Dr. A. Das

Professor, Department of Pharmaceutical Sciences

Profile

Education:

  1. Bachelor’s Degree : B.Pharm (Dibrugarh University)
  2. Master’s Degree : M.Pharm (Birla Institute of Technology, Mesra, Ranchi)
  3. Ph.D.: Pharmaceutical Sciences (Dibrugarh University)
  4. Other: PDCR (Catalyst Clinical Services, New Delhi), Post Doc (USF-Health)

Professional Experience:

  • 24 Years in Teaching & Research

Areas of Interest/ Specialization:

  • Medicinal Chemistry/ Drug Discovery and Development

Research Projects:

Projects Completed as PI:

  1. AICTE funded RPS Project entitled “Phytochemical and Pharmacological Screening of the fruits of Garcinia cowa with special reference to Antidiarrhoeal activity”. (PI)

Projects Completed as Co-PI:

  1. Synthesis of hybrid class phenylthiazole 1,3,5-triazine derivatives as novel antimalarial for Pf-DHFR-TS inhibition.

Research Project Ongoing:

  • AICTE funded RPS-NER Project entitled “Design, synthesis and characterization of topoisomerase II alpha xanthone inhibitors and their chemotherapeutic polymeric nano carriers for the treatment of colorectal cancer”. (PI)

Research Project Completed as Mentor:

  • ICMR RA Project entitled “Isolation and characterization of the active principles of leaves of Annona reticulate Linn. And their encapsulation into polymeric nanostructured drug delivery system for the treatment of Diabetes” (Mentor)

Research Project Ongoing as Mentor:

  • Design, Synthesis and Evaluation of hybrid xanthone derivatives as potential anti-cancer agents. (UGC National Fellowship) (Mentor)

Ph.D Scholars:

SL No.

Name of the Scholars registered

Subject

Research Topic

Date of Registration

Status

1

Kalyani Pathak

Pharmaceutical Sciences

Isolation and Characterization of Bioactive molecule(s) of the Leaves of Annona reticulata Linn., a folklore herbal drug of Assam

29.09.2014

Awarded

01.11.2019

2

Ejiofor InnocentMary IfedibaluChukwu

Pharmaceutical Sciences

Phytochemical and Pharmacological Investigations of

Vernonia amygdalina- A Traditional Medicinal Plant of Nigeria.

07.10.2015

Awarded

01.07.2019

3

Manash Pratim Pathak

Pharmaceutical Sciences

Pharmacological intervention of Airway
Hyperresponsiveness in obese murine model"

07.10.2015

Awarded

01.04.2021

4

Shyamalendu Nath

Pharmaceutical Sciences

Mining of Biologically

Active Molecules from Some Plants Belonging to the Genus Caesalpinia

and Elsholtzia from Jorhat and Dibrugarh Districts of Assam.

07.10.2015

Awarded

01.05.2022

5

Urvashee Gogoi

Pharmaceutical Sciences

Design, Synthesis and Evaluation of Hybrid Xanthone Derivatives as Potential Anti-Cancer Agents.

28.02.2018

On-going

6

Ankita Khataniar

Biotechnology and Bioinformatics

Isolation, Characterization and Bioactivity Evaluation of Schefflera venulosa (Wight & Arn.) Harms, A Traditional Medicine of North East India

12.09.2019

On-going

7

Riya Saikia

Pharmaceutical Sciences

In Silico Design, synthesis and Evaluation of Hydroxyxanthone Derivatives As Potential Anti-Diabetic Agents

24.09.2020

On-going

8

Pinku Gogoi

Pharmaceutical Sciences

Exploration of Phytochemicals of Dillenia indica L. and Ipomoea aquatica FORSSK. For Development of Potential Anti-Diabetic and Anti-Obesity Compounds

24.09.2020

On-going

9

Jon Jyoti Sahariah

Pharmaceutical Sciences

Design, Synthesis and Evaluation of Anti-cancer activity of some Hybrid Benzoxanthone Derivatives

07.03.2022

On-going

Administrative Assignment:

  • Chairperson, Center for Biotechnology and Bioinformatics, DU

Extension Service:

  • Associated with various Professional bodies

Membership:

  • Life Member Indian Pharmaceutical Association.
  • Life Member InPharm Association.

Publications

List of Publications:

