Dr. Dipak Chetia

Professor, Department of Pharmaceutical Sciences
  • Phone No. - 0373-2370254 (O)
  • Department of Pharmaceutical Sciences
  • Designation - Professor

Profile

Education:

  1. Bachelor’s Degree: B. Sc., B. Pharm. (Dibrugarh University)
  2. Master’s Degree: M. Pharm. (Birla Institute of Technology, Mesra)
  3. Ph. D.: Ph. D (Pharmacy) (Jadavpur University, Kolkata)
  4. Other: PDCR (Catalyst Clinical Services, Delhi)

Professional Experience:     

  • 31+ Years (Teaching)

Areas of Interest/ Specialization:

  • Medicinal Chemistry/ Pharmaceutical Chemistry

Research Projects:                

Projects completed as PI/ Coordinator:

Sl. No.

Funding agency (Scheme)

Programme Title

Year of funding (Duration)

Amount sanctioned

01

AICTE

(RPS)

Pharmacognostical and phytochemical study on Caesalpinia crista Linn, a herbal drug having folklore use in the treatment of malaria in Assam

2006

(Three Years)

8.7 Lakh

02

UGC

(Minor Research Project)

Phytochemical investigation and biological evaluation of active principles of the fruits of Garcinia cowa, an indigenous plant of Assam having folklore in the treatment of intestinal protozoal infection

2006

(Two years)

1.0 Lakh

03

UGC

(Minor Research Project)

Phytochemical investigation and Biological evaluation of Sarcochlamys pulcherrima, an indigenous plant of ethnomedicinal importance in Missing community of Assam

2011

(Two years)

1.395 Lakh

04

AICTE

(MODROBS)

Upgradation of laboratory facility for antimalarial activity screening

(as Chief Coordinator)

2012

(One year)

12.72 Lakhs

05

UGC

(UGC-SAP, DRS-I)

Antimalarial drug discovery from natural sources/by chemical synthesis from available lead molecules/through repositioning (as Coordinator)

2016

(Five years)

64.25 Lakhs

Ph.D Scholars:

 

Sl. No.

Name of Scholar

Topic

Status/ Comment

01

Md. Kamaruz Zaman

Pharmacognostical and Phytochemical Investi -gations of some Antimal-arial Herbal Drugs of North-East India

Awarded, 2010

02

Anil Kumar Saikia

Studies on Chemical Composition and Biological Activities of Essential oils of Medicinal and Aromatic plants grown in North East India

Awarded, 2011

03

Aparoop Das

Isolation, Characterization and preparation of Semi-synthetic Derivatives of the Active principles of Garcinia cowa Roxb. and their Biological Evaluation

Awarded, 2012

04

Lalzikpuii

Isolation, Characterization and Biological Evaluation of Active principles of Aporusa oblonga

Awarded, 2013

05

Bhupendra Singh

Synthesis of some novel 4-Aminoquinoline Mannich bases and Evaluation for Antimalarial activity

Awarded, 2014

06

Antesh Jha

Design and Development of Fast Dissolving Drug Delivery Tablets of Glipizide by using Starch and Natural Super Disintegrants

Awarded, 2015

07

Bikash Ch. Deb

Pharmacognostical Characterisation and Biological Evaluation of Sarcochlamys pulcherrima

Awarded, 2015

08

Atul Kumar

Studies on Production of 6-Aminopenicillanic acid by using Locally Isolated Different Free and Immobilized Soil Microbes

Awarded, 2015

09

Mukesh Kr. Kumawat

Synthesis and Antimalarial activity Evaluation of some Novel Tetraoxane Derivatives

Awarded, 2016

10

Kh. Deepak Singh

Evaluation of Biological Activities of Allium hookerii Thw. Enum.

Awarded, 2016

11

Mithun

Rudrapal

Design, Synthesis and Evaluation of 1, 2, 4-Trioxane Derivatives for Antimalarial activity

Awarded, 2018

12

Chandrajit Dohutia

Design, Synthesis and Evaluation of Curcumin derivatives for Antimalarial Activity

Awarded, 2018

13

Partha Pr. Kaishap

(Jt. Guidance with S. Gogoi, NEIST, Jorhat)

Synthesis and biological evaluation of a series of new aza-heterocyclic compounds for anti-inflammatory and cytotoxic activities

Awarded, 2018

14

Biman Bhuyan

Phytochemical and Biological Evaluation of some Costus species of Assam

Awarded, 2018

15

Neelutpal Gogoi

Identification of Antimalarial Phytoconstituents in some selected Traditional Herbal Remedies of Assam

Ongoing

16

Dipankar Nath

Design and Synthesis of Steroid Based Tetraoxane Hybrids as a Strategy for Development of Novel Antimalarials

Ongoing

17

Dubom Tayeng

Development of Antimalarial Herbal Formulation based on Traditional Remedies of Arunachal Pradesh

Ongoing

18 James H. Zothantluanga Investigation on Ilex umbellulata (Wall.) Loes, a herbal remedy of Mizoram for antimalarial effectiveness by phytochemical, biological, and computational approaches Ongoing
19 Malita Sarma Development of Potential Antimalarial Hybrids of 1,4-Naphthoquinone and Pyrimidine Derivatives 

Ongoing

 

Administrative Assignments:

  • Dean, Research & Development, Dibrugarh University

Extension Service:

  • Professional activities

 

Publications

Papers published in Journals:

01) Chetia D, Nath LK, Dutta SK. Extraction, Purification and Physico-chemical Properties of a Proteolytic Enzyme from the Latex of Ficus hispida Linn. Indian J. Pharm. Sci. 1999; 61(1): 29-33

02) Chetia D, Nath LK, Dutta SK. Purification and characterization of a Protease from Ficus hispida Linn. Indian J. Pharm. Sci. 2001; 63(2): 132-136

03) Chetia D, Nath LK, Dutta SK. Pharmacological Properties of a Protease from Ficus hispida Linn. Ancient Science of Life. 2001; Vol XXI (2): 99-110

04) Chetia D, Zaman K. Pharmacognostic studies of the trunk bark of Machilus bombycina (Persia bombycina) King ex Hook. f. Bull. Life Sci. 2008; Vol- XIV: 1-10

05) Zaman K, Chetia D, Saikia AK, Ali M. Essential oil composition of leaves and fruits of Litsea cubeba Pers. grown in upper Assam region of India. Bull. Life Sci. 2008; Vol-XIV: 20-25

06) Singh B, Kumawat MK, Chetia D. Synthesis and Evaluation of 7-Chloro-4-Aminoquinoline Mannich base Derivatives for Antimalarial Activity. Bull. Life Sci. 2008; Vol. XIV: 11-19

07) Saha C, Bhattacharya S, Chetia D. Synthesis and Antimalarial Screening of Some New Isoquine Analogues. Int. J. ChemTech Res. 2009; 1(2): 322-328

08) Longchar S, Bora S, Chetia D. Study on the Pattern of Drug Usage in Urban Areas of Nagaland. Bull. Life Sci. 2009; Vol. XV: 77-82

09) Saha C, Bhattacharya S, Chetia D. Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity, E-Journal of Chemistry. 2009; 6(S): S381-S389  

10) Rudrapal M, Chetia D, Prakash A. Synthesis and antimalarial activity evaluation of some new 7-chloro-4-aminoquinolines with substituted ring at side chain. Der Pharma Chemica. 2010; 2(1): 194-203

11) Rudrapal M, Chetia D. Synthesis and antibacterial activity evaluation of some novel 7-chloro-4-aminoquinoline derivatives. Int. Journal of ChemTech Research.2010; 2 (3): 1606-1611 

