,3,5-triazine: design, synthesis and antibacterial evaluation. RSC Adv.,2: 12690–12695. DOI: 10.1039/C2RA22353H (IF- 3.70)
  • Dubey V, Pathak M, Bhat HR, Singh UP (2012) Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge.Chem Biol Drug Des., 80(4):598-604. DOI:10.1111/j.1747-0285.2012.01433.x. (IF- 2.50)
  • Singh UP, Pathak M, Dubey V, Bhat HR, Gahtori P, Singh RK. (2012) Design, Synthesis, Antibacterial Activity, and Molecular Docking Studies of Novel Hybrid 1,3-Thiazine-1,3,5-Triazine Derivatives as Potential Bacterial Translation Inhibitor.Chem Biol Drug Des., 80:572-83. DOI:10.1111/j.1747-0285.2012.01430.x (IF- 2.50)
  • Singh, U.P., Bhat, H.R., Gahtori, P. (2012) Antifungalactivity, SAR and physicochemicalcorrelation of some thiazole-1,3,5-triazinederivatives. Journal de Mycologie Médicale. 22:134–141. (IF- 0.4)
  • Gahtori P, Ghosh SK, Parida P, Prakash A, Gogoi K, Bhat HR, Singh UP. (2012) Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: a novel and potential antifolate lead for Pf-DHFR-TS inhibition.Exp Parasitol. 130:292-299.(IF- 1.85)
  • Gahtori, P., Ghosh, S.K., Singh, B., Singh, U.P., Bhat, H.R., Uppal, A., (2012) Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-striazines. Saudi Pharm J., 20:35–43.   (IF- 1.00)
  • Bhat HR, Ghosh SK, Prakash A, Gogoi K, Singh UP. (2012) In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives. Lett Appl Microbiol., 54:483-486. (IF- 1.74)
  • Ghosh, S.k; Saha, A; Hazarika, B; Singh, UP; Bhat, HR; Gahtori, P. (2012) Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di- and Tri-Substituted 1,3,5-Triazines. Letters in Drug Design & Discovery., 9:329-335. (IF- 0.96)
  • Yadav PS, Kumar, V, Singh UP, Bhat, HR, Mazumder B (2012) Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol. Saudi Pharm J.,21:77-84.
  • Bhat, HR, Singh, UP, Yadav, PS, Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2011) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., doi.org/10.1016/j.arabjc.2011.07.001. (IF- 2.68)
  • Singh UP, Singh RK, Bhat HR, Subhashchandra YP, Kumar V, Kumawat MK, et al. (2011) Synthesis and antibacterial evaluation of series of novel tri-substituted-s-triazine derivatives. Med Chem Res., 20:1603-1610. (IF- 1.62)
  • Kumar V, Yadav PS, Singh UP, Bhat HR, Zaman K, Ali M (2011) Isolation of new racemicsugar (D/L galacturonic acid) from leaves of Paederia foetida Linn. Nature Preceedings. DOI: 10.1038/npre.2011.5752.1
  • Kumar V, Yadav PS, Singh UP, Bhat HR, Rana A, Kamaruz ZM (2010)Pharmacognostical evaluation of Cuscuta reflexa Roxb.Phcog J., 2:74-82.
  • Kumar V., Yadav P.S., Singh U.P., Bhatt H.R., Zaman K. (2009) Pharmacognostical and Phytochemical study on Leaves of Peaderia foetida linn. International Journal of PharmTech Research1; 3:918-920.
  • Kumar P., Bhat H.R., DasA. (2008) Synthesis of N-[4'-(4''-substituted Phenyl)-thiazol-2'-yl]-[1,3,5]-triazine-2-amine series as novel antibacterial agents Indian J. Pharm. Sci., 7(2) 107-111. DOI: 10.4103/0250-474X.51960 (IF-0.29)

 

Abstracts Published in Proceedings’:

  • Bhat H.R., Ghosh S.K., Shakya A., Singh U.P., Patgiri S.J. Hybrid pyrazole s-triazine derivatives: Design, synthesis and antimalarial evaluation. Two days International Seminar on Emerging trends in Chemical Science (ETCS-23) at Department of Chemistry, H.V.M. (P.G.) College, Raisi, Haridwar, U.K., March 17, 18, 2023.
  • Dutta S., Choudhary A., Ghosh S.K., Bhat H.R. LDL-C Target in CVS disease is promised by inclisiran. Two days 2nd National Seminar on Novel Innovations in Biomedical Sciences (NIBS)-2023. at Department of Pharmacy, NEMCARE group of institutions, Gauhati, Assam, March 14, 15, 2023. NIBS/23/PP/005
  • Kalita T., Ghosh S.K., Bhat H.R. In silico screening of novel triazine derivatives as possible anti-alzheimer’s agents. Two days 2nd National Seminar on Novel Innovations in Biomedical Sciences (NIBS)-2023. at Department of Pharmacy, NEMCARE group of institutions, Gauhati, Assam, March 14, 15, 2023. NIBS/23/PP/067
  • Bhat H.R., Devanath B., Shakya A., Ghosh S.K., Singh U.P. Design, Synthesis, and In-Vitro Antimalarial Activity Evaluation of Hybrid Pyridine-Pyrazole s-triazine Derivatives. Two days National Seminar on “Integration of Traditional Herbal Medicines of NE India in Clinical Practice: Importance, Challenges and Future" at Department of Pharmaceutical Sciences, Dibrugarh University and RIWATCH, India. November 04-05, 2022.
  • Islama M.A., Bhat HR. “A Systematic Review on Medicinal Plants as Nootropic agents” Two days National Seminar on “Integration of Traditional Herbal Medicines of NE India in Clinical Practice: Importance, Challenges and Future" at Department of Pharmaceutical Sciences, Dibrugarh University and RIWATCH, India. November 04-05, 2022.
  • Choudhary A., Debnath B., Bhat H.R.” Antimalarial drugs derived from plant sources and its current scenerio” Two days National Seminar on “Integration of Traditional Herbal Medicines of NE India in Clinical Practice: Importance, Challenges and Future" at Department of Pharmaceutical Sciences, Dibrugarh University and RIWATCH, India. November 04-05, 2022.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Patgiri S. J. Global Indian Scientists & Technocrats Fest (GIST) (IISF-2021) at Panaji, Goa. Ministry of Earth Sciences, New Delhi, India. December 10-13, 2021 
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Patgiri S. J. Design, synthesis of pyrazole substituted 1,3,5-triazine derivatives as antimalarial. International Virtual Conference on “Advance in chemical Sciences (ACS 2021)” at Harsh PG College, Haridwar, India. December 21-22, 2021.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. in-vitro antimalarial evaluation and synthesis of pyrazole substituted s-triazine derivatives. International Virtual Conference on “Recent Advances in Organic, Medicinal and Biological Chemistry” at Vellore Institute of Technology, Chennai, India. July 8-9, 2020; P-55.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. Design, Synthesis and In-Vitro Antimalarial Evaluation of 1,3,5-triazine derivatives. Young Scientists' Conference (YSC) (IISF-2019) at Kolkata. Ministry of Earth Sciences, New Delhi, India. November 05-07, 2019.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. Design, Synthesis and Antimalarial Evaluation of hybrid dimethoxy pyrazole s-triazine derivatives. National Seminar on ‘Current Research in Drug Discovery and Development’ Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. November 13-14, 2019: P-07.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Bhattacharya D.R. Hybrid 4-Aminoquinoline 1,3,5-triazine: Synthesis and in-vitro Antimalarial Evaluation. National Seminar on ‘Emerging Global Trends in Pharmaceutical Nanotechnology’ Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. November 23-24, 2018: P-07.
  • Bhat H.R., Shakya A., Ghosh S.K., Singh U.P., Kashyap A., Bhattacharya D.R. Design, Synthesis and Antimalarial activity Evaluation of 4-Aminoquinoline s-traizine derivative. Young Scientists' Conference (YSC) (IISF-2018) at Lucknow. Ministry of Earth Sciences, New Delhi, India. October 05-06, 2018.