  1. Pathak K, Das RJ, Saika R, Sahariah JJ, Pathak H, Sarma H and Das A. Design and fabrication of gallic acid loaded chitosan nanoformulation. Drug Deliv. Lett.2022; DOI:10.2174/2210303112666220512154520. (IF. 0.606)
  1. Gogoi N, Chowdhury P, Goswami AK, Das A, Chetia D, Gogoi B. Integrated computational approach towards repurposing of antimalarial drug against SARS-CoV-2 main protease. Struct Chem. 2022 May 27; 1-14. https://doi.org/10.1007/s11224-022-01916-0(IF. 1.887)
  1. Pathak M P, Pathak K , Saikia R , Gogoi U, Ahmad Md Z, Patowary P and Das A, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomed Pharmacother , 149 (2022) 112901, https://doi.org/10.1016/j.biopha.2022.112901(IF. 6.592)
  1. Pathak K, Pathak MP, Saikia R, Gogoi U, Sahariah J J, Zothantluanga H J, Samanta A and Das A, Cancer Chemotherapy via Natural Bioactive Compounds, Curr Drug Discov Technol, 2022;19(2): e310322202888 . https://dx.doi.org/10.2174/1570163819666220331095744(IF. 1.72)
  2. Pathak K, Das R J, Gogoi N, Saikia R, Sarma H and Das A,. Validated High-Performance Thin Layer Chromatography method for simultaneous determination of Quercetin and Gallic acid in Annona reticulata, Journal of Planar Chromatography - Modern TLC. February 2022, https://doi.org/10.1007/s00764-022-00151-x(IF. 0.75)
  1. Nath S, Tamuli K, Saikia S, Narzary B, Gogoi B, Lhouvum N, Dutta D, Sahoo R, Bordoloi M. Das A, Barua I. Essential Oil from the Leaves of Elsholtzia Communis (Collett & Hemsl.) Diels from North East India: Studies on Chemical Profiling, Antimicrobial, Cytotoxic and ACE Inihibitory Activities. Flavour Fragr J. 2021; 36 (6): 626-636. ISSN: 1099-1026(Online) https://doi.org/10.1002/ffj.3677(IF. 2.576)
  1. Gogoi N, Chowdhury P, Goswami AK, Das A, Chetia D, Gogoi B. Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease. Molecular diversity. 2021, 25 (3), 1745-1759 (IF. 2.934)
  1. Pathak K, Das A, Das R.J. and Sarma H.Evaluation of leaf fraction of Annona reticulata for antioxidant activity and anti-inflammatory potential against Carrageenan induced rat paw edema model. Indian Journal of Natural Sciences.2021, 12(68):33877-33888.
  1. Sandilya S, Das A, Deka S, Kalita R. Synthesis, in-vivo anti-inflammatory evaluation and molecular Docking study of a series of substituted xanthone derivatives as novel Cox-2 inhibitors., Int J Pharm Sci Res. 2021; Vol. 12(8): 4491-4503., DOI: 10.13040/IJPSR.0975-8232.12(8).4491-03
  1. Pathak K, Das RJ. Saikia R, Das A, Ahmad MZ. Bora Rice: Natural polymer for drug delivery, Mater. Proc. 2021; 7, 2. https//doi.org/10.3390/IOCPS2021-11290.
  1. Gogoi U, Das A, Pathak MP, Chattopadhyay P, Johari S. Design, Synthesis, Computational and Biological Evaluation of two new series of 1, 3-and 1,6-dihydroxyxanthone derivatives as selective COX-2 inhibitors. Lett Drug Des Discov.2021; 18(9):884-914.
  1. Pathak MP, Patowary P, Das A, Goyary D, Karmakar S, Bhutia YD, Roy P, Das S, Chattopadhyay P. Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by β-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. Clinical and Experimental Pharmacology and Physiology.2021; org/10.1111/1440-1681.13555(IF. 2.372)
  1. Pathak MP, Patowary P, Goyary D, Das A, Chattopadhyay P. β- caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets. Phytomedicine.153610.doi.org/10.1016/j.phymed.2021.153610. (IF. 5.34)
  1. Nath S, Tamuli KJ,Gogoi B, Bordoloi M, Das A, Barua CC, Barua IC. Antioxidant properties, phenolic and mineral profiling, assessment of angiotensin I converting enzyme (ACE) inhibitory potential of Elsholtzia communis (Collett & Hemsl.) Diels from North East India. Eur J Integr Med. 2020.Vol: 40.ISSN: 1876-3820(Print). https://doi.org/10.1016/j.eujim.2020.101247(IF. 1.314)
  1. Ejiofor II, Das A, Kamaruz Z. Antidiabetic, anthelmintic and antioxidation properties of novel and new phytocompounds isolated from the methanolic stem-bark of Vernonia amygdalina Delile (Asteraceae). Sci Afr. 2020; 10:e00578. DOI:https://doi.org/10.1016/j.sciaf.2020.e00578.
  2. Gogoi N, Chetia D, Gogoi B, Das A. Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In Silico and Whole Cell-based In vitro Curr Comput Aided Drug Des.2020;16:DOI: 10.2174/1573409916666191226103000. (IF. 1.606)
  3. Baruah, V J, Paul R, Gogoi D, Mazumder N, Chakraborty S, Das A, Mondal TK, Sarmah B. Integrated computational approach toward discovery of multi-targeted natural products from Thumbai (Leucas aspera) for attuning NKT cells.J Biomol Struct Dyn, 2020; 1-15. (Online version; Impact factor:3.310; doi: 10.1080/07391102.2020.1844056). (IF. 3.392)
  4. Pathak K, Das A, Shakya A, Saikia R, Sarma H. Evaluation of Anti-diabetic and Anti-hyperlipidemic activity of isolated bioactive compounds of leaves of Annona reticulata J. Nat. Prod. 2020; 10:1-8. DOI:10.2174/2210315510999200511132940.
  5. Pathak MP, Das A, Patowary P, Chattopadhyay P. Continuous role of ‘Good Adiponectin’ in pulmonary and cardiovascular diseases: Is adiponectin directed therapy a boon or a bane? Biochimie. 2020; 175:1-14. (IF. 4.079)
  6. Ejiofor II, Das A, Mir SR, Ali M, Zaman K. Novel phytocompounds from Vernonia amygdalina with antimalarial potentials. Phcog Res. 2020; 12(1):53-59.
  7. Saikia R, Gogoi P, Hore D, Kumar S, Das A. Synthesis and in-vitro evaluation of anti-cancer potential of new hydroxyl derivatives of xanthone. Current Trends in Pharmaceutical Research. 2019; 6(1):105-135.
  8. DasA, Shakya A, Ghosh SK, Singh UP, Bhatt HR. A Review of Phytochemical and Pharmacological Studies of Inula Species. Curr Bioact Compd. 2019; 16(5):557-567.
  9. Pathak K, Saikia R, Gogoi U, Das A. Untapped potential of the indigenous anticancer biodiversity in the Indo-Himalayan hotspot. J. Pharmacogn. 2019; 6(3):85-98.
  10. Johari S, Sharma A, Sinha S, Das A. Integrating pharmacophore mapping, virtual screening, density functional theory, molecular simulation towards the discovery of novel apolipoprotein (apoE ε4) inhibitors. Comput Biol Chem. 2019 Apr; 79:83-90. (IF. 2.877)
  11. Borah T,Gogoi B, Khataniar A, Gogoi M, Das A,Borah D. Probiotic characterization of indigenous Bacillus velezensis strain DU14 isolated from Apong, a traditionally fermented rice beer of Assam. Biocatal Agric Biotechnol. 2019 Jan; 18:101008. https://doi.org/10.1016/j.bcab.2019.01.046(IF. 3.281)
  12. Pathak K, Das A. Anti-inflammatory study of Leaf extracts of Annona reticulata Linn and HPTLC analysis. Int J Pharma Bio Sci. 2019 Jan; 10(1):68-77.