12) Singh UP, Das A, Chetia D, Bhattacharya A, Subhasch YP, Kumar V, Bhatt HR. Synthesis and Antibacterial Activity of Some 2,4,6-trisubstituted-1,3,5-triazines, Lat. Am. J. Pharm. 2010; 29 (4): 607-11

13) Rudrapal M, Chetia D. Synthesis and antibacterial Activity Screening of some 4-aminoquinolines with substituted ring at side chain. Indian J Pharm Sciences. 2010; 72 (2): 278 

14) Singh B, Chetia D, Puri SK, Srivastava K, Prakash A. Synthesis and in vitro and in vivo antimalarial activity of novel 4-anilinoquinoline Mannich base derivatives. Med Chem Res. 2011; 20:1523–1529 

15) Bora S, Chetia D, Prakash A. Synthesis and antimalarial activity evaluation of some isoquine analogues. Med Chem Res.  2011; 20 (9): 1632-1637 

16) Chetia D, Nada N, Rudrapal M. Study on the Use of Medicines in some Selected Healthcare Facilities of Arunachal Pradesh. Asian J Pharm Clin Res. 2011; 4(3): 80-81

17) Jha AK, Chetia D. Development and Statistical Analysis of Glipizide-loaded Fast-dissolving Tablets Using Plantago ovata Husk as a Superdisintegrant. International Journal of Pharmaceutical Compounding. 2011; 15(6): 521-525

18) Jha AK, Chetia D. Formulation and evaluation of glipizide-loaded Fast-Dissolving Tablets using husk of Plantugo ovata as a superdisintegrant. Asian Journal of Pharmaceutics. 2011; 5(4): 198-202

19) Jha AK, Chetia D. Development of natural gum based fast disintegrating tablets of glipizide. Asian Journal of Pharmaceutics. 2012; 6(4): 282-288

20) Rajesh Singh Y, Ch. Onita Devi, S. Kr. Singh A., Chetia D. Study on the Ethnomedicinal System of Manipur. International Journal of Pharmaceutical & Biological Archives. 2012; 3(3): 507-511

21) Sailo Lalzikpuii, Sailo L, Chetia D. Studies on Antiinflammatory, Antipyretic and Analgesic Activities of Aporusa oblonga Mull Arg. Asian J. Chem. 2012; 24 (11): 4995-4999

22) Kaishap PP, Dohutia C, Chetia D. Synthesis and study of analgesic, anti-inflammatory activities of bis (indolyl) methanes (BIMS). IJPSR. 2012; 3(11): 1000-1006

23) Roy S, Chetia D, Rudrapal M, Prakash A. Synthesis and in-vitro Antimalarial Activity of Some New 4-Amino quinoline Mannich Base Derivatives. International Journal of Drug Design and Discovery. 2012; 3(2): 803-808

24) Singh KD, Chetia D. Phytochemical Screening and Gut Motility Activity of Pongamia pinnata Bark in Experimental Animal Models. Int J Pharm Bio Sci. 2013; 4(1): 63-69

25) Dohutia C, Kaishap PP, Chetia D. Synthesis and Study of Analgesic, Anti-inflammatory Activities of 3-Methyl-5-pyrazolone Derivatives. Int J Pharm Pharm Sci. 2013; 5(1): 86-90

26) Saikia AK, Chetia D, D’Arrigob M, Smeriglio A, Strano T, Ruberto G. Screening of fruit and leaf essential oils of Litsea cubeba Pers. from north-east India – chemical composition and antimicrobial activity. The Journal of Essential Oil Research. 2013; 25(4): 1-9

27) Kumari B, Chetia D. In-silico docking studies of selected n-glycoside bearing tetrazole ring in the treatment of hyperglycemia showing inhibitory activity on SGLT. Int J Pharm Pharm Sci. 2013; 5, Suppl 2: 633-638

28) Roy S, Chetia D, Rudrapal M, Prakash A. Synthesis and Antimalarial Activity Study of Some New Mannich Bases of 7-Chloro-4-Aminoquinoline. Medicinal Chemistry. 2013;  9 (3): 379-383

29) Sharma RB, Chetia D. Docking studies on quinine analogs for Plasmepsin-II of malaria parasite using Bioinformatics tools. Int J Pharm Pharm Sci. 2013; 5, Suppl 3: 681-685

30) Sharma RB, Deka RC, Sharma HK, Chetia D. Pharmacophore Mapping, Three Dimensional QSAR Analysis and Docking Study of Quinoline Derivatives as Potent Plasmepsin Inhibitors. International Journal of Recent Scientific Research. 2013; 4(11): 1871-1874

31) Bhuyan B, Chetia D, Rajak P. Preliminary Phytochemical Investigation on Rhizomes of Costus speciosus found in Assam, India. PHARMANEST. 2013; 4(6): 447-1457

32) Singh KD, Chetia D, Mazumdar S. Antidiabetic activity of methnolic extract of Allium hookerii leaves. Indo American Journal of Pharm Research. 2013; 3(6): 4098-4104

33) Rudrapal M, Chetia D, Prakash A. Synthesis, antimalarial-, and antibacterial activity evaluation of some new 4-aminoquinoline derivatives. Med Chem Res. 2013; 22: 3703–3711

34) Jha AK, Chetia D. In vitro-in vivo performance evaluation of treated Plantago ovata husk based fast dissolving tablets of glipizide: Flashtab technology. Asian J Pharm. 2014; 8(4): 250-258

35) Deb BC, Kumar A, Chetia D. Pharmacognostical studies on the leaves of Sarcochlamys pulcherrima (Roxb) Goud. Indian Journal of Natural Products and Resources. 2014; 5 (2): 164-170

36) Singh KD, Chetia D, Junejo JA. Antiulcer and in vitro antioxidant activity of Allium hookerii: an ethnomedicinal plant of Manipur. Asian J Pharm Clin Res, 2015; 8(5): 130-135

37) Kumawat MK, Chetia D. Molecular docking studies of some novel 1,2,4,5-tetraoxane derivatives as antimalarial agents. World Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(10): 890-908

38) Kumawat MK, Chetia D. Synthesis, antimalarial activity evaluation and molecular docking studies of some novel dispiro-1,2,4,5-tetraoxanes. Bangladesh J Pharmacol. 2015; 10(4): 917-923

39) Sharma D, Chetia D, Rudrapal M. Design, Synthesis and Antimalarial Activity of Some New 2-Hydroxy-1,4-naphthoquinone-4-hydroxyaniline Hybrid Mannich Bases. Asian J. Chem. 2016; 28 (4): 782-788

40) Kumawat MK, Chetia D, Parida P. Synthesis, antimalarial activity evaluation and docking studies of some novel tetraoxaquines. Med Chem Res. 2016; 25: 1993-2004

41) Kumawat MK, Chetia D. Molecular docking studies of some novel hybrid tetraoxaquines & dispirotetraoxanes as antimalarial agents. Int J Pharm Sci Res. 2016; 7(3): 1348-1359

42) Sarma M, Chetia D, Singh KD, Banu ZW, Dohutia C. Synthesis and evaluation of hybrid Mannich base-tetraoxane derivatives as potent anti-malarial agents. Int J Pharm Anal Res. 2016; 5(2): 287-293

43) Rudrapal M, Chetia D. QSAR Analysis of 7-Chloro-4-Aminoquinoline Derivatives as Antimalarial Agents. Asian J Org Med Chem. 2016; 1(2): 51-54