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antibacterial Evaluation of hybrid 4-aminoquinoline Triazine Derivatives. National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 19.
  • Shakya, A., Bhat, H.R., Ghosh, S.K. A Report on Phytotherapeutic aspect of Benincasa hispida (Thunb.) National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 40
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antibacterial Evaluation of hybrid 4-aminoquinoline Triazine Derivatives. National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 19.
  • Shakya, A., Bhat, H.R., Ghosh, S.K. A Report on Phytotherapeutic aspect of Benincasa hispida (Thunb.) National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 40.
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antimalarial Evaluation of Tri-substituted 1,3,5-Triazine Derivatives. International symposium on contemporary facets in organic synthesis 2017 (CFOS2017) at IIT Roorkee, India. December 22-24, 2017.
  • Shakya, A., Mahanta, S., Bhat, H.R., Ghosh, S.K. Protective effect of the Acmella paniculata against ethanol induced liver and stomach pathologies: a preclinical study. Conference proceedings of 7th Euro-India International Conference on Holistic Medicine (ICHM-2017): Kottayam, Kerala, India. September 15-17, 2017.
  • Shakya, A., Mahanta, S., Bhat, H.R., Ghosh, S.K. Protective effect of the Acmella paniculata against ethanol induced liver and stomach pathologies: a preclinical study. 7th Euro-India International Conference on Holistic Medicine (ICHM-2017): Kottayam, Kerala, India. September 15-17, 2017.
  • Bhat H.R., SinghU.P., Ghosh S.K.Synthesis and antibacterial and antifungal evaluation of Novel 4-Aminoquinoline semicarbazide conjugates.National Conferences onEmerging Trends in Pharmaceutical & Biotechnological Research at Anand college of pharmacy Agra, India, November 06-07, 2015.
  • Singh U.P., Srivastava J.K., Bhat H.R. Discovery of Novel Diaryltriazines (DATAs) as Non-nucleoside Reverse Transcriptase inhibitors via Extension into the Entrance channel of HIV-1 Reverse Transcriptase. international conferences on 15th European Aids Conference, Barcelona, Spain 21-24 October 2015. PE10/1 PP. 180.
  • Verma A., Bhat H.R., Singh U.P., Design and Discovery of potent Hybrid 1,3,5-triazines-1,3-Thiazine Analogs Clubbed via Amide Bridge: A Novel Lead for next generation NNRTI. International conferences on 15th European Aids Conference, Barcelona, Spain 21-24 October 2015. PE10/2 PP. 181.
  • Oral Presentation on the topic of “Design, synthesis and antimalarial activity of Hydrid 4-aminoquinoline 1,3,5-triazine derivatives” International workshop on the topic “Discovery of new drugs against Malaria” at International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi from 27th January to 6th February 2015.
  • Bhat H.R., Singh U.P., Gahtori P., Ghosh S.K., Prakash A., Kavita K., Singh R.K. Hybrid 4-aminoquinoline-1,3,5-triazine derivatives: Design, synthesis, in-vitro antimalarial activity and docking studies against wild & mutant malaria parasites. National conferences on chemistry at the interface of innovative researches in sciences & technology at university of Allahabad. India, Feb 27-28, 2014, P-41, 42.
  • Singh B., Bhat H.R., Kumawat M.K., Singh U.P. Structure-guided synthesis of 1,3,5-triazine–pyrazole conjugates as potent antibacterial and antibiofilm inhibitory activity against pathogens causing human diseases with favorable metabolic fate.National conferences on chemistry at the interface of innovative researches in sciences & technology at university of Allahabad. India, Feb 27-28, 2014, P- 40.
  • Bhat H.R., Singh U.P., Yadav P.K., Ghosh S.K., Prakash A., Mahanta J. Synthesis and Molecular Docking Studies of Hybrid 4-aminoquinoline s-triazines. International Conference on MedChem 2011 at IICT/NIPER Hyderabad. India, Feb 25 and 26, 2011, P-14