  13. Pathak K, Das A. Assessment of Anti-oxidant activity of different extracts of Annona reticulata Int J Pharm Sci Res. 2018; 9(6):1000-1008.
  14. Pathak MP, Policegoudra RS, Goyary D, DasA, Mandal S, Chakraborti S, Bora NS, Islam J, Patowary P, Raju PS, Chattopadhyay P. Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays. Drug Chem Toxicol. 2018 Apr; 41(2):147-154.
  15. Pathak K, Das A. Anti-hyperglycemic activity of Leaves of Annona reticulata Linn on Experimental Rat Diabetic Model. European Biomed. Pharm. 2017 Mar; 4(11):674-677.
  16. Ejiofor II, Zaman K, Das A. Effect of Extracts of Vernonia Amygdalina in Helminthiasis-A Tropical Neglected Disease. Pharm Res2017 Dec; 1(8):000147.
  17. Ejiofor II, Zaman K, Das A. Antidiabetic Evaluations of Different Parts of Vernonia Amygdalina. IOSR J Pharm Biol Sci. 2017 Aug; 12(4): 23-28.
  18. Tur J, Badole SD, Cheng F, Das A, Kukreja RC, Tipparaju SM. Corticosteroids and aldose reductase inhibitor Epalrestat modulates cardiac action potential via Kvβ1.1(AKR6A8) subunit of voltage gated potassium channel. Mol Cell Biochem. 2017 Dec; 436(1-2):71-78. (IF. 3.396)
  19. Bhatt HR, Singh UP, Yadav PS, Kumar V, Gahtori P, DasA, Chetia D, Prakash A, Mahanta J. Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine Arab J Chem. 2016; 9:S625-S631.(IF. 5.165)
  20. Bairy PS, Bora NS, Kakoti BB, DasA, Nainwal LM, Gogoi B. Preliminary phytochemical screening, in-vitro antioxidant activity, total polyphenolic and flavonoid content of Garcinia lanceifolia and Citrus maxima (Burm.) Merr. J App Pharm Sci. 2016; 6(9):133-139.
  21. Gahtori P, Pandey R, Kumar V, Ghosh SK, Das A, Kalita JM, Sahu S, Prakash A, Bhattacharyya DR. Toward resistance-compromised DHFR inhibitors part 1: Combined structure/ligand-based virtual screenings and ADME-Tox profiling. J Chemom. 2016 Aug; 30(8):1-20.
  22. Das A,Gogoi U, Kalita J, Sandilya Molecular Docking Study of a Series of Substituted Xanthone Derivatives as Novel COX-2 Inhibitors Targeting Prostaglandin Endoperoxide Synthase -2. Curr Enzym Inhib. 2016; 12(2):195-204.
  23. Das A, Dutta M, Malakar M. In-silico study, synthesis and biological evaluation of some substituted xanthone derivatives as alpha-glucosidase inhibitor. World J Pharm Sci. 2016 Mar; 4(4): 150-161.
  24. Bairy PS, Das A, Nainwal LM, Mahanta TK, Kumawat MK, Mohapatra PK, Parida P. Design, synthesis and anti-diabetic activity of some novel xanthone derivatives targeting α-glucosidase. Bangladesh J Pharmacol. 2016; 11:308-318.
  25. Bairy PS, Shankar B. Das A. Diabetes mellitus and antidiabetics with reference to Alpha Glucosidase Inhibitors. Asian J Biomed Pharm. 2015; 4(6):10-16.
  26. Shankar B, Das A, Parida P. Design, Molecular Docking Study and Synthesis of 3,6-bis(3′-substituted propoxy)xanthone Derivatives as COX-2 Inhibitors. Asian J. Chem. 2015; 27(12):4634-4640.
  27. Nainwal LM, Parida P, Das A, Bairy PS. Design and docking of novel series of hybrid xanthones as anti-cancer agent to target human DNA topoisomerase 2-alpha. Bangladesh J Pharmacol. 2014; 9:208-217.
  28. Parida P, Kalita S, Shankar B, Yadav RNS, Das A. Homology modelling and docking studies of Plasmodium falciparum telomerase reverse transcriptase with berberine and some of its derivatives. Bangladesh J Pharmacol. 2014; 9:96-104.
  29. Das A, Shaikh M, Jana S. Design, synthesis and in vitro antibacterial screening of some novel 3-pentyloxy-1-hydroxyxanthone Derivatives. Med Chem Res. 2014; 23:436-444.
  30. Bairy PS, Das A, Nainwal LM, Shrivastava M. Preliminary Phytochemical Investigation and Anti-inflammatory Activity Studies of Christella arida leaf extract. Proceedings of International conference cum exhibition on Drug Discovery and Development from Natural Resources. 2014; Feb: 126-133.
  31. Das A, Debnath K, Bairy PS, Nainwal LM. Synthesis and antimicrobial screening of a series of 3,6 bis(3’substituted propoxy) and 3,6 bis (5’substitutedpentyloxy) xanthone derivatives. Current Trends in Pharmaceutical Research. 2013; 2(1):13-23.
  32. Boruah L, DasA, Nainwal LM, Agarwal N, Shankar B. In-Silico Drug Design: A revolutionary approach to change the concept of current Drug Discovery Process. Indian J. Pharm. Biol. Res. 2013; June;1(1):60-73.
  33. Das A, Parida P, Agarwal N, Shree J, Shankar B, Chakraborty D. Molecular docking study of 3,6 bis(3’substituted propoxy) and 3,6 bis (5’substitutedpentyloxy) xanthone derivatives as PGHS- 2 inhibitors. J. Appl. Pharm. Sci. 2013 May; 3(4 Suppl.1):S13-S22.
  34. Parida P, Yadav RNS, Shankar B, Chakraborty D, Das A, Singh NK. In-silico protein ligand interaction study of typical antipsychotic drugs against dopaminergic D2 receptor. J. Pharm. Pharm. Sci. 2013; 5(2):183-189.
  35. Jana S, Das Synthesis and Assessment of Antibacterial Activity of some Novel 4-Benzyl-piperazinyl-s-triazine Derivatives. Asian J. Chem. 2013; 25(1):186-190.
  36. Singh RB, Das N, Jana S, Das A. Synthesis and In Vitro Antibacterial Screening of some New 2,4,6 Trisubstituted-1,3,5- Triazine Lett Drug Des Discov. 2012; 9:316-321.
  37. Gahtori P, DasA, Mishra R. Design, Synthesis and Antibacterial Activity of Substituted Phenyl Thiazolyl s-Triazines. Chem. J. 2011 Jul; 45(4):248-252.
  38. Kaushik A, Kaushik JJ, DasA, Gemal S, Gaim D. Preliminary studies on anti-inflammatory activities of Diplazium esculentum in experimental animal models. J. Pharm. Sci. 2011 Apr; 2(5):1251-1253.
  39. Gahtori P, Singh A, Ghosh SK, Das A, Archana U. Synthesis of some substituted Phenythiazolyl 1,3,5-Triazine derivatives. Asian J. Chem. 2011; 23(3):1189-1192.
  40. Singh UP, Das A, Chetia D, Bhattacharya A, Subhaschandra YPK, Kumar V, Bhatt HR, Synthesis and Antibacterial Activity of Some 2,4,6-trisubstituted-1,3,5-triazines. Lat Am J. Pharm. 2010; 29(4):607-611.
  1. Gahtori P, Das A, Bhatt HR. Synthesis and antibacterial assessment of N-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine. Indian J Pharm Sci. 2009 Feb; 71(1):79-82.
  2. Das A, Kaushik A, Jyoti J, Veerma R. Anti-inflammatory activities of Cleome isocandra seed oil in experimental animal models. J. Phytochem. Ayurvedic Heights. 2006 Apr; 2(1):11-13.
  1. Akhtar N, Ali M, Das A. Antibacterial Activity of Inula cuspidate Indian journal Nat. Prod. 2006; 22 (3):33-34.
  2. Kaushik A, Kaushik JJ, DasA, Saini V. Antimycotic effects of essential oil of leaves of Artemesia nilagirica Linn. Indian Perfumer. 2005 Oct; 49(4): 515-517.