44) Kumawat MK, Singh UP, Singh B, Prakash A, Chetia D. Synthesis and Antimalarial Activity Evaluation of 3-(3-(7-chloroquinolin-4-ylamino) propyl)-1,3-thiazinan-4-one Derivatives. Arabian Journal of Chemistry. 2016; 9: S643-S647

45) Gogoi J, Chetia D, Kumawat MK, Rudrapal M. Synthesis and Antimalarial Activity Evaluation of Some Mannich Bases of Tetraoxane-Phenol Conjugate. Indian Journal of Pharmaceutical Education and Research. 2016; 50(4): 591-597

46) Rudrapal M, Chetia D. Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.  Drug Design, Development and Therapy. 2016; 10: 3575–3590

47) Dohutia C, Chetia D, Singh KD. Curcumin Against Malaria: From Traditional Medicine to Development of Synthetic Analogs- A Bioorganic Approach. Current Traditional Medicine. 2016; 2(2): 124-133

48) Sharma R, Goswami A, Rudrapal M, Sharma D, Sharma HK, Chetia D. In vitro evaluation of the antimalarial activity of a designed novel quinuclidine derivative. Current Science. 2016; 111(12): 2028-2030

49) Kashyap A, Chetia D, Rudrapal M. Synthesis, Antimalarial Activity Evaluation and Drug-likeness Study of Some New Quinoline-Lawsone Hybrids. Indian J Pharm Science. 2016; 78(6): 892-911

50) Dohutia C, Chetia D, Upadhyaya S. Ethno-medicinal Survey on Tai-Ahom Community of Assam. Ethno Med. 2016; 10(4): 461-471

51) Rudrapal M, Chetia D. QSAR study of trioxane derivatives as antimalarial agents. Curr Trend Pharm Res. 2016; 3(1): 1-17

52)  Gogoi G, Borua PK, Chetia D. GA3 Assisted Seed Dormancy Breaking in Abelmoschus mochatus Medic. Subsp. Mochatus. Cercetari Agronomice in Moldova. 2016; 49(4): 27-34

53) Zaman K, Chetia D, Ali M. Isolation of Two New Cheilanthane-Type Tricarboxylic Sesterterpenoids from Leaves of Caesalpinia crista Linn.: A Traditionally Used Plant of Assam, India. Asian J. Chem. 2017; 29 (3): 485-488

54) Kaishap PP, Duarah G, Chetia D, Gogoi S. Ru (II)-Catalyzed annulation of benzamidines and alkynes by C–H/ N–H activation: a facile synthesis of 1-amino isoquinolines. Org. Biol. Chem. 2017; 15: 3491-3498

55) Dohutia C, Chetia D, Gogoi K, Sarma K. Design, in silico and in vitro evaluation of curcumin analogues against Plasmodium falciparum. Experimental Parasitology. 2017; 175: 51–58

56) Rudrapal M, Chetia D, Singh V. Novel series of 1,2,4-trioxane derivatives as antimalarial agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2017; 32 (1): 1159–1173

57) Dohutia C, Chetia D, Gogoi K, Bhattacharyya DR, Sarma K. Molecular docking, synthesis and in vitro antimalarial evaluation of certain novel curcumin analogues. Braz. J. Pharm. Sci. 2017; 53(4): 1-14

58) Rudrapal M, Chetia D. Plant flavonoids as potential source of future antimalarial leads. Systematic Reviews in Pharmacy. 2017; 8 (1): 13-18

59) Kaishap PP, Duarah G, Sarma B, Chetia D, Gogoi S. Ruthenium (II)-Catalyzed Synthesis of Spirobenzofuranones by a Decarbonylative Annulation Reaction. Angew. Chem. Int. Ed. 2018; 57(2): 456 –460

60) Rudrapal M, Banu ZW, Chetia D. Newer series of trioxane derivatives as potent antimalarial agents. Med Chem Res. 2018; 27: 653–668

61) Medhi A, Chetia D, Rudrapal M. Synthesis and Antimalarial Activity of Lawsone Mannich Base Derivatives. Indian Journal of Pharmaceutical Education and Research. 2018; 52(3): 472-479

62) Bhuyan B, Chetia D. An ethnomedicinal study focusing the genus Costus in Assam with emphasis on traditional medicine. Journal of Medicinal Plants. 2018; 6(2): 178-188

63) Gogoi K, Chetia D, Barua NC, Gogoi N, Dohutia C. In vitro Antimalarial Evaluation and Molecular Docking Analysis of Mannich Base Curcumin Analogues against the Artemisinin Target PfATP6. Asian Journal of Pharmacy and Pharmacology. 2019; 5 (1): 120-128

64) Patowary P, Chetia D, Kalita J, Rudrapal M. Design, Synthesis and Antimalarial Activity of Flavonoid Derivatives. Indian J Heterocycl Chem.  2019; 29 (1): 53-58

65) Rudrapal M, Chetia D. Development of Trioxances as Novel Antimalarial agents.  Curr Trends Pharm Res. 2019; 6(2): 120-127

66) Kalita J, Chetia D, Rudrapal M. Molecular Docking, Drug-likeness Studies and ADMET Prediction of Quinoline Imines for Antimalarial Activity. J Med Chem Drug Des. 2019; 8(2): 208-218

67) Gogoi N, Chetia D. Preliminary validation of ethnomedicinal plants used in the preparation of antimalarial herbal remedies by in vitro screening method. Curr Trend Pharm Res. 2019; 6(1): 63-75

68) Kumawat MK, Singh UP, Chetia D. Design and discovery of 3,6-substituted 1,2,4,5-tetraoxanes as new class of falcipain-2 inhibitors for antimalarial action. Pharmaceutical Chemistry Journal.  2019; 53 (9): 822-830

69) Bhuyan B, Chetia D. In vivo Validation of Folkloric Use of Costus pictus D. Don as Antidiabetic Plant in Assam, using Streptozotocin Induced Wister Rat Model. Ind J Clin Biochem. 2019; 35(2): 225-231

70) Rudrapal M, Chetia D. Virtual Screening, Molecular Docking and QSAR Studies in Drug Discovery and Development Programme. Journal of Drug Delivery and Therapeutics. 2020; 10(4): 225-233

71) Kalita J, Chetia D, Rudrapal M. Design, Synthesis, Antimalarial Activity and Docking Study of 7-Chloro-4-(2-(substituted benzylidene) hydrazineyl) quinolines. Medicinal Chemistry. 2020; 16 (7): 928-937

72) Gogoi B, Gogoi N, Chowdhury P, Chetia D. Repurposing of FDA approved antibiotics as antimalarial agents: A network pharmacology based in silico approach.  International Journal of Infectious Diseases. 2020; 101(S1): 116-117

73) Garg A, Borah D, Trivedi P, Gogoi D, Chaliha AK, Ali AA, Chetia D, Chaturvedi V, Sarma D. A Simple Work-Up-free, Solvent-free Approach to Novel Amino Acid Linked 1, 4-Disubstituted 1, 2, 3-Triazoles as Potent Antituberculosis Agents. ACS omega. 2020; 5(46): 29830-29837

74) Mahanta S,  Chowdhury P,  Gogoi N, Goswami N,  Borah D, Kumar R,  Chetia D, Borah P, Buragohain AK,  Gogoi B. Potential anti-viral activity of approved repurposed drug against main protease of SARS-CoV-2: an in silico based approach. Journal of Biomolecular Structure and Dynamics. 2021; 39 (10): 3802-3811