  • Singh U.P., Bhat H.R., Pathak M.K., Dubey V., Yadav P.K., Singh R.K., (2011) Molecular Docking Studies of Hybrid 1,3-thiazine-s-1,3,5-triazene Derivatives Against r-RNA: Novel Bacterial Translation Inhibitors. International Conference on MedChem 2011 at IICT/NIPER Hyderabad. India, Feb 25 and 26, 2011, P-12
  • Singh U.P., Bhat H.R., Kumar V., Yadav P. S., Chetia D., Ghosh S. K. “Herpes simplex virus - Antiviral drug resistance” National Conference on Emerging Trends in Pharmaceutical Sciences, Jammu University, Shrinagar, Jammu, 8-9 March 2009.
  • Bhat H.R., Kumar V., Gahtori P., Das A., Chetia D., PrakashA., MahantaJ. Synthesis and Antimalarial activity evaluation of some analogues of 7-chloro-N-[3-(4,6-diamino-1,3,5-triazin-2-ylamino) propyl]quinoline-4-amine derivatives. Antimicrobial Resistance: From Emerging Threat to Reality from 23rd-25th March, 2009, at Allahabad Agricultural Institute-Deemed University, Sponsored by WHO, ICAR, ICMR, DST, NABARD, Govt. of India.
  • Gahtori P., Bhat H.R., Ghosh S.K., Singh B. Antimalarial Drug Resistance need of multiple drug therapy.Antimicrobial Resistance: From Emerging Threat to Reality from 23rd-25th March, 2009, at Allahabad Agricultural Institute-Deemed University, Sponsored by WHO, ICAR, ICMR, DST, NABARD, Govt. of India
  • Kumar V., Bhat H.R., Zaman K. In vitro antioxidant properties of Paederia foetida Linn leaf extract. National Seminar on Recent Advances in Chemical Sciences, Dibrugarh University, Dibrugarh 26-27 March 2009.
  • Kumar V., Bhat H.R., Kumar V. Drugs For Sprotsman. National Seminar On Emerging Trends In Noval Drug Delivery System. H.R. Institute Of Pharmacy, Ghaziabad, 27-28 March 2009.
  • Bhat H.R., Kumar V., Gahtori P., Das A., Chetia D., Prakash A., Mahanta J. Synthesis and Antimalarial activity evaluation of 2, 4, 6-trisubstituted traizine derivative. National Conference on Recent Trends in Pharmaceutical Sciences, Anand college of pharmacy Agra 14-15 November, 2009.
  • Yadav P.S., Kumar V., Singh U.P., Bhat H.R., Ahmed D., Mazumder B. Physicochemical characterisation and in-vitro dissolution studies of solid dispersion of Ketoprofen with PVP K30 and D-Mannitol. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Kumar V., Yadav P.S., Singh U.P., Bhat H.R., Ahmed D. Review: Method for Evaluation of in-vitro and in-vivo Antioxidant Activity. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Ahmed D., Singh U.P., Kumar V., Yadav P.S., Bhat H.R., Effect of Rosiglitazone, Atorvastatin and Glimipride on Glycemic control and Lipid Profile on STZ induced NIDDM rats. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Kaithwas G., Singh U.P., Yadav P.S., Kumar V., Bhat H.R., Ahmed D. Diagnosis of Filarial Parasites. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Bhat H.R., Singh U.P., Yadav P.S., Kumar V., Gahtori P., Das A., Chetia D., Prakash A., Mahanta J. Synthesis and Antimalarial activity evaluation of some analogues of 7-chloro-N-[3-(4,6-diamino-1,3,5-triazin-2-ylamino) propyl] quinoline-4-amine derivatives. (Accepted for poster presentation,4th international Symposium on Current trends in drug discovery research Lucknow 17-21 Feb. 2010)
  • Singh U.P., Bhat H.R., Yadav P.S., Kumar V, Kumawat M.K., Gahtori P. synthesis and antibacterical evaluation of series of noval tri-substituted s-triazine derivatives. (Accepted for poster presentation, 4th international Symposium on Current trends in drug discovery research Lucknow 17-21 Feb. 2010)

·          Singh UP, Srivastava JK, Bhat HR (2016) Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against Non-small cell lung cancer (NSCLC). Annals of Oncology 27(9):50. (IF- 9.26) ISSN: 1569-8041

·          Bhat, HR , Singh, UP,  Yadav, PS,  Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2016) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., 2016; 9: S625-S631. (IF- 3.61) ISSN: 1878-5352

·          Sahu S, Ghosh SK, Kalita J, Dutta M, Bhat HR (2016) Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS. Exp Parasitol.163:38-45. (IF- 1.85) ISSN: 1090-2449.

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