Book Chapters:

  1. Das A, Pathak, MP, Chattopadhyay P and Pathak YV. Gene-Based Dietary Advice and Eating Behavior. In: YV Pathak & AM Ardekani (eds), Nutrigenomics and Nutraceuticals: Clinical Relevance and Disease Prevention, 1st Edition, CRC Press. 2017;(515-528).DOI:https://doi.org/10.1201/9781315153711
  1. Das A, Pathak K, Pathak MP, Chattopadhyay P, Saikia R, Sahu S and Gogoi U. Enzyme Inhibition. In: C. Singhla (ed), Recent Advances in Pharmaceutical Sciences., Akinik Publications, New Delhi. 2020; (01-37): ISBN: 978-93-90217-69-4., DOI: https://doi.org/10.22271/ed.book.795
  1. Das A, Saikia R, Pathak K, Gogoi U and Pathak MP. Anti-diabetic Nano-formulation from Herbal Source. In: MK Das & Y Pathak (eds), Nano Medicine and Nano Safety: Recent Trends and Clinical Evidences., Springer, Singapore. 2020; (61-84). Print ISBN 978-981-15-6254-9., DOI: 10.1007/978-981-15-6255-6_4
  1. Pathak K, Pathak MP, Gogoi U, Saikia R and Das A. COVID19: Preventive and Protective Control Management Strategies. Coronaviruses, Bentham Science Publishers Pte. Ltd. Singapore. 2021; Vol. 2: 32-62. ISBN (Print): 978-981-4998-61-1
  1. Das A, Pathak MP, Patowary P, Das S. Introduction to Lung Physiology from a Drug Delivery Perspective. In: Y Pathak & N Islam (eds), Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences. 1st Edition, CRC Press. 2021;(1-11) DOI: https://doi.org/10.1201/9781003046547
  1. Das A, Saikia R, Pathak K, Gogoi U, Saikia S. Chronic Lung Diseases: Treatment, Challenges, and Solutions. In: Pathak Y & Islam N (eds), Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences. 1st Edition, CRC Press. 2021;(57-68) DOI: https://doi.org/10.1201/9781003046547
  1. Saikia S, Das A, Pathak Y. Drug Delivery Using Aerosols: Challenges and Advances in Neonatal Pediatric Subgroup. In: Y Pathak & N Islam (eds), Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences. 1st Edition, CRC Press. 2021; (623-629).DOI: https://doi.org/10.1201/9781003046547
  2. Pathak K, Gogoi U, Pathak MP, Saikia R, Das A. Modified Marine Antidiabetics: An insight into their sources, chemistry, SAR and molecular mechanisms. In: Rahman-Atta-ur(ed), Natural Product Chemistry (Bioactive Natural Products) Elsevier Science.2022 May 27, 1st Edition, Hardcover ISBN: 9780323910972
  3. Saikia S, Das A, Pathak Y. Gold Nanoparticles in Cancer Theranostics. In: Y Pathak & L Kumar (eds), Nanocarriers for Drug- Targeting Brain Tumors. 1st Edition, Elsevier.2022; June 17; Paperback ISBN: 9780323907736.
Profile