75) Gogoi B, Chowdhury P, Goswami N, Gogoi N, Naiya T, Chetia P, Mahanta S, Chetia D, Tanti B, Borah P, Handique PJ. Identification of potential plant-based inhibitor against viral proteases of SARS-CoV-2 through molecular docking, MM-PBSA binding energy calculations and molecular dynamics simulation. Molecular diversity. 2021; 25(3): 1963-1977

76) Gogoi N, Chetia, D, Gogoi B, Das A. Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In-Silico and Whole Cell-based In vitro Approach. Current Computer-Aided Drug Design. 2021; 17 (1): 69-82

77) Gogoi N, Gogoi B, Chetia D. In vitro antimalarial activity evaluation of two ethnomedicinal plants against chloroquine sensitive and resistant strains of Plasmodium falciparum. Clinical Phytoscience. 2021; 7(1): 1-10

78) Othman IMM, Mahross MH, Gad-Elkareem MAM, Rudrapal M, Gogoi N, Chetia D, Aouadi K, Snoussi M, Kadri A. Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel aryl hydrazothiazolyl sulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations. Journal of Molecular Structure. 2021; 1243(2): 130862

79) Patowary L, Kashyap P, Chetia D, Gogoi N. Docking based virtual screening of some new 4-Aminoquinolines against PfCRT. Curr Trends Pharm Res. 2021; 8(1): 212-226

80) Gogoi N, Chowdhury P, Goswami AK, Das A, Chetia D, Gogoi B. Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease. Molecular Diversity. 2021; 25(3): 1745-1759

81) Ghosh S, Chetia D, Gogoi N, Rudrapal M. Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors. BioTechnologia. 2021; 102(3): 257-275

82) Gogoi N, Chetia D, Gogoi B, Das A. Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In-Silico and Whole Cell-based In vitro Approach. Curr Comput Aided Drug Des. 2021; 17(1): 69-82

83) Kumawat MK, Chetia D. Synthesis, Antimalarial Activity Evaluation and Molecular Docking Studies of some new substituted Spiro-1,2,4,5-tetraoxane Derivatives. Pharm Chem J. 2021; 55(8): 814-820

84) Singh B, Chetia D, Kumawat MK. Synthesis and In Vitro Antimalarial Activity Evaluation of Some New 1, 2-Diaminopropane Side-Chain-Modified 4-Aminoquinoline Mannich Bases. Pharm Chem J. 2021; 55 (7): 724-731

85) Zothantluanga JH, Gogoi N, Shakya A, Chetia D, Lalthanzara H. Computational guided identification of potential leads from Acacia pennata (L.) Willd. as inhibitors for cellular entry and viral replication of SARS-CoV-2.  Futur J Pharm Sci. 2021; 7(201): 1-18

86) Rudrapal M, Gogoi N, Chetia D, Khan J, Banwas S, B Alshehri, Alaidarous MA, Laddha UD, Khainar SJ, Walode SG. Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness/ADMET studies. Saudi J Biol Sci. 2022; 29 (4): 2432-2446 

87) Rudrapal M, Celik I, Khan J, Ansari MA, Alomary MN, Yadav R, Sharma T, Trina Tallei TE, Pasala PK, Sahoo RK, Khairnar SJ, Bendale AR, Zothantluanga JH, Chetia D, Walode SG. Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through computational investigations. Journal of King Saud University – Science. 2022; 34 (2022) 101826

88) Ezugwu JA, Okoro UC, Ezeokonkwo MA, Hariprasad KS, Rudrapal M, Ugwu DI, Gogoi N, Chetia D, Celik I, Ekoh OC. Design, Synthesis, Molecular Docking, Molecular Dynamics and in-vivo Antimalarial Activity of New Dipeptide-Sulfonamides, ChemistrySelect, 2022; doi.org/10.1002/slct.202103908

89) Zothantluanga JH, Abdalla M, Rudrapal M, Tian Q, Chetia D & Li J. Computational Investigations for Identification of Bioactive Molecules from Baccaurea ramiflora and Bergenia ciliata as Inhibitors of SARS-CoV-2 Mpro. Polycyclic Aromatic Compounds, 2022; DOI: 10.1080/10406638.2022.2046613

90) Umar AK, Zothantluanga JH, Aswin K, Moulana S, Zubair MS, Lalhlenmawia, Rudrapal M, Chetia D. Antiviral phytocompounds “ellagic acid” and “(+)-sesamin” of Bridelia retusa identified as potential inhibitors of SARS-CoV-2 3CL pro using extensive molecular docking, molecular dynamics simulation studies, binding free energy calculations, and bioactivity prediction. Struct Chem, 2022; doi.org/10.1007/s11224-022-01959-3

91) Patowary L, Borthakur MS, Zothantluanga JH, Chetia D. Repurposing of FDA approved drugs having structural similarity to artemisinin against PfDHFR-TS through molecular docking and molecular dynamics simulation studies. Curr Trends Pharm Res, 2022; 8 (2): 14-34.

92) Gogoi NChowdhury PGoswami AKDas AChetia DGogoi B.  Integrated computational approach towards repurposing of antimalarial drug against SARS-CoV-2 main protease. Struct Chem, 2022; doi: 10.1007/s11224-022-01916-0.

Books and Book Chapters:

Books Published/Edited:

 1. Dolui AK (Ed), Das S, Chetia D. (Associate Editors). Management of Natural Resources for Better Health Care (Proceedings of National Seminar, Dept. of Pharm. Sciences, Dibrugarh University). Registrar, Dibrugarh University. 2002; ISBN: 81-88424-00-5

 2. Zothantluanga JH, Lalthanzara H, Shakya A, Chetia D. The outbreak of COVID-19 in Mizoram, India. Rizug, Guwahati. 2020; ISBN: 978-81-941388-6-0

Book Chapters:

1) Rudrapal M, Chetia D, Sarwa KK, Bhattacharya S. Nanotoxicity: Physicochemical and Biological (PK-PD) Perspectives. In: Rauta PR, Mohanta YK, Nayak D. (Eds). Nanotechnology in Biology and Medicine: Research Advancements & Future Perspectives. CRC Press; 2019: ISBN: 9780429259333

2)  Rudrapal M, Chetia D.  Herbal Drugs: Efficacy, Toxicity, and Safety Issues. In: Mandal SC, Chakraborty R, Sen S. (Eds.) Evidence-Based Validation of Traditional Medicines-A Comprehensive Approach. Springer Nature Singapore Pte Ltd.; 2021: ISBN 978-981-15-8126-7, ISBN 978-981-15-      8127-4 (eBook)

3)  Rudrapal M, Chetia D.  Malaria and Recent Developments in Antimalarial Drugs. In: Egbuna C, Akram M, Ifemeje JC. (Eds.) Neglected Tropical Diseases and Phytochemicals in Drug Discovery. John Wiley & Sons, Inc.; 2022: Print ISBN:9781119616603; Online ISBN: 9781119617143

4)  Bhuyan B, Chetia D and Prakash Rajak P. Traditional Usage of Plants of Costus Species in Assam, India. In: El-Shemy HA (Ed). Natural Medicinal Plants. DOI10.5772/intechopen.91542; 2022: ISBN: 978-1-83969-276-5; PRINT ISBN: 978-1-83969-275-8

 

Courses Taken

 1) Course Name: Instrumental Methods of Analysis-Theory, Course Code: BP701T

2) Course Name: Instrumental Methods of Analysis-Practical, Course Code: BP705P

3) Course Name: Modern Pharmaceutical Analytical Techniques, Course Code: MPH101T/ MPC101T/ MPL101T/ MPG101T

4) Course Name: Pharmaceutical Chemistry Practical I, Course Code: MPC105P

5) Course Name: Advance Spectral Analysis, Course Code: MPC201T

6) Course Name: Pharmaceutical Chemistry Practical II, Course Code: MPC205P

Profile

Profile

Education:

  1. Bachelor’s Degree: B. Sc., B. Pharm. (Dibrugarh University)
  2. Master’s Degree: M. Pharm. (Birla Institute of Technology, Mesra)
  3. Ph. D.: Ph. D (Pharmacy) (Jadavpur University, Kolkata)
  4. Other: PDCR (Catalyst Clinical Services, Delhi)

Professional Experience:     

  • 31+ Years (Teaching)

Areas of Interest/ Specialization:

  • Medicinal Chemistry/ Pharmaceutical Chemistry

Research Projects:                

Projects completed as PI/ Coordinator:

Sl. No.