Profile

Education:

  1. Bachelor’s Degree : B.Pharm (Dibrugarh University)
  2. Master’s Degree : M.Pharm (Birla Institute of Technology, Mesra, Ranchi)
  3. Ph.D.: Pharmaceutical Sciences (Dibrugarh University)
  4. Other: PDCR (Catalyst Clinical Services, New Delhi), Post Doc (USF-Health)

Professional Experience:

  • 24 Years in Teaching & Research

Areas of Interest/ Specialization:

  • Medicinal Chemistry/ Drug Discovery and Development

Research Projects:

Projects Completed as PI:

  1. AICTE funded RPS Project entitled “Phytochemical and Pharmacological Screening of the fruits of Garcinia cowa with special reference to Antidiarrhoeal activity”. (PI)

Projects Completed as Co-PI:

  1. Synthesis of hybrid class phenylthiazole 1,3,5-triazine derivatives as novel antimalarial for Pf-DHFR-TS inhibition.

Research Project Ongoing:

  • AICTE funded RPS-NER Project entitled “Design, synthesis and characterization of topoisomerase II alpha xanthone inhibitors and their chemotherapeutic polymeric nano carriers for the treatment of colorectal cancer”. (PI)

Research Project Completed as Mentor:

  • ICMR RA Project entitled “Isolation and characterization of the active principles of leaves of Annona reticulate Linn. And their encapsulation into polymeric nanostructured drug delivery system for the treatment of Diabetes” (Mentor)

Research Project Ongoing as Mentor:

  • Design, Synthesis and Evaluation of hybrid xanthone derivatives as potential anti-cancer agents. (UGC National Fellowship) (Mentor)

Ph.D Scholars:

SL No.

Name of the Scholars registered

Subject

Research Topic

Date of Registration

Status

1

Kalyani Pathak

Pharmaceutical Sciences

Isolation and Characterization of Bioactive molecule(s) of the Leaves of Annona reticulata Linn., a folklore herbal drug of Assam

29.09.2014

Awarded

01.11.2019

2

Ejiofor InnocentMary IfedibaluChukwu

Pharmaceutical Sciences

Phytochemical and Pharmacological Investigations of

Vernonia amygdalina- A Traditional Medicinal Plant of Nigeria.

07.10.2015

Awarded

01.07.2019

3

Manash Pratim Pathak

Pharmaceutical Sciences

Pharmacological intervention of Airway
Hyperresponsiveness in obese murine model"

07.10.2015

Awarded

01.04.2021

4

Shyamalendu Nath

Pharmaceutical Sciences

Mining of Biologically

Active Molecules from Some Plants Belonging to the Genus Caesalpinia

and Elsholtzia from Jorhat and Dibrugarh Districts of Assam.

07.10.2015

Awarded

01.05.2022

5

Urvashee Gogoi

Pharmaceutical Sciences

Design, Synthesis and Evaluation of Hybrid Xanthone Derivatives as Potential Anti-Cancer Agents.

28.02.2018

On-going

6

Ankita Khataniar

Biotechnology and Bioinformatics

Isolation, Characterization and Bioactivity Evaluation of Schefflera venulosa (Wight & Arn.) Harms, A Traditional Medicine of North East India

12.09.2019

On-going

7

Riya Saikia

Pharmaceutical Sciences

In Silico Design, synthesis and Evaluation of Hydroxyxanthone Derivatives As Potential Anti-Diabetic Agents

24.09.2020

On-going

8

Pinku Gogoi

Pharmaceutical Sciences

Exploration of Phytochemicals of Dillenia indica L. and Ipomoea aquatica FORSSK. For Development of Potential Anti-Diabetic and Anti-Obesity Compounds

24.09.2020

On-going

9

Jon Jyoti Sahariah

Pharmaceutical Sciences

Design, Synthesis and Evaluation of Anti-cancer activity of some Hybrid Benzoxanthone Derivatives

07.03.2022

On-going

Administrative Assignment:

  • Chairperson, Center for Biotechnology and Bioinformatics, DU

Extension Service:

  • Associated with various Professional bodies

Membership:

  • Life Member Indian Pharmaceutical Association.
  • Life Member InPharm Association.
Publications

Publications

 

List of Publications:

  1. Pathak K, Das RJ, Saika R, Sahariah JJ, Pathak H, Sarma H and Das A. Design and fabrication of gallic acid loaded chitosan nanoformulation. Drug Deliv. Lett.2022; DOI:10.2174/2210303112666220512154520. (IF. 0.606)
  1. Gogoi N, Chowdhury P, Goswami AK, Das A, Chetia D, Gogoi B. Integrated computational approach towards repurposing of antimalarial drug against SARS-CoV-2 main protease. Struct Chem. 2022 May 27; 1-14. https://doi.org/10.1007/s11224-022-01916-0(IF. 1.887)
  1. Pathak M P, Pathak K , Saikia R , Gogoi U, Ahmad Md Z, Patowary P and Das A, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomed Pharmacother , 149 (2022) 112901, https://doi.org/10.1016/j.biopha.2022.112901(IF. 6.592)
  1. Pathak K, Pathak MP, Saikia R, Gogoi U, Sahariah J J, Zothantluanga H J, Samanta A and Das A, Cancer Chemotherapy via Natural Bioactive Compounds, Curr Drug Discov Technol, 2022;19(2): e310322202888 . https://dx.doi.org/10.2174/1570163819666220331095744(IF. 1.72)
  2. Pathak K, Das R J, Gogoi N, Saikia R, Sarma H and Das A,. Validated High-Performance Thin Layer Chromatography method for simultaneous determination of Quercetin and Gallic acid in Annona reticulata, Journal of Planar Chromatography - Modern TLC. February 2022, https://doi.org/10.1007/s00764-022-00151-x(IF. 0.75)
  1. Nath S, Tamuli K, Saikia S, Narzary B, Gogoi B, Lhouvum N, Dutta D, Sahoo R, Bordoloi M. Das A, Barua I. Essential Oil from the Leaves of Elsholtzia Communis (Collett & Hemsl.) Diels from North East India: Studies on Chemical Profiling, Antimicrobial, Cytotoxic and ACE Inihibitory Activities. Flavour Fragr J. 2021; 36 (6): 626-636. ISSN: 1099-1026(Online) https://doi.org/10.1002/ffj.3677(IF. 2.576)
  1. Gogoi N, Chowdhury P, Goswami AK, Das A, Chetia D, Gogoi B. Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease. Molecular diversity. 2021, 25 (3), 1745-1759 (IF. 2.934)
  1. Pathak K, Das A, Das R.J. and Sarma H.Evaluation of leaf fraction of Annona reticulata for antioxidant activity and anti-inflammatory potential against Carrageenan induced rat paw edema model. Indian Journal of Natural Sciences.2021, 12(68):33877-33888.
  1. Sandilya S, Das A, Deka S, Kalita R. Synthesis, in-vivo anti-inflammatory evaluation and molecular Docking study of a series of substituted xanthone derivatives as novel Cox-2 inhibitors., Int J Pharm Sci Res. 2021; Vol. 12(8): 4491-4503., DOI: 10.13040/IJPSR.0975-8232.12(8).4491-03
  1. Pathak K, Das RJ. Saikia R, Das A, Ahmad MZ. Bora Rice: Natural polymer for drug delivery, Mater. Proc. 2021; 7, 2. https//doi.org/10.3390/IOCPS2021-11290.
  1. Gogoi U, Das A, Pathak MP, Chattopadhyay P, Johari S. Design, Synthesis, Computational and Biological Evaluation of two new series of 1, 3-and 1,6-dihydroxyxanthone derivatives as selective COX-2 inhibitors. Lett Drug Des Discov.2021; 18(9):884-914.
  1. Pathak MP, Patowary P, Das A, Goyary D, Karmakar S, Bhutia YD, Roy P, Das S, Chattopadhyay P. Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by β-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. Clinical and Experimental Pharmacology and Physiology.2021; org/10.1111/1440-1681.13555(IF. 2.372)
  1. Pathak MP, Patowary P, Goyary D, Das A, Chattopadhyay P. β- caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets. Phytomedicine.153610.doi.org/10.1016/j.phymed.2021.153610. (IF. 5.34)
  1. Nath S, Tamuli KJ,Gogoi B, Bordoloi M, Das A, Barua CC, Barua IC. Antioxidant properties, phenolic and mineral profiling, assessment of angiotensin I converting enzyme (ACE) inhibitory potential of Elsholtzia communis (Collett & Hemsl.) Diels from North East India. Eur J Integr Med. 2020.Vol: 40.ISSN: 1876-3820(Print). https://doi.org/10.1016/j.eujim.2020.101247(IF. 1.314)
  1. Ejiofor II, Das A, Kamaruz Z. Antidiabetic, anthelmintic and antioxidation properties of novel and new phytocompounds isolated from the methanolic stem-bark of Vernonia amygdalina Delile (Asteraceae). Sci Afr. 2020; 10:e00578. DOI:https://doi.org/10.1016/j.sciaf.2020.e00578.
  2. Gogoi N, Chetia D, Gogoi B, Das A. Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In Silico and Whole Cell-based In vitro Curr Comput Aided Drug Des.2020;16:DOI: 10.2174/1573409916666191226103000. (IF. 1.606)
  3. Baruah, V J, Paul R, Gogoi D, Mazumder N, Chakraborty S, Das A, Mondal TK, Sarmah B. Integrated computational approach toward discovery of multi-targeted natural products from Thumbai (Leucas aspera) for attuning NKT cells.J Biomol Struct Dyn, 2020; 1-15. (Online version; Impact factor:3.310; doi: 10.1080/07391102.2020.1844056). (IF. 3.392)
  4. Pathak K, Das A, Shakya A, Saikia R, Sarma H. Evaluation of Anti-diabetic and Anti-hyperlipidemic activity of isolated bioactive compounds of leaves of Annona reticulata J. Nat. Prod. 2020; 10:1-8. DOI:10.2174/2210315510999200511132940.
  5. Pathak MP, Das A, Patowary P, Chattopadhyay P. Continuous role of ‘Good Adiponectin’ in pulmonary and cardiovascular diseases: Is adiponectin directed therapy a boon or a bane? Biochimie. 2020; 175:1-14. (IF. 4.079)
  6. Ejiofor II, Das A, Mir SR, Ali M, Zaman K. Novel phytocompounds from Vernonia amygdalina with antimalarial potentials. Phcog Res. 2020; 12(1):53-59.
  7. Saikia R, Gogoi P, Hore D, Kumar S, Das A. Synthesis and in-vitro evaluation of anti-cancer potential of new hydroxyl derivatives of xanthone. Current Trends in Pharmaceutical Research. 2019; 6(1):105-135.
  8. DasA, Shakya A, Ghosh SK, Singh UP, Bhatt HR. A Review of Phytochemical and Pharmacological Studies of Inula Species. Curr Bioact Compd. 2019; 16(5):557-567.
  9. Pathak K, Saikia R, Gogoi U, Das A. Untapped potential of the indigenous anticancer biodiversity in the Indo-Himalayan hotspot. J. Pharmacogn. 2019; 6(3):85-98.
  10. Johari S, Sharma A, Sinha S, Das A. Integrating pharmacophore mapping, virtual screening, density functional theory, molecular simulation towards the discovery of novel apolipoprotein (apoE ε4) inhibitors. Comput Biol Chem. 2019 Apr; 79:83-90. (IF. 2.877)
  11. Borah T,Gogoi B, Khataniar A, Gogoi M, Das A,Borah D. Probiotic characterization of indigenous Bacillus velezensis strain DU14 isolated from Apong, a traditionally fermented rice beer of Assam. Biocatal Agric Biotechnol. 2019 Jan; 18:101008. https://doi.org/10.1016/j.bcab.2019.01.046(IF. 3.281)
  12. Pathak K, Das A. Anti-inflammatory study of Leaf extracts of Annona reticulata Linn and HPTLC analysis. Int J Pharma Bio Sci. 2019 Jan; 10(1):68-77.
  13. Pathak K, Das A. Assessment of Anti-oxidant activity of different extracts of Annona reticulata Int J Pharm Sci Res. 2018; 9(6):1000-1008.
  14. Pathak MP, Policegoudra RS, Goyary D, DasA, Mandal S, Chakraborti S, Bora NS, Islam J, Patowary P, Raju PS, Chattopadhyay P. Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays. Drug Chem Toxicol. 2018 Apr; 41(2):147-154.
  15. Pathak K, Das A. Anti-hyperglycemic activity of Leaves of Annona reticulata Linn on Experimental Rat Diabetic Model. European Biomed. Pharm. 2017 Mar; 4(11):674-677.
  16. Ejiofor II, Zaman K, Das A. Effect of Extracts of Vernonia Amygdalina in Helminthiasis-A Tropical Neglected Disease. Pharm Res2017 Dec; 1(8):000147.
  17. Ejiofor II, Zaman K, Das A. Antidiabetic Evaluations of Different Parts of Vernonia Amygdalina. IOSR J Pharm Biol Sci. 2017 Aug; 12(4): 23-28.
  18. Tur J, Badole SD, Cheng F, Das A, Kukreja RC, Tipparaju SM. Corticosteroids and aldose reductase inhibitor Epalrestat modulates cardiac action potential via Kvβ1.1(AKR6A8) subunit of voltage gated potassium channel. Mol Cell Biochem. 2017 Dec; 436(1-2):71-78. (IF. 3.396)
  19. Bhatt HR, Singh UP, Yadav PS, Kumar V, Gahtori P, DasA, Chetia D, Prakash A, Mahanta J. Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine Arab J Chem. 2016; 9:S625-S631.(IF. 5.165)
  20. Bairy PS, Bora NS, Kakoti BB, DasA, Nainwal LM, Gogoi B. Preliminary phytochemical screening, in-vitro antioxidant activity, total polyphenolic and flavonoid content of Garcinia lanceifolia and Citrus maxima (Burm.) Merr. J App Pharm Sci. 2016; 6(9):133-139.
  21. Gahtori P, Pandey R, Kumar V, Ghosh SK, Das A, Kalita JM, Sahu S, Prakash A, Bhattacharyya DR. Toward resistance-compromised DHFR inhibitors part 1: Combined structure/ligand-based virtual screenings and ADME-Tox profiling. J Chemom. 2016 Aug; 30(8):1-20.
  22. Das A,Gogoi U, Kalita J, Sandilya Molecular Docking Study of a Series of Substituted Xanthone Derivatives as Novel COX-2 Inhibitors Targeting Prostaglandin Endoperoxide Synthase -2. Curr Enzym Inhib. 2016; 12(2):195-204.
  23. Das A, Dutta M, Malakar M. In-silico study, synthesis and biological evaluation of some substituted xanthone derivatives as alpha-glucosidase inhibitor. World J Pharm Sci. 2016 Mar; 4(4): 150-161.
  24. Bairy PS, Das A, Nainwal LM, Mahanta TK, Kumawat MK, Mohapatra PK, Parida P. Design, synthesis and anti-diabetic activity of some novel xanthone derivatives targeting α-glucosidase. Bangladesh J Pharmacol. 2016; 11:308-318.
  25. Bairy PS, Shankar B. Das A. Diabetes mellitus and antidiabetics with reference to Alpha Glucosidase Inhibitors. Asian J Biomed Pharm. 2015; 4(6):10-16.
  26. Shankar B, Das A, Parida P. Design, Molecular Docking Study and Synthesis of 3,6-bis(3′-substituted propoxy)xanthone Derivatives as COX-2 Inhibitors. Asian J. Chem. 2015; 27(12):4634-4640.
  27. Nainwal LM, Parida P, Das A, Bairy PS. Design and docking of novel series of hybrid xanthones as anti-cancer agent to target human DNA topoisomerase 2-alpha. Bangladesh J Pharmacol. 2014; 9:208-217.
  28. Parida P, Kalita S, Shankar B, Yadav RNS, Das A. Homology modelling and docking studies of Plasmodium falciparum telomerase reverse transcriptase with berberine and some of its derivatives. Bangladesh J Pharmacol. 2014; 9:96-104.
  29. Das A, Shaikh M, Jana S. Design, synthesis and in vitro antibacterial screening of some novel 3-pentyloxy-1-hydroxyxanthone Derivatives. Med Chem Res. 2014; 23:436-444.
  30. Bairy PS, Das A, Nainwal LM, Shrivastava M. Preliminary Phytochemical Investigation and Anti-inflammatory Activity Studies of Christella arida leaf extract. Proceedings of International conference cum exhibition on Drug Discovery and Development from Natural Resources. 2014; Feb: 126-133.
  31. Das A, Debnath K, Bairy PS, Nainwal LM. Synthesis and antimicrobial screening of a series of 3,6 bis(3’substituted propoxy) and 3,6 bis (5’substitutedpentyloxy) xanthone derivatives. Current Trends in Pharmaceutical Research. 2013; 2(1):13-23.
  32. Boruah L, DasA, Nainwal LM, Agarwal N, Shankar B. In-Silico Drug Design: A revolutionary approach to change the concept of current Drug Discovery Process. Indian J. Pharm. Biol. Res. 2013; June;1(1):60-73.
  33. Das A, Parida P, Agarwal N, Shree J, Shankar B, Chakraborty D. Molecular docking study of 3,6 bis(3’substituted propoxy) and 3,6 bis (5’substitutedpentyloxy) xanthone derivatives as PGHS- 2 inhibitors. J. Appl. Pharm. Sci. 2013 May; 3(4 Suppl.1):S13-S22.
  34. Parida P, Yadav RNS, Shankar B, Chakraborty D, Das A, Singh NK. In-silico protein ligand interaction study of typical antipsychotic drugs against dopaminergic D2 receptor. J. Pharm. Pharm. Sci. 2013; 5(2):183-189.
  35. Jana S, Das Synthesis and Assessment of Antibacterial Activity of some Novel 4-Benzyl-piperazinyl-s-triazine Derivatives. Asian J. Chem. 2013; 25(1):186-190.
  36. Singh RB, Das N, Jana S, Das A. Synthesis and In Vitro Antibacterial Screening of some New 2,4,6 Trisubstituted-1,3,5- Triazine Lett Drug Des Discov. 2012; 9:316-321.
  37. Gahtori P, DasA, Mishra R. Design, Synthesis and Antibacterial Activity of Substituted Phenyl Thiazolyl s-Triazines. Chem. J. 2011 Jul; 45(4):248-252.
  38. Kaushik A, Kaushik JJ, DasA, Gemal S, Gaim D. Preliminary studies on anti-inflammatory activities of Diplazium esculentum in experimental animal models. J. Pharm. Sci. 2011 Apr; 2(5):1251-1253.
  39. Gahtori P, Singh A, Ghosh SK, Das A, Archana U. Synthesis of some substituted Phenythiazolyl 1,3,5-Triazine derivatives. Asian J. Chem. 2011; 23(3):1189-1192.
  40. Singh UP, Das A, Chetia D, Bhattacharya A, Subhaschandra YPK, Kumar V, Bhatt HR, Synthesis and Antibacterial Activity of Some 2,4,6-trisubstituted-1,3,5-triazines. Lat Am J. Pharm. 2010; 29(4):607-611.
  1. Gahtori P, Das A, Bhatt HR. Synthesis and antibacterial assessment of N-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine. Indian J Pharm Sci. 2009 Feb; 71(1):79-82.
  2. Das A, Kaushik A, Jyoti J, Veerma R. Anti-inflammatory activities of Cleome isocandra seed oil in experimental animal models. J. Phytochem. Ayurvedic Heights. 2006 Apr; 2(1):11-13.
  1. Akhtar N, Ali M, Das A. Antibacterial Activity of Inula cuspidate Indian journal Nat. Prod. 2006; 22 (3):33-34.
  2. Kaushik A, Kaushik JJ, DasA, Saini V. Antimycotic effects of essential oil of leaves of Artemesia nilagirica Linn. Indian Perfumer. 2005 Oct; 49(4): 515-517.