Funding agency (Scheme)

Programme Title

Year of funding (Duration)

Amount sanctioned

01

AICTE

(RPS)

Pharmacognostical and phytochemical study on Caesalpinia crista Linn, a herbal drug having folklore use in the treatment of malaria in Assam

2006

(Three Years)

8.7 Lakh

02

UGC

(Minor Research Project)

Phytochemical investigation and biological evaluation of active principles of the fruits of Garcinia cowa, an indigenous plant of Assam having folklore in the treatment of intestinal protozoal infection

2006

(Two years)

1.0 Lakh

03

UGC

(Minor Research Project)

Phytochemical investigation and Biological evaluation of Sarcochlamys pulcherrima, an indigenous plant of ethnomedicinal importance in Missing community of Assam

2011

(Two years)

1.395 Lakh

04

AICTE

(MODROBS)

Upgradation of laboratory facility for antimalarial activity screening

(as Chief Coordinator)

2012

(One year)

12.72 Lakhs

05

UGC

(UGC-SAP, DRS-I)

Antimalarial drug discovery from natural sources/by chemical synthesis from available lead molecules/through repositioning (as Coordinator)

2016

(Five years)

64.25 Lakhs

Ph.D Scholars:

 

Sl. No.

Name of Scholar

Topic

Status/ Comment

01

Md. Kamaruz Zaman

Pharmacognostical and Phytochemical Investi -gations of some Antimal-arial Herbal Drugs of North-East India

Awarded, 2010

02

Anil Kumar Saikia

Studies on Chemical Composition and Biological Activities of Essential oils of Medicinal and Aromatic plants grown in North East India

Awarded, 2011

03

Aparoop Das

Isolation, Characterization and preparation of Semi-synthetic Derivatives of the Active principles of Garcinia cowa Roxb. and their Biological Evaluation

Awarded, 2012

04

Lalzikpuii

Isolation, Characterization and Biological Evaluation of Active principles of Aporusa oblonga

Awarded, 2013

05

Bhupendra Singh

Synthesis of some novel 4-Aminoquinoline Mannich bases and Evaluation for Antimalarial activity

Awarded, 2014

06

Antesh Jha

Design and Development of Fast Dissolving Drug Delivery Tablets of Glipizide by using Starch and Natural Super Disintegrants

Awarded, 2015

07

Bikash Ch. Deb

Pharmacognostical Characterisation and Biological Evaluation of Sarcochlamys pulcherrima

Awarded, 2015

08

Atul Kumar

Studies on Production of 6-Aminopenicillanic acid by using Locally Isolated Different Free and Immobilized Soil Microbes

Awarded, 2015

09

Mukesh Kr. Kumawat

Synthesis and Antimalarial activity Evaluation of some Novel Tetraoxane Derivatives

Awarded, 2016

10

Kh. Deepak Singh

Evaluation of Biological Activities of Allium hookerii Thw. Enum.

Awarded, 2016

11

Mithun

Rudrapal

Design, Synthesis and Evaluation of 1, 2, 4-Trioxane Derivatives for Antimalarial activity

Awarded, 2018

12

Chandrajit Dohutia

Design, Synthesis and Evaluation of Curcumin derivatives for Antimalarial Activity

Awarded, 2018

13

Partha Pr. Kaishap

(Jt. Guidance with S. Gogoi, NEIST, Jorhat)

Synthesis and biological evaluation of a series of new aza-heterocyclic compounds for anti-inflammatory and cytotoxic activities

Awarded, 2018

14

Biman Bhuyan

Phytochemical and Biological Evaluation of some Costus species of Assam

Awarded, 2018

15

Neelutpal Gogoi

Identification of Antimalarial Phytoconstituents in some selected Traditional Herbal Remedies of Assam

Ongoing

16

Dipankar Nath

Design and Synthesis of Steroid Based Tetraoxane Hybrids as a Strategy for Development of Novel Antimalarials

Ongoing

17

Dubom Tayeng

Development of Antimalarial Herbal Formulation based on Traditional Remedies of Arunachal Pradesh

Ongoing

18 James H. Zothantluanga Investigation on Ilex umbellulata (Wall.) Loes, a herbal remedy of Mizoram for antimalarial effectiveness by phytochemical, biological, and computational approaches Ongoing
19 Malita Sarma Development of Potential Antimalarial Hybrids of 1,4-Naphthoquinone and Pyrimidine Derivatives 

Ongoing

 

Administrative Assignments:

  • Dean, Research & Development, Dibrugarh University

Extension Service:

  • Professional activities

 

Publications

Publications

 

Papers published in Journals:

01) Chetia D, Nath LK, Dutta SK. Extraction, Purification and Physico-chemical Properties of a Proteolytic Enzyme from the Latex of Ficus hispida Linn. Indian J. Pharm. Sci. 1999; 61(1): 29-33

02) Chetia D, Nath LK, Dutta SK. Purification and characterization of a Protease from Ficus hispida Linn. Indian J. Pharm. Sci. 2001; 63(2): 132-136

03) Chetia D, Nath LK, Dutta SK. Pharmacological Properties of a Protease from Ficus hispida Linn. Ancient Science of Life. 2001; Vol XXI (2): 99-110

04) Chetia D, Zaman K. Pharmacognostic studies of the trunk bark of Machilus bombycina (Persia bombycina) King ex Hook. f. Bull. Life Sci. 2008; Vol- XIV: 1-10

05) Zaman K, Chetia D, Saikia AK, Ali M. Essential oil composition of leaves and fruits of Litsea cubeba Pers. grown in upper Assam region of India. Bull. Life Sci. 2008; Vol-XIV: 20-25

06) Singh B, Kumawat MK, Chetia D. Synthesis and Evaluation of 7-Chloro-4-Aminoquinoline Mannich base Derivatives for Antimalarial Activity. Bull. Life Sci. 2008; Vol. XIV: 11-19

07) Saha C, Bhattacharya S, Chetia D. Synthesis and Antimalarial Screening of Some New Isoquine Analogues. Int. J. ChemTech Res. 2009; 1(2): 322-328

08) Longchar S, Bora S, Chetia D. Study on the Pattern of Drug Usage in Urban Areas of Nagaland. Bull. Life Sci. 2009; Vol. XV: 77-82

09) Saha C, Bhattacharya S, Chetia D. Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity, E-Journal of Chemistry. 2009; 6(S): S381-S389  

10) Rudrapal M, Chetia D, Prakash A. Synthesis and antimalarial activity evaluation of some new 7-chloro-4-aminoquinolines with substituted ring at side chain. Der Pharma Chemica. 2010; 2(1): 194-203

11) Rudrapal M, Chetia D. Synthesis and antibacterial activity evaluation of some novel 7-chloro-4-aminoquinoline derivatives. Int. Journal of ChemTech Research.2010; 2 (3): 1606-1611 

12) Singh UP, Das A, Chetia D, Bhattacharya A, Subhasch YP, Kumar V, Bhatt HR. Synthesis and Antibacterial Activity of Some 2,4,6-trisubstituted-1,3,5-triazines, Lat. Am. J. Pharm. 2010; 29 (4): 607-11

13) Rudrapal M, Chetia D. Synthesis and antibacterial Activity Screening of some 4-aminoquinolines with substituted ring at side chain. Indian J Pharm Sciences. 2010; 72 (2): 278 

14) Singh B, Chetia D, Puri SK, Srivastava K, Prakash A. Synthesis and in vitro and in vivo antimalarial activity of novel 4-anilinoquinoline Mannich base derivatives. Med Chem Res. 2011; 20:1523–1529 

15) Bora S, Chetia D, Prakash A. Synthesis and antimalarial activity evaluation of some isoquine analogues. Med Chem Res.  2011; 20 (9): 1632-1637 

16) Chetia D, Nada N, Rudrapal M. Study on the Use of Medicines in some Selected Healthcare Facilities of Arunachal Pradesh. Asian J Pharm Clin Res. 2011; 4(3): 80-81

17) Jha AK, Chetia D. Development and Statistical Analysis of Glipizide-loaded Fast-dissolving Tablets Using Plantago ovata Husk as a Superdisintegrant. International Journal of Pharmaceutical Compounding. 2011; 15(6): 521-525

18) Jha AK, Chetia D. Formulation and evaluation of glipizide-loaded Fast-Dissolving Tablets using husk of Plantugo ovata as a superdisintegrant. Asian Journal of Pharmaceutics. 2011; 5(4): 198-202

19) Jha AK, Chetia D. Development of natural gum based fast disintegrating tablets of glipizide. Asian Journal of Pharmaceutics. 2012; 6(4): 282-288

20) Rajesh Singh Y, Ch. Onita Devi, S. Kr. Singh A., Chetia D. Study on the Ethnomedicinal System of Manipur. International Journal of Pharmaceutical & Biological Archives. 2012; 3(3): 507-511

21) Sailo Lalzikpuii, Sailo L, Chetia D. Studies on Antiinflammatory, Antipyretic and Analgesic Activities of Aporusa oblonga Mull Arg. Asian J. Chem. 2012; 24 (11): 4995-4999

22) Kaishap PP, Dohutia C, Chetia D. Synthesis and study of analgesic, anti-inflammatory activities of bis (indolyl) methanes (BIMS). IJPSR. 2012; 3(11): 1000-1006

23) Roy S, Chetia D, Rudrapal M, Prakash A. Synthesis and in-vitro Antimalarial Activity of Some New 4-Amino quinoline Mannich Base Derivatives. International Journal of Drug Design and Discovery. 2012; 3(2): 803-808

24) Singh KD, Chetia D. Phytochemical Screening and Gut Motility Activity of Pongamia pinnata Bark in Experimental Animal Models. Int J Pharm Bio Sci. 2013; 4(1): 63-69

25) Dohutia C, Kaishap PP, Chetia D. Synthesis and Study of Analgesic, Anti-inflammatory Activities of 3-Methyl-5-pyrazolone Derivatives. Int J Pharm Pharm Sci. 2013; 5(1): 86-90

26) Saikia AK, Chetia D, D’Arrigob M, Smeriglio A, Strano T, Ruberto G. Screening of fruit and leaf essential oils of Litsea cubeba Pers. from north-east India – chemical composition and antimicrobial activity. The Journal of Essential Oil Research. 2013; 25(4): 1-9

27) Kumari B, Chetia D. In-silico docking studies of selected n-glycoside bearing tetrazole ring in the treatment of hyperglycemia showing inhibitory activity on SGLT. Int J Pharm Pharm Sci. 2013; 5, Suppl 2: 633-638

28) Roy S, Chetia D, Rudrapal M, Prakash A. Synthesis and Antimalarial Activity Study of Some New Mannich Bases of 7-Chloro-4-Aminoquinoline. Medicinal Chemistry. 2013;  9 (3): 379-383

29) Sharma RB, Chetia D. Docking studies on quinine analogs for Plasmepsin-II of malaria parasite using Bioinformatics tools. Int J Pharm Pharm Sci. 2013; 5, Suppl 3: 681-685

30) Sharma RB, Deka RC, Sharma HK, Chetia D. Pharmacophore Mapping, Three Dimensional QSAR Analysis and Docking Study of Quinoline Derivatives as Potent Plasmepsin Inhibitors. International Journal of Recent Scientific Research. 2013; 4(11): 1871-1874

31) Bhuyan B, Chetia D, Rajak P. Preliminary Phytochemical Investigation on Rhizomes of Costus speciosus found in Assam, India. PHARMANEST. 2013; 4(6): 447-1457

32) Singh KD, Chetia D, Mazumdar S. Antidiabetic activity of methnolic extract of Allium hookerii leaves. Indo American Journal of Pharm Research. 2013; 3(6): 4098-4104

33) Rudrapal M, Chetia D, Prakash A. Synthesis, antimalarial-, and antibacterial activity evaluation of some new 4-aminoquinoline derivatives. Med Chem Res. 2013; 22: 3703–3711

34) Jha AK, Chetia D. In vitro-in vivo performance evaluation of treated Plantago ovata husk based fast dissolving tablets of glipizide: Flashtab technology. Asian J Pharm. 2014; 8(4): 250-258

35) Deb BC, Kumar A, Chetia D. Pharmacognostical studies on the leaves of Sarcochlamys pulcherrima (Roxb) Goud. Indian Journal of Natural Products and Resources. 2014; 5 (2): 164-170

36) Singh KD, Chetia D, Junejo JA. Antiulcer and in vitro antioxidant activity of Allium hookerii: an ethnomedicinal plant of Manipur. Asian J Pharm Clin Res, 2015; 8(5): 130-135

37) Kumawat MK, Chetia D. Molecular docking studies of some novel 1,2,4,5-tetraoxane derivatives as antimalarial agents. World Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(10): 890-908

38) Kumawat MK, Chetia D. Synthesis, antimalarial activity evaluation and molecular docking studies of some novel dispiro-1,2,4,5-tetraoxanes. Bangladesh J Pharmacol. 2015; 10(4): 917-923

39) Sharma D, Chetia D, Rudrapal M. Design, Synthesis and Antimalarial Activity of Some New 2-Hydroxy-1,4-naphthoquinone-4-hydroxyaniline Hybrid Mannich Bases. Asian J. Chem. 2016; 28 (4): 782-788

40) Kumawat MK, Chetia D, Parida P. Synthesis, antimalarial activity evaluation and docking studies of some novel tetraoxaquines. Med Chem Res. 2016; 25: 1993-2004

41) Kumawat MK, Chetia D. Molecular docking studies of some novel hybrid tetraoxaquines & dispirotetraoxanes as antimalarial agents. Int J Pharm Sci Res. 2016; 7(3): 1348-1359

42) Sarma M, Chetia D, Singh KD, Banu ZW, Dohutia C. Synthesis and evaluation of hybrid Mannich base-tetraoxane derivatives as potent anti-malarial agents. Int J Pharm Anal Res. 2016; 5(2): 287-293

43) Rudrapal M, Chetia D. QSAR Analysis of 7-Chloro-4-Aminoquinoline Derivatives as Antimalarial Agents. Asian J Org Med Chem. 2016; 1(2): 51-54