Book Chapters:

  1. Das A, Pathak, MP, Chattopadhyay P and Pathak YV. Gene-Based Dietary Advice and Eating Behavior. In: YV Pathak & AM Ardekani (eds), Nutrigenomics and Nutraceuticals: Clinical Relevance and Disease Prevention, 1st Edition, CRC Press. 2017;(515-528).DOI:https://doi.org/10.1201/9781315153711
  1. Das A, Pathak K, Pathak MP, Chattopadhyay P, Saikia R, Sahu S and Gogoi U. Enzyme Inhibition. In: C. Singhla (ed), Recent Advances in Pharmaceutical Sciences., Akinik Publications, New Delhi. 2020; (01-37): ISBN: 978-93-90217-69-4., DOI: https://doi.org/10.22271/ed.book.795
  1. Das A, Saikia R, Pathak K, Gogoi U and Pathak MP. Anti-diabetic Nano-formulation from Herbal Source. In: MK Das & Y Pathak (eds), Nano Medicine and Nano Safety: Recent Trends and Clinical Evidences., Springer, Singapore. 2020; (61-84). Print ISBN 978-981-15-6254-9., DOI: 10.1007/978-981-15-6255-6_4
  1. Pathak K, Pathak MP, Gogoi U, Saikia R and Das A. COVID19: Preventive and Protective Control Management Strategies. Coronaviruses, Bentham Science Publishers Pte. Ltd. Singapore. 2021; Vol. 2: 32-62. ISBN (Print): 978-981-4998-61-1
  1. Das A, Pathak MP, Patowary P, Das S. Introduction to Lung Physiology from a Drug Delivery Perspective. In: Y Pathak & N Islam (eds), Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences. 1st Edition, CRC Press. 2021;(1-11) DOI: https://doi.org/10.1201/9781003046547
  1. Das A, Saikia R, Pathak K, Gogoi U, Saikia S. Chronic Lung Diseases: Treatment, Challenges, and Solutions. In: Pathak Y & Islam N (eds), Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences. 1st Edition, CRC Press. 2021;(57-68) DOI: https://doi.org/10.1201/9781003046547
  1. Saikia S, Das A, Pathak Y. Drug Delivery Using Aerosols: Challenges and Advances in Neonatal Pediatric Subgroup. In: Y Pathak & N Islam (eds), Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences. 1st Edition, CRC Press. 2021; (623-629).DOI: https://doi.org/10.1201/9781003046547
  2. Pathak K, Gogoi U, Pathak MP, Saikia R, Das A. Modified Marine Antidiabetics: An insight into their sources, chemistry, SAR and molecular mechanisms. In: Rahman-Atta-ur(ed), Natural Product Chemistry (Bioactive Natural Products) Elsevier Science.2022 May 27, 1st Edition, Hardcover ISBN: 9780323910972
  3. Saikia S, Das A, Pathak Y. Gold Nanoparticles in Cancer Theranostics. In: Y Pathak & L Kumar (eds), Nanocarriers for Drug- Targeting Brain Tumors. 1st Edition, Elsevier.2022; June 17; Paperback ISBN: 9780323907736.
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