44) Kumawat MK, Singh UP, Singh B, Prakash A, Chetia D. Synthesis and Antimalarial Activity Evaluation of 3-(3-(7-chloroquinolin-4-ylamino) propyl)-1,3-thiazinan-4-one Derivatives. Arabian Journal of Chemistry. 2016; 9: S643-S647

45) Gogoi J, Chetia D, Kumawat MK, Rudrapal M. Synthesis and Antimalarial Activity Evaluation of Some Mannich Bases of Tetraoxane-Phenol Conjugate. Indian Journal of Pharmaceutical Education and Research. 2016; 50(4): 591-597

46) Rudrapal M, Chetia D. Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.  Drug Design, Development and Therapy. 2016; 10: 3575–3590

47) Dohutia C, Chetia D, Singh KD. Curcumin Against Malaria: From Traditional Medicine to Development of Synthetic Analogs- A Bioorganic Approach. Current Traditional Medicine. 2016; 2(2): 124-133

48) Sharma R, Goswami A, Rudrapal M, Sharma D, Sharma HK, Chetia D. In vitro evaluation of the antimalarial activity of a designed novel quinuclidine derivative. Current Science. 2016; 111(12): 2028-2030

49) Kashyap A, Chetia D, Rudrapal M. Synthesis, Antimalarial Activity Evaluation and Drug-likeness Study of Some New Quinoline-Lawsone Hybrids. Indian J Pharm Science. 2016; 78(6): 892-911

50) Dohutia C, Chetia D, Upadhyaya S. Ethno-medicinal Survey on Tai-Ahom Community of Assam. Ethno Med. 2016; 10(4): 461-471

51) Rudrapal M, Chetia D. QSAR study of trioxane derivatives as antimalarial agents. Curr Trend Pharm Res. 2016; 3(1): 1-17

52)  Gogoi G, Borua PK, Chetia D. GA3 Assisted Seed Dormancy Breaking in Abelmoschus mochatus Medic. Subsp. Mochatus. Cercetari Agronomice in Moldova. 2016; 49(4): 27-34

53) Zaman K, Chetia D, Ali M. Isolation of Two New Cheilanthane-Type Tricarboxylic Sesterterpenoids from Leaves of Caesalpinia crista Linn.: A Traditionally Used Plant of Assam, India. Asian J. Chem. 2017; 29 (3): 485-488

54) Kaishap PP, Duarah G, Chetia D, Gogoi S. Ru (II)-Catalyzed annulation of benzamidines and alkynes by C–H/ N–H activation: a facile synthesis of 1-amino isoquinolines. Org. Biol. Chem. 2017; 15: 3491-3498

55) Dohutia C, Chetia D, Gogoi K, Sarma K. Design, in silico and in vitro evaluation of curcumin analogues against Plasmodium falciparum. Experimental Parasitology. 2017; 175: 51–58

56) Rudrapal M, Chetia D, Singh V. Novel series of 1,2,4-trioxane derivatives as antimalarial agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2017; 32 (1): 1159–1173

57) Dohutia C, Chetia D, Gogoi K, Bhattacharyya DR, Sarma K. Molecular docking, synthesis and in vitro antimalarial evaluation of certain novel curcumin analogues. Braz. J. Pharm. Sci. 2017; 53(4): 1-14

58) Rudrapal M, Chetia D. Plant flavonoids as potential source of future antimalarial leads. Systematic Reviews in Pharmacy. 2017; 8 (1): 13-18

59) Kaishap PP, Duarah G, Sarma B, Chetia D, Gogoi S. Ruthenium (II)-Catalyzed Synthesis of Spirobenzofuranones by a Decarbonylative Annulation Reaction. Angew. Chem. Int. Ed. 2018; 57(2): 456 –460

60) Rudrapal M, Banu ZW, Chetia D. Newer series of trioxane derivatives as potent antimalarial agents. Med Chem Res. 2018; 27: 653–668

61) Medhi A, Chetia D, Rudrapal M. Synthesis and Antimalarial Activity of Lawsone Mannich Base Derivatives. Indian Journal of Pharmaceutical Education and Research. 2018; 52(3): 472-479

62) Bhuyan B, Chetia D. An ethnomedicinal study focusing the genus Costus in Assam with emphasis on traditional medicine. Journal of Medicinal Plants. 2018; 6(2): 178-188

63) Gogoi K, Chetia D, Barua NC, Gogoi N, Dohutia C. In vitro Antimalarial Evaluation and Molecular Docking Analysis of Mannich Base Curcumin Analogues against the Artemisinin Target PfATP6. Asian Journal of Pharmacy and Pharmacology. 2019; 5 (1): 120-128

64) Patowary P, Chetia D, Kalita J, Rudrapal M. Design, Synthesis and Antimalarial Activity of Flavonoid Derivatives. Indian J Heterocycl Chem.  2019; 29 (1): 53-58

65) Rudrapal M, Chetia D. Development of Trioxances as Novel Antimalarial agents.  Curr Trends Pharm Res. 2019; 6(2): 120-127

66) Kalita J, Chetia D, Rudrapal M. Molecular Docking, Drug-likeness Studies and ADMET Prediction of Quinoline Imines for Antimalarial Activity. J Med Chem Drug Des. 2019; 8(2): 208-218

67) Gogoi N, Chetia D. Preliminary validation of ethnomedicinal plants used in the preparation of antimalarial herbal remedies by in vitro screening method. Curr Trend Pharm Res. 2019; 6(1): 63-75

68) Kumawat MK, Singh UP, Chetia D. Design and discovery of 3,6-substituted 1,2,4,5-tetraoxanes as new class of falcipain-2 inhibitors for antimalarial action. Pharmaceutical Chemistry Journal.  2019; 53 (9): 822-830

69) Bhuyan B, Chetia D. In vivo Validation of Folkloric Use of Costus pictus D. Don as Antidiabetic Plant in Assam, using Streptozotocin Induced Wister Rat Model. Ind J Clin Biochem. 2019; 35(2): 225-231

70) Rudrapal M, Chetia D. Virtual Screening, Molecular Docking and QSAR Studies in Drug Discovery and Development Programme. Journal of Drug Delivery and Therapeutics. 2020; 10(4): 225-233

71) Kalita J, Chetia D, Rudrapal M. Design, Synthesis, Antimalarial Activity and Docking Study of 7-Chloro-4-(2-(substituted benzylidene) hydrazineyl) quinolines. Medicinal Chemistry. 2020; 16 (7): 928-937

72) Gogoi B, Gogoi N, Chowdhury P, Chetia D. Repurposing of FDA approved antibiotics as antimalarial agents: A network pharmacology based in silico approach.  International Journal of Infectious Diseases. 2020; 101(S1): 116-117

73) Garg A, Borah D, Trivedi P, Gogoi D, Chaliha AK, Ali AA, Chetia D, Chaturvedi V, Sarma D. A Simple Work-Up-free, Solvent-free Approach to Novel Amino Acid Linked 1, 4-Disubstituted 1, 2, 3-Triazoles as Potent Antituberculosis Agents. ACS omega. 2020; 5(46): 29830-29837

74) Mahanta S,  Chowdhury P,  Gogoi N, Goswami N,  Borah D, Kumar R,  Chetia D, Borah P, Buragohain AK,  Gogoi B. Potential anti-viral activity of approved repurposed drug against main protease of SARS-CoV-2: an in silico based approach. Journal of Biomolecular Structure and Dynamics. 2021; 39 (10): 3802-3811

75) Gogoi B, Chowdhury P, Goswami N, Gogoi N, Naiya T, Chetia P, Mahanta S, Chetia D, Tanti B, Borah P, Handique PJ. Identification of potential plant-based inhibitor against viral proteases of SARS-CoV-2 through molecular docking, MM-PBSA binding energy calculations and molecular dynamics simulation. Molecular diversity. 2021; 25(3): 1963-1977

76) Gogoi N, Chetia, D, Gogoi B, Das A. Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In-Silico and Whole Cell-based In vitro Approach. Current Computer-Aided Drug Design. 2021; 17 (1): 69-82

77) Gogoi N, Gogoi B, Chetia D. In vitro antimalarial activity evaluation of two ethnomedicinal plants against chloroquine sensitive and resistant strains of Plasmodium falciparum. Clinical Phytoscience. 2021; 7(1): 1-10

78) Othman IMM, Mahross MH, Gad-Elkareem MAM, Rudrapal M, Gogoi N, Chetia D, Aouadi K, Snoussi M, Kadri A. Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel aryl hydrazothiazolyl sulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations. Journal of Molecular Structure. 2021; 1243(2): 130862

79) Patowary L, Kashyap P, Chetia D, Gogoi N. Docking based virtual screening of some new 4-Aminoquinolines against PfCRT. Curr Trends Pharm Res. 2021; 8(1): 212-226

80) Gogoi N, Chowdhury P, Goswami AK, Das A, Chetia D, Gogoi B. Computational guided identification of a citrus flavonoid as potential inhibitor of SARS-CoV-2 main protease. Molecular Diversity. 2021; 25(3): 1745-1759

81) Ghosh S, Chetia D, Gogoi N, Rudrapal M. Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors. BioTechnologia. 2021; 102(3): 257-275

82) Gogoi N, Chetia D, Gogoi B, Das A. Multiple-targets Directed Screening of Flavonoid Compounds from Citrus Species to find out Antimalarial Lead with Predicted Mode of Action: An In-Silico and Whole Cell-based In vitro Approach. Curr Comput Aided Drug Des. 2021; 17(1): 69-82

83) Kumawat MK, Chetia D. Synthesis, Antimalarial Activity Evaluation and Molecular Docking Studies of some new substituted Spiro-1,2,4,5-tetraoxane Derivatives. Pharm Chem J. 2021; 55(8): 814-820

84) Singh B, Chetia D, Kumawat MK. Synthesis and In Vitro Antimalarial Activity Evaluation of Some New 1, 2-Diaminopropane Side-Chain-Modified 4-Aminoquinoline Mannich Bases. Pharm Chem J. 2021; 55 (7): 724-731

85) Zothantluanga JH, Gogoi N, Shakya A, Chetia D, Lalthanzara H. Computational guided identification of potential leads from Acacia pennata (L.) Willd. as inhibitors for cellular entry and viral replication of SARS-CoV-2.  Futur J Pharm Sci. 2021; 7(201): 1-18

86) Rudrapal M, Gogoi N, Chetia D, Khan J, Banwas S, B Alshehri, Alaidarous MA, Laddha UD, Khainar SJ, Walode SG. Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness/ADMET studies. Saudi J Biol Sci. 2022; 29 (4): 2432-2446 

87) Rudrapal M, Celik I, Khan J, Ansari MA, Alomary MN, Yadav R, Sharma T, Trina Tallei TE, Pasala PK, Sahoo RK, Khairnar SJ, Bendale AR, Zothantluanga JH, Chetia D, Walode SG. Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through computational investigations. Journal of King Saud University – Science. 2022; 34 (2022) 101826

88) Ezugwu JA, Okoro UC, Ezeokonkwo MA, Hariprasad KS, Rudrapal M, Ugwu DI, Gogoi N, Chetia D, Celik I, Ekoh OC. Design, Synthesis, Molecular Docking, Molecular Dynamics and in-vivo Antimalarial Activity of New Dipeptide-Sulfonamides, ChemistrySelect, 2022; doi.org/10.1002/slct.202103908

89) Zothantluanga JH, Abdalla M, Rudrapal M, Tian Q, Chetia D & Li J. Computational Investigations for Identification of Bioactive Molecules from Baccaurea ramiflora and Bergenia ciliata as Inhibitors of SARS-CoV-2 Mpro. Polycyclic Aromatic Compounds, 2022; DOI: 10.1080/10406638.2022.2046613

90) Umar AK, Zothantluanga JH, Aswin K, Moulana S, Zubair MS, Lalhlenmawia, Rudrapal M, Chetia D. Antiviral phytocompounds “ellagic acid” and “(+)-sesamin” of Bridelia retusa identified as potential inhibitors of SARS-CoV-2 3CL pro using extensive molecular docking, molecular dynamics simulation studies, binding free energy calculations, and bioactivity prediction. Struct Chem, 2022; doi.org/10.1007/s11224-022-01959-3

91) Patowary L, Borthakur MS, Zothantluanga JH, Chetia D. Repurposing of FDA approved drugs having structural similarity to artemisinin against PfDHFR-TS through molecular docking and molecular dynamics simulation studies. Curr Trends Pharm Res, 2022; 8 (2): 14-34.

92) Gogoi NChowdhury PGoswami AKDas AChetia DGogoi B.  Integrated computational approach towards repurposing of antimalarial drug against SARS-CoV-2 main protease. Struct Chem, 2022; doi: 10.1007/s11224-022-01916-0.

Books and Book Chapters:

Books Published/Edited:

 1. Dolui AK (Ed), Das S, Chetia D. (Associate Editors). Management of Natural Resources for Better Health Care (Proceedings of National Seminar, Dept. of Pharm. Sciences, Dibrugarh University). Registrar, Dibrugarh University. 2002; ISBN: 81-88424-00-5

 2. Zothantluanga JH, Lalthanzara H, Shakya A, Chetia D. The outbreak of COVID-19 in Mizoram, India. Rizug, Guwahati. 2020; ISBN: 978-81-941388-6-0

Book Chapters:

1) Rudrapal M, Chetia D, Sarwa KK, Bhattacharya S. Nanotoxicity: Physicochemical and Biological (PK-PD) Perspectives. In: Rauta PR, Mohanta YK, Nayak D. (Eds). Nanotechnology in Biology and Medicine: Research Advancements & Future Perspectives. CRC Press; 2019: ISBN: 9780429259333

2)  Rudrapal M, Chetia D.  Herbal Drugs: Efficacy, Toxicity, and Safety Issues. In: Mandal SC, Chakraborty R, Sen S. (Eds.) Evidence-Based Validation of Traditional Medicines-A Comprehensive Approach. Springer Nature Singapore Pte Ltd.; 2021: ISBN 978-981-15-8126-7, ISBN 978-981-15-      8127-4 (eBook)

3)  Rudrapal M, Chetia D.  Malaria and Recent Developments in Antimalarial Drugs. In: Egbuna C, Akram M, Ifemeje JC. (Eds.) Neglected Tropical Diseases and Phytochemicals in Drug Discovery. John Wiley & Sons, Inc.; 2022: Print ISBN:9781119616603; Online ISBN: 9781119617143

4)  Bhuyan B, Chetia D and Prakash Rajak P. Traditional Usage of Plants of Costus Species in Assam, India. In: El-Shemy HA (Ed). Natural Medicinal Plants. DOI10.5772/intechopen.91542; 2022: ISBN: 978-1-83969-276-5; PRINT ISBN: 978-1-83969-275-8

 

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